{
  "id": 18553,
  "label": "squamous cell carcinoma of liver and intrahepatic biliary tract",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0018534",
  "properties": {
    "xrefs": [
      "GARD:0021789",
      "MEDGEN:1668494",
      "Orphanet:424975",
      "UMLS:C4749400"
    ],
    "synonyms": [
      "squamous cell carcinoma of liver and IBT"
    ],
    "categories": [
      {
        "ref": "MONDO:0004335",
        "name": "digestive system disorder"
      },
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "Squamous cell carcinoma of liver and intrahepatic biliary tract is an extremely rare, primary, malignant liver and biliray tract epithelial tumor originating in the intrahepatic bile duct epithelium histologically characterized by the presence of keratinization and/or intracellular bridges. Patients typically present abdominal pain in the right upper quadrant, jaundice, nausea, vomiting, anorexia, weight loss, fever and/or dyspepsia."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 2,
  "parents": [
    {
      "id": 6823,
      "label": "squamous cell carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4600,
        6734
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1749",
          "EFO:0000707",
          "ICDO:8070/3",
          "MEDGEN:2874",
          "MESH:D002294",
          "NCIT:C2929",
          "SCTID:402815007",
          "UMLS:C0007137"
        ],
        "synonyms": [
          "carcinoma, squamous cell, malignant",
          "epidermoid carcinoma",
          "epidermoid cell cancer",
          "malignant epidermoid cell neoplasm",
          "malignant epidermoid cell tumor",
          "malignant epidermoid cell tumour",
          "malignant squamous cell neoplasm",
          "malignant squamous cell tumor",
          "malignant squamous cell tumour",
          "squamous carcinoma",
          "squamous cell cancer",
          "squamous cell carcinoma",
          "squamous cell carcinoma (morphologic abnormality)",
          "squamous cell carcinoma NOS (morphologic abnormality)",
          "squamous cell epithelioma"
        ],
        "definition": "A carcinoma arising from squamous epithelial cells. Morphologically, it is characterized by the proliferation of atypical, often pleomorphic squamous cells. Squamous cell carcinomas are graded by the degree of cellular differentiation as well, moderately, or poorly differentiated. Well differentiated carcinomas are usually associated with keratin production and the presence of intercellular bridges between adjacent cells. Representative examples are lung squamous cell carcinoma, skin squamous cell carcinoma, and cervical squamous cell carcinoma."
      },
      "child_count": 78,
      "reference_id": "MONDO:0005096"
    },
    {
      "id": 18551,
      "label": "carcinoma of liver and intrahepatic biliary tract",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4735,
        7738
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0021786",
          "MEDGEN:78921",
          "NCIT:C7927",
          "ONCOTREE:HCCIHCH",
          "Orphanet:424936",
          "UMLS:C0279000"
        ],
        "synonyms": [
          "cancer of liver",
          "cancer of liver and intrahepatic biliary tract",
          "cancer of the liver",
          "cancer of the liver and intrahepatic biliary tract",
          "carcinoma of liver",
          "hepatic cancer",
          "liver and intrahepatic bile duct cancer",
          "liver cancer",
          "liver carcinoma",
          "liver/hepatobiliary cancer",
          "carcinoma of liver and IBT",
          "liver and intrahepatic bile duct carcinoma",
          "liver and intrahepatic biliary tract cancer",
          "liver and intrahepatic biliary tract carcinoma",
          "primary liver carcinoma",
          "hepatocellular carcinoma plus intrahepatic cholangiocarcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A carcinoma that arises from the hepatocytes or intrahepatic bile ducts. The main subtypes are hepatocellular carcinoma (hepatoma) and cholangiocarcinoma."
      },
      "child_count": 14,
      "reference_id": "MONDO:0018531"
    }
  ],
  "children": [
    {
      "id": 5414,
      "label": "squamous cell bile duct carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7152,
        18553
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5537",
          "GARD:0023530",
          "MEDGEN:209017",
          "UMLS:C0861861"
        ],
        "synonyms": [
          "bile duct squamous cell carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A squamous cell carcinoma that involves the bile duct."
      },
      "child_count": 4,
      "reference_id": "MONDO:0003500"
    },
    {
      "id": 23670,
      "label": "liver adenosquamous carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7652,
        18553
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0025991",
          "MEDGEN:858180",
          "NCIT:C118630",
          "UMLS:C3898586"
        ],
        "synonyms": [
          "liver adenosquamous cancer",
          "liver adenosquamous carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A rare carcinoma that arises from the intrahepatic bile ducts and is composed of malignant glandular cells and malignant squamous cells."
      },
      "child_count": 2,
      "reference_id": "MONDO:0056815"
    }
  ],
  "roots": [
    {
      "id": 6823,
      "label": "squamous cell carcinoma"
    },
    {
      "id": 18551,
      "label": "carcinoma of liver and intrahepatic biliary tract"
    }
  ]
}