{
  "id": 18555,
  "label": "adenocarcinoma of gallbladder and extrahepatic biliary tract",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0018536",
  "properties": {
    "xrefs": [
      "GARD:0021791",
      "MEDGEN:1633887",
      "Orphanet:424991",
      "SCTID:765741003",
      "UMLS:C4707555"
    ],
    "synonyms": [
      "adenocarcinoma of gallbladder and EBT",
      "adenocarcinoma of the gallbladder and EBT",
      "adenocarcinoma of the gallbladder and extrahepatic biliary tract"
    ],
    "categories": [
      {
        "ref": "MONDO:0004335",
        "name": "digestive system disorder"
      },
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "Adenocarcinoma of the gallbladder and extrahepatic biliary tract is a rare epithelial carcinoma, arising either in the gallbladder itself or from the epithelium lining the extrahepatic biliary tree, cystic duct and/or peribiliary gland, characterized by nonspecific symptoms, such as abdominal pain, jaundice and vomiting and sometimes mimicking benign biliary diseases. Chronic biliary epithelial inflammation (e.g. primary sclerosing cholangitis, cholelithiasis, choledocholithiasis, liver fluke infestation) is a major risk factor."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 2,
  "parents": [
    {
      "id": 4714,
      "label": "extrahepatic bile duct adenocarcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5076,
        5152
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3495",
          "GARD:0023205",
          "MEDGEN:124642",
          "NCIT:C7975",
          "UMLS:C0279659"
        ],
        "synonyms": [
          "adenocarcinoma of extrahepatic bile duct",
          "adenocarcinoma of the extrahepatic bile duct",
          "extrahepatic bile duct adenocarcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A carcinoma that arises from glandular epithelial cells of the extrahepatic bile duct"
      },
      "child_count": 14,
      "reference_id": "MONDO:0002665"
    },
    {
      "id": 18842,
      "label": "carcinoma of gallbladder and extrahepatic biliary tract",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        20541
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0018850",
          "MEDGEN:1797980",
          "MedDRA:10007426",
          "Orphanet:56044",
          "UMLS:C5566557"
        ],
        "synonyms": [
          "carcinoma of gallbladder and EBT"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "Carcinoma of the gallbladder (GBC) is the most common and aggressive form of biliary tract cancer (BTC) usually arising in the fundus of the gallbladder, rapidly metastasizing to lymph nodes and distant sites."
      },
      "child_count": 2,
      "reference_id": "MONDO:0018918"
    }
  ],
  "children": [
    {
      "id": 18978,
      "label": "cholangiocarcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        18555
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4947",
          "EFO:0005221",
          "GARD:0009304",
          "ICDO:8160/3",
          "MEDGEN:60210",
          "MESH:D018281",
          "MedDRA:10004593",
          "MedDRA:10008593",
          "NCIT:C4436",
          "NORD:926",
          "ONCOTREE:CHOL",
          "Orphanet:70567",
          "SCTID:312104005",
          "UMLS:C0206698",
          "icd11.foundation:2110597275"
        ],
        "synonyms": [
          "bile duct cancer",
          "intrahepatic bile duct cancer (cholangiocarcinoma)",
          "CC",
          "CCA",
          "Cholangiocar.- intra/extrahepatic",
          "Cholangiocellular carcinoma",
          "cholangiocarcinoma",
          "cholangiocarcinoma, intrahepatic and extrahepatic bile ducts (adenocarcinoma)",
          "cholangiocarcinoma, malignant"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A carcinoma that arises from the intrahepatic biliary tree (intrahepatic cholangiocarcinoma) or from the junction, or adjacent to the junction, of the right and left hepatic ducts (hilar cholangiocarcinoma). Grossly, the malignant lesions are solid, nodular, and grayish. Morphologically, the vast majority of cases are adenocarcinomas. Signs and symptoms include malaise, weight loss, right upper quadrant abdominal pain, and night sweats. Early detection is difficult and the prognosis is generally poor."
      },
      "child_count": 1,
      "reference_id": "MONDO:0019087"
    },
    {
      "id": 23444,
      "label": "combined hepatocellular carcinoma and cholangiocarcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        18555
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0022200",
          "MEDGEN:113160",
          "NCIT:C3828",
          "Orphanet:529852",
          "SCTID:274902006",
          "UMLS:C0221287",
          "icd11.foundation:1097637010",
          "icd11.foundation:1600108866",
          "icd11.foundation:894488488"
        ],
        "synonyms": [
          "carcinoma of liver and intrahepatic biliary tract",
          "liver and intrahepatic biliary tract carcinoma",
          "Cholangiohepatoma",
          "Hepatocholangiocarcinoma",
          "Mixed hepatocellular cholangiocarcinoma",
          "carcinoma of the liver and intrahepatic biliary tract",
          "combined hepatocellular cancer and cholangiocarcinoma (bile duct cancer)",
          "combined hepatocellular cancer and intrahepatic bile duct cancer (cholangiocarcinoma)",
          "combined hepatocellular carcinoma and cholangiocarcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A rare tumor containing unequivocal elements of both hepatocellular and cholangiocarcinoma that are intimately admixed. This tumor should be distinguished from separate hepatocellular carcinoma and cholangiocarcinoma arising in the same liver. The prognosis of this tumor is poor."
      },
      "child_count": 0,
      "reference_id": "MONDO:0044791"
    }
  ],
  "roots": [
    {
      "id": 4714,
      "label": "extrahepatic bile duct adenocarcinoma"
    },
    {
      "id": 18842,
      "label": "carcinoma of gallbladder and extrahepatic biliary tract"
    }
  ]
}