{
  "id": 18556,
  "label": "squamous cell carcinoma of gallbladder and extrahepatic biliary tract",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0018537",
  "properties": {
    "xrefs": [
      "GARD:0021792",
      "MEDGEN:1635098",
      "Orphanet:424996",
      "SCTID:766978002",
      "UMLS:C4707898"
    ],
    "synonyms": [
      "squamous cell carcinoma of gallblader and EBT"
    ],
    "categories": [
      {
        "ref": "MONDO:0004335",
        "name": "digestive system disorder"
      },
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "Squamous cell carcinoma of the gallbladder and extrahepatic biliary tract is a rare hepatic and biliary tract tumor, arising either in the gallbladder itself or in the epithelium lining the extrahepatic biliary tree, the cystic duct and peribiliary glands. It is characterized by a substantial keratinization with abundant keratohyalin pearls and central deposition of dense keratin material within infiltrative nests and locally aggressive nature. In the early stages of the disease symptoms are vague and nonspecific (abdominal pain, jaundice and vomiting). In the advanced stages it may present with a bulky tumor and symptoms of adjacent organ involvement."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 7758,
      "label": "extrahepatic bile duct squamous cell carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5076,
        5414
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:1000248",
          "GARD:0024328",
          "NCIT:C5777"
        ],
        "synonyms": [
          "bile duct squamous cell carcinoma",
          "squamous cell bile duct carcinoma",
          "squamous cell carcinoma of bile duct",
          "squamous cell carcinoma of the bile duct",
          "extrahepatic bile duct squamous cell carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A carcinoma that arises from the extrahepatic bile ducts. It is composed entirely by malignant squamous epithelial cells."
      },
      "child_count": 6,
      "reference_id": "MONDO:0006203"
    },
    {
      "id": 18842,
      "label": "carcinoma of gallbladder and extrahepatic biliary tract",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        20541
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0018850",
          "MEDGEN:1797980",
          "MedDRA:10007426",
          "Orphanet:56044",
          "UMLS:C5566557"
        ],
        "synonyms": [
          "carcinoma of gallbladder and EBT"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "Carcinoma of the gallbladder (GBC) is the most common and aggressive form of biliary tract cancer (BTC) usually arising in the fundus of the gallbladder, rapidly metastasizing to lymph nodes and distant sites."
      },
      "child_count": 2,
      "reference_id": "MONDO:0018918"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 7758,
      "label": "extrahepatic bile duct squamous cell carcinoma"
    },
    {
      "id": 18842,
      "label": "carcinoma of gallbladder and extrahepatic biliary tract"
    }
  ]
}