{
  "id": 18571,
  "label": "fetal lower urinary tract obstruction",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0018559",
  "properties": {
    "xrefs": [
      "GARD:0021804",
      "MEDGEN:931214",
      "Orphanet:435365",
      "SCTID:717752005",
      "UMLS:C4305545",
      "icd11.foundation:1661120971"
    ],
    "synonyms": [
      "LUTO"
    ],
    "categories": [
      {
        "ref": "MONDO:0002118",
        "name": "urinary system disorder"
      }
    ]
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 5,
  "parents": [
    {
      "id": 6948,
      "label": "kidney disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4253
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:557",
          "EFO:0003086",
          "ICD9:583.81",
          "MEDGEN:9635",
          "MESH:D007674",
          "NCIT:C3149",
          "SCTID:90708001",
          "UMLS:C0022658"
        ],
        "synonyms": [
          "disease of kidney",
          "disease or disorder of kidney",
          "disorder of kidney",
          "kidney disease",
          "kidney disease or disorder",
          "kidney disorder",
          "renal disease",
          "renal disorder",
          "nephropathy"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          }
        ],
        "definition": "A disease involving the kidney."
      },
      "child_count": 57,
      "reference_id": "MONDO:0005240"
    },
    {
      "id": 19192,
      "label": "urogenital tract malformation",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        19507
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0019029",
          "ICD10CM:Q60-Q64",
          "MEDGEN:52948",
          "Orphanet:83001",
          "UMLS:C0042063"
        ]
      },
      "child_count": 3,
      "reference_id": "MONDO:0019356"
    }
  ],
  "children": [
    {
      "id": 8451,
      "label": "prune belly syndrome",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4370,
        18571,
        23932
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0060889",
          "GARD:0007479",
          "ICD10CM:Q79.4",
          "ICD9:756.71",
          "MEDGEN:18718",
          "MESH:D011535",
          "MedDRA:10051025",
          "NANDO:2200185",
          "NCIT:C85033",
          "NORD:1623",
          "OMIM:100100",
          "Orphanet:2970",
          "SCTID:5187006",
          "UMLS:C0033770",
          "icd11.foundation:1393408621"
        ],
        "synonyms": [
          "Obrinsky syndrome",
          "Obrisnksy syndrome",
          "abdominal muscle deficiency syndrome",
          "eagle-Barret syndrome",
          "prune belly syndrome",
          "syndrome of agenesis of abdominal muscles",
          "triad syndrome",
          "PBS",
          "abdominal muscles, absence of, with urinary tract Abnormality and cryptorchidism",
          "eagle-Barrett syndrome"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          },
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          }
        ],
        "definition": "Prune belly syndrome is a rare congenital disorder, belonging to the group of fetal lower urinary tract obstructions (LUTO), involving variable dilation of the lower urinary tract in association with partial or complete absence of the lateral and inferior abdominal wall musculature and in males bilateral non-palpable undescended testes."
      },
      "child_count": 0,
      "reference_id": "MONDO:0007032"
    },
    {
      "id": 16107,
      "label": "atresia of urethra",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        18571
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0018678",
          "HP:0000068",
          "ICD10CM:Q64.3",
          "MEDGEN:576882",
          "MedDRA:10064895",
          "Orphanet:105",
          "SCTID:253902002",
          "UMLS:C0345345"
        ],
        "synonyms": [
          "atresia of urethra",
          "atresia of urethra (disease)",
          "urethral atresia"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          }
        ],
        "definition": "Atresia of the urethra is a rare congenital bladder outlet obstruction, a fetal lower urinary tract obstruction (fetal LUTO), that is usually fatal. Unless there is some other egress for the urine to escape the bladder, such as patent urachus or anuro-rectal communication, these lesions are not compatible with renal development."
      },
      "child_count": 0,
      "reference_id": "MONDO:0015195"
    },
    {
      "id": 19430,
      "label": "posterior urethral valve",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        18571
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0007439",
          "ICD10CM:Q64.2",
          "ICD9:753.8",
          "MEDGEN:451008",
          "MedDRA:10036369",
          "NCIT:C99021",
          "NORD:242851",
          "Orphanet:93110",
          "SCTID:253900005",
          "UMLS:C0238506"
        ],
        "synonyms": [
          "PUV",
          "Posterior Urethral Valves",
          "congenital posterior urethral valves",
          "Posterior urethral valves"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          }
        ],
        "definition": "Posterior urethral valve (PUV) is the most common anomaly of fetal lower urinary tract obstruction (LUTO) and is characterized by an abnormal congenital obstructing membrane that is located within the posterior urethra associated with significant obstruction of the male bladder restricting normal bladder emptying."
      },
      "child_count": 0,
      "reference_id": "MONDO:0019640"
    },
    {
      "id": 23163,
      "label": "urethral obstruction sequence",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        3761,
        18571
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0005428",
          "MEDGEN:75568",
          "MESH:C536477",
          "SCTID:18241005",
          "UMLS:C0265363"
        ],
        "synonyms": [
          "early urethral obstruction sequence",
          "EUOS",
          "renal dysplasia or hydronephrosis, oligohydramnios and subsequent lung hypoplasia due to urethral obstruction"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0043207"
    },
    {
      "id": 24773,
      "label": "anterior urethral valve",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        18571
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0028046",
          "MEDGEN:609136",
          "Orphanet:435372",
          "UMLS:C0431755"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          }
        ],
        "definition": "A rare, congenital, fetal lower urinary tract obstruction (LUTO) anomaly occurring in males and characterized by a posteriorly directed semilunar fold arising from the floor of the anterior urethra and causing urethral obstruction during micturition. The valves may be located anywhere distal to the membranous urethra. Clinical presentation is highly variable, depending on age and degree of urinary obstruction, and includes urinary incontinence, urinary retention, weak urinary stream, post-micturitional dribbling, bulging on the ventral penis, urinary tract infection, and urosepsis."
      },
      "child_count": 0,
      "reference_id": "MONDO:0700447"
    }
  ],
  "roots": [
    {
      "id": 6948,
      "label": "kidney disorder"
    },
    {
      "id": 19192,
      "label": "urogenital tract malformation"
    }
  ]
}