{
  "id": 18610,
  "label": "pure autonomic failure",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0018608",
  "properties": {
    "xrefs": [
      "GARD:0010428",
      "MEDGEN:98293",
      "MESH:D054970",
      "NORD:1948",
      "Orphanet:441",
      "SCTID:84438001",
      "UMLS:C0393911",
      "icd11.foundation:734022291"
    ],
    "synonyms": [
      "Bradbury Eggleston syndrome",
      "Bradbury-Eggleston syndrome",
      "PAF",
      "Pure dysautonomia",
      "Pure idiopatic dysautonomia",
      "idiopathic orthostatic hypotension",
      "idiopathic orthostatic hypotension (a symptom)",
      "orthostatic hypotension (a symptom)"
    ],
    "categories": [
      {
        "ref": "MONDO:0005071",
        "name": "nervous system disorder"
      }
    ],
    "definition": "Pure autonomic failure (PAF) is a neurodegenerative disease that affects the sympathetic branch of the autonomous nervous system and that manifests with orthostatic hypotension."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 3525,
      "label": "autonomic nervous system disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4657,
        5512
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:11465",
          "EFO:0009532",
          "ICD9:337.1",
          "ICD9:337.9",
          "MEDGEN:218837",
          "MESH:D001342",
          "SCTID:128123007",
          "SCTID:15241006",
          "UMLS:C1145628",
          "icd11.foundation:1397803237"
        ],
        "synonyms": [
          "autonomic nervous disease",
          "autonomic nervous system disease",
          "autonomic nervous system disease or disorder",
          "disease of autonomic nervous system",
          "disease or disorder of autonomic nervous system",
          "disorder of autonomic nervous system",
          "disorder of peripheral autonomic nervous system",
          "disorder of the autonomic nervous system",
          "autonomic peripheral nervous system diseases",
          "dysautonomia",
          "peripheral autonomic nervous system diseases",
          "ANS (autonomic nervous system) diseases",
          "ANS disease",
          "ANS diseases",
          "autonomic central nervous system diseases",
          "autonomic disease",
          "autonomic diseases",
          "autonomic dysfunction, segmental",
          "autonomic dysfunctions, segmental",
          "autonomic nervous system disorders",
          "central autonomic nervous system diseases",
          "disorders of the autonomic nervous system",
          "nervous system diseases, autonomic",
          "nervous system diseases, sympathetic",
          "segmental autonomic dysfunction",
          "segmental autonomic dysfunctions"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A disease involving the autonomic nervous system."
      },
      "child_count": 26,
      "reference_id": "MONDO:0001292"
    },
    {
      "id": 9146,
      "label": "multiple system atrophy",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        2963,
        7073
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4752",
          "EFO:1001050",
          "GARD:0007079",
          "MEDGEN:98276",
          "MESH:D019578",
          "MedDRA:10064060",
          "NANDO:1200034",
          "NCIT:C84909",
          "NORD:1472",
          "Orphanet:102",
          "UMLS:C0393571",
          "icd11.foundation:1890931931"
        ],
        "synonyms": [
          "MSA",
          "Shy-Drager syndrome",
          "multisystem atrophy",
          "Shy-dragger syndrome (formerly)",
          "autonomic failure, Pure",
          "hypotension, orthostatic",
          "susceptibility to multiple system atrophy 1"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Multiple system atrophy (MSA) is a neurodegenerative disorder characterized by autonomic failure (cardiovascular and/or urinary), parkinsonism, cerebellar impairment and corticospinal signs with a median survival of 6-9 years."
      },
      "child_count": 8,
      "reference_id": "MONDO:0007803"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 3525,
      "label": "autonomic nervous system disorder"
    },
    {
      "id": 9146,
      "label": "multiple system atrophy"
    }
  ]
}