{
  "id": 18657,
  "label": "hepatoblastoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0018666",
  "properties": {
    "xrefs": [
      "DOID:687",
      "EFO:1000292",
      "GARD:0002657",
      "ICD10CM:C22.2",
      "ICDO:8970/3",
      "MEDGEN:61644",
      "MESH:D018197",
      "MedDRA:10062001",
      "NANDO:2200046",
      "NCIT:C3728",
      "ONCOTREE:LIHB",
      "Orphanet:449",
      "UMLS:C0206624",
      "icd11.foundation:1241693063",
      "icd11.foundation:1556608523"
    ],
    "synonyms": [
      "HBL",
      "hepatoblastoma",
      "hepatoblastoma, malignant",
      "paediatric embryonal hepatoma",
      "paediatric hepatoblastoma",
      "pediatric embryonal hepatoma",
      "pediatric hepatoblastoma"
    ],
    "categories": [
      {
        "ref": "MONDO:0004335",
        "name": "digestive system disorder"
      },
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "Hepatoblastoma (HB) is a malignant hepatic tumor and is the most common pediatric liver cancer. It is characterized by anorexia, weight loss and an enlarged abdomen. HB is more common in patients with familial adenomatous polyposis (FAP), and can occur in patients with other pre-existing liver conditions. About 5% of HB cases are associated with genetic factors, especially overgrowth syndromes, such as Beckwith-Wiedemann syndrome (BWS) or hemihypertrophy."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 2,
  "parents": [
    {
      "id": 7212,
      "label": "embryonal neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6798
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:688",
          "EFO:0005784",
          "MEDGEN:45034",
          "NCIT:C3264",
          "ONCOTREE:EMBT",
          "UMLS:C0027654"
        ],
        "synonyms": [
          "embryonal neoplasm",
          "embryonal tumor",
          "embryonal tumour",
          "EMBT",
          "embryonal cancer"
        ],
        "definition": "A usually malignant neoplasm composed of primitive (immature) tissues that resemble fetal tissues. Medulloblastoma, Ependymoblastoma, Pineoblastoma, and Wilms tumor are representative embryonal neoplasms. --2003"
      },
      "child_count": 12,
      "reference_id": "MONDO:0005564"
    },
    {
      "id": 8660,
      "label": "hepatocellular carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6712,
        18551
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:684",
          "DOID:686",
          "EFO:0000182",
          "GARD:0016773",
          "ICD10CM:C22.0",
          "ICDO:8170/3",
          "MEDGEN:389187",
          "MESH:D006528",
          "MedDRA:10049010",
          "NANDO:2200047",
          "NCIT:C3099",
          "NORD:1907",
          "OMIM:114550",
          "ONCOTREE:HCC",
          "Orphanet:88673",
          "UMLS:C2239176",
          "icd11.foundation:1294035808"
        ],
        "synonyms": [
          "HCC",
          "cancer, hepatocellular",
          "carcinoma of liver",
          "carcinoma of liver cells",
          "carcinoma of the liver cells",
          "carcinoma, hepatocellular, malignant",
          "hepatoblastoma, somatic",
          "hepatocellular adenocarcinoma",
          "hepatocellular cancer",
          "hepatocellular cancer, somatic",
          "hepatocellular carcinoma",
          "hepatocellular carcinoma, childhood type, somatic",
          "hepatocellular carcinoma, somatic",
          "hepatoma",
          "liver carcinoma",
          "liver cell cancer (hepatocellular carcinoma)",
          "liver cell carcinoma",
          "primary carcinoma of liver cells",
          "primary carcinoma of the liver cells",
          "adult hepatoma",
          "adult primary hepatocellular carcinoma",
          "hepatoblastoma",
          "hepatoblastoma caused by somatic mutation",
          "liver and intrahepatic bile duct carcinoma",
          "liver cancer"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A malignant tumor that arises from hepatocytes. Hepatocellular carcinoma is relatively rare in the United States but very common in all African countries south of the Sahara and in Southeast Asia. Most cases are seen in patients over the age of 50 years, but this tumor can also occur in younger individuals and even in children. Hepatocellular carcinoma is more common in males than females and is associated with hepatitis B, hepatitis C, chronic alcohol abuse and cirrhosis. Serum elevation of alpha-fetoprotein occurs in a large percentage of patients with hepatocellular carcinoma. Grossly, hepatocellular carcinoma may present as a single mass, as multiple nodules, or as diffuse liver involvement. Microscopically, there is a wide range of differentiation from tumor to tumor (well differentiated to poorly differentiated tumors). Hepatocellular carcinomas quickly metastasize to regional lymph nodes and lung. The overall median survival of untreated liver cell carcinoma is about 4 months. The most effective treatment of hepatocellular carcinoma is complete resection of the tumor. Lately, an increasing number of tumors have been treated with liver transplantation."
      },
      "child_count": 16,
      "reference_id": "MONDO:0007256"
    }
  ],
  "children": [
    {
      "id": 5538,
      "label": "mixed hepatoblastoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        18657
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5789",
          "GARD:0023601",
          "ICDO:8970/3",
          "MEDGEN:233194",
          "NCIT:C7097",
          "UMLS:C1334784"
        ],
        "synonyms": [
          "mixed epithelial and mesenchymal hepatoblastoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A hepatoblastoma characterized by the presence of fetal and embryonal epithelial components and a mesenchymal component."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003650"
    },
    {
      "id": 5539,
      "label": "macrotrabecular hepatoblastoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        18657
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5798",
          "GARD:0023602",
          "MEDGEN:233654",
          "NCIT:C7095",
          "UMLS:C1334543"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A pure fetal or fetal and embryonal epithelial hepatoblastoma characterized by the presence of broad trabeculae."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003651"
    }
  ],
  "roots": [
    {
      "id": 7212,
      "label": "embryonal neoplasm"
    },
    {
      "id": 8660,
      "label": "hepatocellular carcinoma"
    }
  ]
}