{
  "id": 18665,
  "label": "IgG4-related submandibular gland disease",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0018674",
  "properties": {
    "xrefs": [
      "GARD:0021884",
      "MEDGEN:1830092",
      "NCIT:C82887",
      "Orphanet:449432",
      "SCTID:448131008",
      "UMLS:C5679995",
      "icd11.foundation:588811750"
    ],
    "synonyms": [
      "IgG4-related sialadenitis",
      "Kuttner tumor",
      "Kuttner tumour",
      "Kuttner's tumor",
      "Kuttner's tumour",
      "Küttner tumor",
      "Küttner tumour",
      "chronic sclerosing sialadenitis"
    ],
    "categories": [
      {
        "ref": "MONDO:0005046",
        "name": "immune system disorder"
      },
      {
        "ref": "MONDO:0024623",
        "name": "otorhinolaryngologic disease"
      }
    ],
    "definition": "A chronic fibrotic inflammatory process affecting the salivary gland. Signs and symptoms include firm and painful swelling of the salivary gland, often associated with the presence of salivary gland stones."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 3003,
      "label": "autoimmune disease of ear, nose and throat",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        8586,
        21538
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0060030"
        ],
        "synonyms": [
          "autoimmune otorhinolaryngologic disease",
          "autoimmune disease of eyes, ear, nose and throat"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0024623",
            "name": "otorhinolaryngologic disease"
          }
        ],
        "definition": "An autoimmune form of otorhinolaryngologic disease."
      },
      "child_count": 14,
      "reference_id": "MONDO:0000587"
    },
    {
      "id": 17611,
      "label": "immunoglobulin G4-related sclerosing disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        8586
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0080356",
          "GARD:0012521",
          "MEDGEN:473761",
          "MedDRA:10071569",
          "NANDO:1200923",
          "NANDO:1200924",
          "NCIT:C95992",
          "Orphanet:284264",
          "Orphanet:596448",
          "UMLS:C3203653",
          "icd11.foundation:99883782"
        ],
        "synonyms": [
          "IgG4-RD",
          "IgG4-related disease",
          "IgG4-related sclerosing disease",
          "IgG4-related systemic disease",
          "immunoglobulin G4-related sclerosing disease",
          "IgG4-associated disease",
          "IgG4-positive multiorgan lymphoproliferative syndrome",
          "IgG4-related autoimmune disease",
          "IgG4-related systemic sclerosing disease",
          "IgG4-syndrome",
          "hyper-IgG4 disease",
          "multifocal fibrosclerosis",
          "multifocal idiopathic fibrosclerosis",
          "systemic IgG4-related plasmacytic syndrome",
          "systemic IgG4-related sclerosing syndrome"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ],
        "definition": "A recently described mass-forming lesion that occurs in the pancreas, submandibular glands, lacrimal glands, lymph nodes, and hepatobiliary tract. It is characterized by the presence of marked tissue sclerosis and infiltration by numerous plasma cells. The plasma cells show immunohistochemical staining for IgG4 and the serum IgG4 levels are often increased."
      },
      "child_count": 14,
      "reference_id": "MONDO:0017287"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 3003,
      "label": "autoimmune disease of ear, nose and throat"
    },
    {
      "id": 17611,
      "label": "immunoglobulin G4-related sclerosing disease"
    }
  ]
}