{
  "id": 18666,
  "label": "IgG4-related ophthalmic disorder",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0018675",
  "properties": {
    "xrefs": [
      "GARD:0021885",
      "MEDGEN:1800432",
      "Orphanet:449563",
      "UMLS:C5569009"
    ],
    "synonyms": [
      "IgG4-related disease of eye",
      "eye IgG4-related disease"
    ],
    "categories": [
      {
        "ref": "MONDO:0002022",
        "name": "disorder of orbital region"
      },
      {
        "ref": "MONDO:0005046",
        "name": "immune system disorder"
      },
      {
        "ref": "MONDO:0024458",
        "name": "disorder of visual system"
      }
    ],
    "definition": "A IgG4-related disease that involves the eye."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 1,
  "parents": [
    {
      "id": 7019,
      "label": "eye disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4171,
        21415
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1242",
          "DOID:5614",
          "EFO:0003966",
          "ICD9:360",
          "ICD9:360.29",
          "ICD9:360.89",
          "ICD9:360.9",
          "ICD9:379.8",
          "ICD9:379.90",
          "MEDGEN:5092",
          "MESH:D005128",
          "NCIT:C26767",
          "SCTID:371405004",
          "UMLS:C0015397"
        ],
        "synonyms": [
          "disease of eye",
          "disease of eyeball of camera-type eye",
          "disease or disorder of eyeball of camera-type eye",
          "disorder of eye",
          "disorder of eyeball of camera-type eye",
          "eye disease",
          "eye disorder",
          "eyeball of camera-type eye disease",
          "eyeball of camera-type eye disease or disorder",
          "globe disease",
          "disease of eyeball",
          "disorder of eye proper",
          "disorder of eyeball",
          "disorder of globe"
        ],
        "categories": [
          {
            "ref": "MONDO:0002022",
            "name": "disorder of orbital region"
          },
          {
            "ref": "MONDO:0024458",
            "name": "disorder of visual system"
          }
        ],
        "definition": "A non-neoplastic or neoplastic disorder that affects the eye. Representative examples include conjunctivitis, glaucoma, cataract, conjunctival squamous cell carcinoma, uveal melanoma, and retinoblastoma."
      },
      "child_count": 240,
      "reference_id": "MONDO:0005328"
    },
    {
      "id": 17611,
      "label": "immunoglobulin G4-related sclerosing disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        8586
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0080356",
          "GARD:0012521",
          "MEDGEN:473761",
          "MedDRA:10071569",
          "NANDO:1200923",
          "NANDO:1200924",
          "NCIT:C95992",
          "Orphanet:284264",
          "Orphanet:596448",
          "UMLS:C3203653",
          "icd11.foundation:99883782"
        ],
        "synonyms": [
          "IgG4-RD",
          "IgG4-related disease",
          "IgG4-related sclerosing disease",
          "IgG4-related systemic disease",
          "immunoglobulin G4-related sclerosing disease",
          "IgG4-associated disease",
          "IgG4-positive multiorgan lymphoproliferative syndrome",
          "IgG4-related autoimmune disease",
          "IgG4-related systemic sclerosing disease",
          "IgG4-syndrome",
          "hyper-IgG4 disease",
          "multifocal fibrosclerosis",
          "multifocal idiopathic fibrosclerosis",
          "systemic IgG4-related plasmacytic syndrome",
          "systemic IgG4-related sclerosing syndrome"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ],
        "definition": "A recently described mass-forming lesion that occurs in the pancreas, submandibular glands, lacrimal glands, lymph nodes, and hepatobiliary tract. It is characterized by the presence of marked tissue sclerosis and infiltration by numerous plasma cells. The plasma cells show immunohistochemical staining for IgG4 and the serum IgG4 levels are often increased."
      },
      "child_count": 14,
      "reference_id": "MONDO:0017287"
    }
  ],
  "children": [
    {
      "id": 19061,
      "label": "IgG4-related dacryoadenitis and sialadenitis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        3003,
        4032,
        18666
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:12900",
          "GARD:0007043",
          "MEDGEN:6399",
          "MESH:D008882",
          "MedDRA:10051457",
          "MedDRA:10052317",
          "NANDO:1200929",
          "NCIT:C34819",
          "Orphanet:79078",
          "SCTID:7826003",
          "UMLS:C0026103",
          "icd11.foundation:796087277"
        ],
        "synonyms": [
          "Mikulicz disease",
          "chronic dacryoadenitis and sialadenitis",
          "Mikulicz disease (former)",
          "Mikulicz syndrome (former)",
          "Mikulicz's disease (former)"
        ],
        "categories": [
          {
            "ref": "MONDO:0002022",
            "name": "disorder of orbital region"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0024458",
            "name": "disorder of visual system"
          },
          {
            "ref": "MONDO:0024623",
            "name": "otorhinolaryngologic disease"
          }
        ],
        "definition": "IgG4-related dacryoadenitis and sialoadenitis (Mikulicz disease) is an IgG4-related sclerosing disease characterized by persistent, usually painless, bilateral enlargement of the lacrimal, parotid, and submandibular glands associated with elevated levels of serum immunoglobulin (Ig) G4 and with lymphocyte and IgG4-positive plasmacyte infiltration. It predominantly causes mouth and eye dryness but can also affect other organs such as the lungs, liver, and kidneys, and be accompanied by complications such as autoimmune pancreatitis (AIP), retroperitoneal fibrosis, and tubulointerstitial nephritis."
      },
      "child_count": 0,
      "reference_id": "MONDO:0019191"
    }
  ],
  "roots": [
    {
      "id": 7019,
      "label": "eye disorder"
    },
    {
      "id": 17611,
      "label": "immunoglobulin G4-related sclerosing disease"
    }
  ]
}