{
  "id": 18713,
  "label": "oligodendroglial tumor",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0018744",
  "properties": {
    "xrefs": [
      "GARD:0013156",
      "MEDGEN:233266",
      "NCIT:C6960",
      "Orphanet:46484",
      "UMLS:C1335110"
    ],
    "synonyms": [
      "oligodendroglial neoplasm",
      "oligodendroglial tumor"
    ],
    "categories": [
      {
        "ref": "MONDO:0005071",
        "name": "nervous system disorder"
      }
    ],
    "definition": "Oligodendrogliomas are cerebral tumors that are differentiated from other gliomas on the basis of their unique genetic characteristics and better response to chemotherapy. These tumors are classified according to their grade (low grade oligodendrogliomas: grade II of the WHO classification and anaplastic oligodendrogliomas: grade III of the WHO classification) and according to their pure or mixed histology (oligoastrocytomas)."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 2,
  "parents": [
    {
      "id": 24071,
      "label": "malignant glioma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4753,
        20078,
        20287
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3070",
          "GARD:0026148",
          "ICDO:9380/3",
          "MEDGEN:107826",
          "MedDRA:10018338",
          "NCIT:C4822",
          "UMLS:C0555198"
        ],
        "synonyms": [
          "glioma",
          "neuroglial tumor",
          "neuroglial tumour",
          "glial cell tumour",
          "glioma, malignant",
          "high grade glioma",
          "high-grade glioma",
          "malignant glial neoplasm",
          "malignant glial tumor",
          "malignant glial tumour",
          "malignant glioma",
          "malignant neuroglial neoplasm",
          "malignant neuroglial tumor",
          "malignant neuroglial tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A grade III or grade IV glioma arising from the central nervous system. This category includes glioblastoma, anaplastic astrocytoma, anaplastic ependymoma, anaplastic oligodendroglioma, and anaplastic oligoastrocytoma."
      },
      "child_count": 36,
      "reference_id": "MONDO:0100342"
    }
  ],
  "children": [
    {
      "id": 17158,
      "label": "oligodendroglioma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        18713,
        20695
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3181",
          "EFO:0000632",
          "GARD:0009953",
          "ICDO:9450/3",
          "MEDGEN:45190",
          "MESH:D009837",
          "MedDRA:10030286",
          "NANDO:2200089",
          "NCIT:C3288",
          "ONCOTREE:ODG",
          "Orphanet:251627",
          "UMLS:C0028945"
        ],
        "synonyms": [
          "oligodendroglial neoplasm",
          "oligodendroglial tumor",
          "oligodendroglial tumour",
          "WHO grade II oligodendroglial neoplasm",
          "WHO grade II oligodendroglial tumor",
          "WHO grade II oligodendroglial tumour",
          "oligodendroglioma",
          "well differentiated oligodendroglial tumor",
          "well differentiated oligodendroglial tumour",
          "well differentiated oligodendroglioma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A well-differentiated (WHO grade II), diffusely infiltrating neuroglial tumor, typically located in the cerebral hemispheres. It is composed predominantly of cells which morphologically resemble oligodendroglia. The neoplastic cells have rounded homogeneous nuclei and, on paraffin sections, a swollen, clear cytoplasm ('honeycomb' appearance). (Adapted from WHO)"
      },
      "child_count": 8,
      "reference_id": "MONDO:0016695"
    },
    {
      "id": 17159,
      "label": "anaplastic oligodendroglioma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        18713,
        20048,
        20696
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7154",
          "EFO:0002501",
          "GARD:0009472",
          "ICDO:9451/3",
          "MEDGEN:90812",
          "MedDRA:10026659",
          "NCIT:C4326",
          "ONCOTREE:AODG",
          "Orphanet:251630",
          "UMLS:C0334590"
        ],
        "synonyms": [
          "WHO grade III oligodendroglial neoplasm",
          "WHO grade III oligodendroglial tumor",
          "WHO grade III oligodendroglial tumour",
          "anaplastic oligodendroglioma",
          "malignant oligodendroglioma",
          "oligodendroglioma, anaplastic, malignant",
          "oligodendroglioma, malignant",
          "undifferentiated oligodendroglioma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A WHO grade III oligodendroglioma with focal or diffuse malignant morphologic features (prominent nuclear pleomorphism, mitoses, and increased cellularity)."
      },
      "child_count": 3,
      "reference_id": "MONDO:0016696"
    }
  ],
  "roots": [
    {
      "id": 24071,
      "label": "malignant glioma"
    }
  ]
}