{
  "id": 18743,
  "label": "pediatric multiple sclerosis",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0018784",
  "properties": {
    "xrefs": [
      "GARD:0010443",
      "MEDGEN:1799994",
      "Orphanet:477738",
      "UMLS:C5568571"
    ],
    "synonyms": [
      "MS paediatric",
      "MS pediatric",
      "multiple sclerosis, paediatric",
      "multiple sclerosis, pediatric",
      "paediatric MS",
      "pediatric MS"
    ],
    "categories": [
      {
        "ref": "MONDO:0005046",
        "name": "immune system disorder"
      },
      {
        "ref": "MONDO:0005071",
        "name": "nervous system disorder"
      }
    ],
    "definition": "Pediatric multiple sclerosis (MS) is a rare multiple sclerosis variant characterized by the onset of multiple sclerosis (i.e. one or multiple episodes of clinical CNS symptoms consistent with acquired CNS demyelination, with radiologically proven dissemination of inflammatory lesions in space and time, following exclusion of other disorders) before the age of 18 years old. Pediatric MS patients present a predominantly relapsing-remitting course with first attack usually consisting of optic neuritis, transverse myelitis, acute disseminated encephalomyelitis and monofocal or polyfocal neurological deficits. A high burden of T2-hyperintense lesions on initial MRI, primarily of the supratentorial region and/or of the cervical spinal cord, has been reported."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 6995,
      "label": "multiple sclerosis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        2996,
        7209,
        8166,
        20199
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2377",
          "ICD10CM:G35",
          "ICD10WHO:G35",
          "ICD9:340",
          "MEDGEN:10123",
          "MESH:D009103",
          "NANDO:1200023",
          "NANDO:2100250",
          "NANDO:2200904",
          "NCIT:C3243",
          "Orphanet:802",
          "SCTID:24700007",
          "UMLS:C0026769",
          "icd11.foundation:1298865187"
        ],
        "synonyms": [
          "generalised multiple sclerosis",
          "generalized multiple sclerosis",
          "insular sclerosis"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A progressive autoimmune disorder affecting the central nervous system resulting in demyelination. Patients develop physical and cognitive impairments that correspond with the affected nerve fibers."
      },
      "child_count": 16,
      "reference_id": "MONDO:0005301"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 6995,
      "label": "multiple sclerosis"
    }
  ]
}