{
  "id": 18784,
  "label": "IgG4-related retroperitoneal fibrosis",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0018848",
  "properties": {
    "xrefs": [
      "GARD:0009568",
      "ICD9:593.4",
      "MEDGEN:20554",
      "MESH:D012185",
      "MedDRA:10038979",
      "NCIT:C26876",
      "NORD:1665",
      "Orphanet:49041",
      "SCTID:197808006",
      "UMLS:C0035357",
      "icd11.foundation:900354709"
    ],
    "synonyms": [
      "Ormond disease",
      "Retroperitoneal Fibrosis",
      "idiopathic retroperitoneal fibrosis",
      "retroperitoneal fibrosis",
      "Ormond's disease"
    ],
    "categories": [
      {
        "ref": "MONDO:0005046",
        "name": "immune system disorder"
      }
    ],
    "definition": "Retroperitoneal fibrosis (RPF) is characterized by the development of a fibrotic mass surrounding retroperitoneal structures, such as aorta, vena cava, ureters and psoas muscle."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 1,
  "parents": [
    {
      "id": 17611,
      "label": "immunoglobulin G4-related sclerosing disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        8586
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0080356",
          "GARD:0012521",
          "MEDGEN:473761",
          "MedDRA:10071569",
          "NANDO:1200923",
          "NANDO:1200924",
          "NCIT:C95992",
          "Orphanet:284264",
          "Orphanet:596448",
          "UMLS:C3203653",
          "icd11.foundation:99883782"
        ],
        "synonyms": [
          "IgG4-RD",
          "IgG4-related disease",
          "IgG4-related sclerosing disease",
          "IgG4-related systemic disease",
          "immunoglobulin G4-related sclerosing disease",
          "IgG4-associated disease",
          "IgG4-positive multiorgan lymphoproliferative syndrome",
          "IgG4-related autoimmune disease",
          "IgG4-related systemic sclerosing disease",
          "IgG4-syndrome",
          "hyper-IgG4 disease",
          "multifocal fibrosclerosis",
          "multifocal idiopathic fibrosclerosis",
          "systemic IgG4-related plasmacytic syndrome",
          "systemic IgG4-related sclerosing syndrome"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ],
        "definition": "A recently described mass-forming lesion that occurs in the pancreas, submandibular glands, lacrimal glands, lymph nodes, and hepatobiliary tract. It is characterized by the presence of marked tissue sclerosis and infiltration by numerous plasma cells. The plasma cells show immunohistochemical staining for IgG4 and the serum IgG4 levels are often increased."
      },
      "child_count": 14,
      "reference_id": "MONDO:0017287"
    }
  ],
  "children": [
    {
      "id": 10473,
      "label": "fibrosclerosis, multifocal",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5714,
        18784
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0005697",
          "ICD10CM:M35.5",
          "ICD9:710.8",
          "MEDGEN:105414",
          "MESH:C537375",
          "OMIM:228800",
          "SCTID:111210001",
          "UMLS:C0494949"
        ],
        "synonyms": [
          "fibrosclerosis, multifocal",
          "mediastinal fibrosis, familial",
          "multifocal fibrosclerosis",
          "retroperitoneal fibrosis, familial"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0009230"
    }
  ],
  "roots": [
    {
      "id": 17611,
      "label": "immunoglobulin G4-related sclerosing disease"
    }
  ]
}