{
  "id": 18787,
  "label": "familial keratoacanthoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0018851",
  "properties": {
    "xrefs": [
      "GARD:0018693",
      "MEDGEN:1843863",
      "Orphanet:493",
      "SCTID:716774008",
      "UMLS:C5848325"
    ],
    "synonyms": [
      "hereditary keratoacanthoma",
      "multiple keratoacanthoma"
    ],
    "categories": [
      {
        "ref": "MONDO:0002051",
        "name": "integumentary system disorder"
      }
    ],
    "definition": "Multiple familial keratoacanthoma (KA) of Witten and Zak is a rare a rare inherited skin cancer syndrome and is characterized by the coexistence of features characteristic of both multiple KA, Ferguson Smith type and generalized eruptive keratoacanthoma, such as multiple small miliary-type lesions, larger self-healing lesions, and nodulo-ulcerative lesions. Lesions do not have a predilection for the mucosal surfaces. Transmission is autosomal dominant."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 4596,
      "label": "keratoacanthoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        20690
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3149",
          "ICDO:8071/1",
          "MEDGEN:5954",
          "MESH:D007636",
          "NCIT:C3146",
          "SCTID:254662007",
          "UMLS:C0022572",
          "icd11.foundation:516478127"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ],
        "definition": "A dome-shaped, rapidly growing skin lesion composed of well differentiated squamous cells. It represents a proliferation of the infundibular epithelium of the hair follicle and its morphologic distinction from a well differentiated carcinoma may be difficult or impossible. Keratoacanthomas affect males more frequently than females and the majority tend to regress spontaneously. It has been suggested that keratoacanthoma represents a distinct subtype of squamous cell carcinoma of the skin."
      },
      "child_count": 2,
      "reference_id": "MONDO:0002527"
    },
    {
      "id": 23867,
      "label": "hereditary skin disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5714,
        6820
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MESH:D012873",
          "SCTID:239001006"
        ],
        "synonyms": [
          "disease, genetic skin",
          "diseases, genetic skin",
          "genetic skin disease",
          "genetic skin diseases",
          "genodermatosis",
          "skin disease, genetic"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ],
        "definition": "An instance of skin disease that is caused by a modification of the individual's genome."
      },
      "child_count": 228,
      "reference_id": "MONDO:0100118"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 4596,
      "label": "keratoacanthoma"
    },
    {
      "id": 23867,
      "label": "hereditary skin disorder"
    }
  ]
}