{
  "id": 18802,
  "label": "arterial calcification of infancy",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0018870",
  "properties": {
    "xrefs": [
      "DOID:0050644",
      "GARD:0008380",
      "MEDGEN:395331",
      "MESH:C537440",
      "NORD:2001",
      "OMIMPS:208000",
      "Orphanet:51608",
      "UMLS:C1859727",
      "icd11.foundation:934461548"
    ],
    "synonyms": [
      "Generalized Arterial Calcification of Infancy",
      "generalised arterial calcification of infancy",
      "generalized arterial calcification of infancy",
      "idiopathic infantile arterial calcification",
      "idiopathic obliterative arteriopathy",
      "infantile arteriosclerosis",
      "occlusive infantile arteriopathy",
      "IIAC",
      "generalised arterial calcification in infancy",
      "generalized arterial calcification in infancy"
    ],
    "categories": [
      {
        "ref": "MONDO:0004995",
        "name": "cardiovascular disorder"
      }
    ],
    "definition": "Idiopathic arterial calcification of infancy is a rare condition characterized by extensive calcification and stenosis of the large and medium sized arteries."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 2,
  "parents": [
    {
      "id": 5714,
      "label": "hereditary disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        29382
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:630",
          "EFO:0000508",
          "ICD9:799.89",
          "MEDGEN:5527",
          "MESH:D030342",
          "NCIT:C3101",
          "SCTID:32895009",
          "UMLS:C0019247"
        ],
        "synonyms": [
          "genetic condition",
          "genetic disease",
          "genetic disorder",
          "hereditary disease",
          "hereditary disease or disorder",
          "hereditary diseases",
          "inherited disease",
          "inherited genetic disease",
          "molecular disease",
          "Mendelian disease",
          "familial disorder",
          "inborn disorder"
        ],
        "definition": "A disease that is caused by genetic modifications where those modifications are inherited from a parent's genome."
      },
      "child_count": 1925,
      "reference_id": "MONDO:0003847"
    },
    {
      "id": 7065,
      "label": "vascular disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6736
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:178",
          "EFO:0004264",
          "ICD10CM:I00-I99",
          "ICD10CM:I70-I79",
          "ICD9:442.9",
          "MEDGEN:22621",
          "MESH:D014652",
          "NANDO:2100294",
          "NCIT:C35117",
          "SCTID:27550009",
          "UMLS:C0042373"
        ],
        "synonyms": [
          "disease of vasculature",
          "disease or disorder of vasculature",
          "disorder of vasculature",
          "vascular disorder",
          "vasculature disease",
          "vasculature disease or disorder",
          "vasculopathy"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "A general term used to describe any disease affecting blood vessels]. It includes vascular abnormalities caused by degenerative, metabolic and inflammatory conditions, embolic diseases, coagulative disorders, and functional disorders such as posteri or reversible encephalopathy syndrome."
      },
      "child_count": 60,
      "reference_id": "MONDO:0005385"
    }
  ],
  "children": [
    {
      "id": 10085,
      "label": "arterial calcification, generalized, of infancy, 1",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        18802
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0024642",
          "MEDGEN:1631685",
          "NCIT:C128805",
          "OMIM:208000",
          "UMLS:C4551985"
        ],
        "synonyms": [
          "ENPP1 arterial calcification of infancy",
          "arterial calcification of infancy caused by mutation in ENPP1",
          "arterial calcification, generalized, of infancy, 1",
          "arterial calcification, generalized, of infancy, type 1",
          "generalised arterial calcification of infancy 1",
          "generalized arterial calcification of infancy 1",
          "GACI1",
          "Gaci",
          "arterial calcification, idiopathic infantile",
          "arteriopathy, occlusive infantile",
          "coronary sclerosis, medial, of infancy",
          "idiopathic infantile arterial calcification"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "An autosomal recessive genetic disorder caused by mutations in the ENPP1 gene, encoding ectonucleotide pyrophosphatase/phosphodiesterase family member 1. The condition is characterized by calcification and narrowing of medium- and large-sized arteries, resulting in cardiovascular complications."
      },
      "child_count": 0,
      "reference_id": "MONDO:0008817"
    },
    {
      "id": 14786,
      "label": "arterial calcification, generalized, of infancy, 2",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        18802
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0024947",
          "MEDGEN:477791",
          "OMIM:614473",
          "UMLS:C3276161"
        ],
        "synonyms": [
          "ABCC6 arterial calcification of infancy",
          "arterial calcification of infancy caused by mutation in ABCC6",
          "arterial calcification, generalized, of infancy, 2",
          "arterial calcification, generalized, of infancy, type 2",
          "GACI2"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "Any arterial calcification of infancy in which the cause of the disease is a mutation in the ABCC6 gene."
      },
      "child_count": 0,
      "reference_id": "MONDO:0013768"
    }
  ],
  "roots": [
    {
      "id": 5714,
      "label": "hereditary disease"
    },
    {
      "id": 7065,
      "label": "vascular disorder"
    }
  ]
}