{
  "id": 18804,
  "label": "acute megakaryoblastic leukemia",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0018872",
  "properties": {
    "xrefs": [
      "DOID:8761",
      "EFO:0003025",
      "GARD:0000524",
      "ICD10CM:C94.2",
      "ICD9:207.2",
      "ICDO:9910/3",
      "MEDGEN:44124",
      "MESH:D007947",
      "MedDRA:10060556",
      "NANDO:2200011",
      "NCIT:C3170",
      "ONCOTREE:AMKL",
      "Orphanet:518",
      "SCTID:277602003",
      "UMLS:C0023462",
      "Wikipedia:Acute_megakaryoblastic_leukemia",
      "icd11.foundation:2057381869"
    ],
    "synonyms": [
      "AMKL",
      "AML M7",
      "FAB M7",
      "acute M7 myeloid leukaemia",
      "acute M7 myeloid leukemia",
      "acute megakaryoblastic leukaemia (FAB type M7)",
      "acute megakaryoblastic leukemia",
      "acute megakaryoblastic leukemia (FAB type M7)",
      "acute megakaryoblastic leukemia, FAB M7",
      "acute megakaryocytic leukaemia",
      "acute megakaryocytic leukemia",
      "acute megakaryocytic leukemias",
      "acute myeloid leukaemia M7",
      "acute myeloid leukemia M7",
      "leukemia, megakaryocytic, malignant",
      "thrombocytic leukemia",
      "acute myeloblastic leukaemia type 7",
      "acute myeloblastic leukemia type 7",
      "megakaryocytic leukaemia",
      "megakaryocytic leukemia"
    ],
    "categories": [
      {
        "ref": "MONDO:0002081",
        "name": "musculoskeletal system disorder"
      },
      {
        "ref": "MONDO:0003900",
        "name": "connective tissue disorder"
      },
      {
        "ref": "MONDO:0005046",
        "name": "immune system disorder"
      },
      {
        "ref": "MONDO:0005570",
        "name": "hematologic disorder"
      }
    ],
    "definition": "Acute megakaryoblastic leukemia (AMKL) is a form of acute myeloid leukemia (AML) that occurs predominantly in childhood and particularly in children with Down syndrome (DS-AMKL). Nonspecific symptoms may be irritability, weakness, and dizziness while specific symptoms include pallor, fever, mucocutaneous bleeding, hepatosplenomegaly, neurological manifestations and rarely lymphadenopathy. Acute panmyelosis with myelofibrosis may also be associated with AMKL. In contrast to DS-AMKL (around 80 % survival), non-DS-AMKL is an AML subgroup associated with poor prognosis."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 5,
  "parents": [
    {
      "id": 16444,
      "label": "acute myeloid leukemia by FAB classification",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        18806
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0012760",
          "MEDGEN:1842303",
          "NCIT:C27753",
          "Orphanet:167714",
          "UMLS:C5679583"
        ],
        "synonyms": [
          "acute myeloid leukaemia",
          "acute myeloid leukemia",
          "AML, NOS",
          "acute myeloid leukaemia NOS",
          "acute myeloid leukaemia not otherwise categorised",
          "acute myeloid leukaemia not otherwise specified",
          "acute myeloid leukemia NOS",
          "acute myeloid leukemia not otherwise categorized",
          "acute myeloid leukemia not otherwise specified",
          "acute myeloid leukemia, NOS",
          "unclassified AML",
          "unclassified acute myeloid leukaemia",
          "unclassified acute myeloid leukemia"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "Acute myeloid leukemias that do not fulfill the criteria for inclusion in the group of acute myeloid leukemias which have recurrent genetic abnormalities or myelodysplastic changes, or are therapy-related. This category includes entities classified according to the French-American-British classification scheme."
      },
      "child_count": 9,
      "reference_id": "MONDO:0015667"
    }
  ],
  "children": [
    {
      "id": 18179,
      "label": "acute megakaryoblastic leukemia without down syndrome",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        18804
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0021490",
          "MEDGEN:1843134",
          "Orphanet:329469",
          "UMLS:C5679860"
        ],
        "synonyms": [
          "non-DS-AMKL"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0018004"
    },
    {
      "id": 19973,
      "label": "acute megakaryoblastic leukemia in down syndrome",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        18804
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0019697",
          "MEDGEN:1863778",
          "Orphanet:99887",
          "UMLS:C5925108"
        ],
        "synonyms": [
          "DS-AMKL"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0020526"
    },
    {
      "id": 25182,
      "label": "childhood acute megakaryoblastic leukemia",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        18804
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0080794",
          "GARD:0026595",
          "MEDGEN:79023",
          "NCIT:C7972",
          "UMLS:C0279650"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "An acute megakaryocytic leukemia that is characterized by fusion oncogenes involving transcriptional regulators in childhood."
      },
      "child_count": 0,
      "reference_id": "MONDO:0850267"
    },
    {
      "id": 25184,
      "label": "myeloid leukemia associated with down syndrome",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        18804
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0080798",
          "GARD:0026597",
          "MEDGEN:416725",
          "NCIT:C43223",
          "UMLS:C2825149"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "An acute megakaryocytic leukemia occurring in children with Down syndrome and that has material basis in mutation in the GATA1 gene."
      },
      "child_count": 0,
      "reference_id": "MONDO:0850271"
    },
    {
      "id": 26040,
      "label": "acute megakaryoblastic leukemia in adult",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        18804
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0027172",
          "MEDGEN:79016",
          "Orphanet:662934",
          "UMLS:C0279632"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0971091"
    }
  ],
  "roots": [
    {
      "id": 16444,
      "label": "acute myeloid leukemia by FAB classification"
    }
  ]
}