{
  "id": 18813,
  "label": "vasculitis",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0018882",
  "properties": {
    "xrefs": [
      "DOID:865",
      "EFO:0006803",
      "GARD:0018844",
      "MEDGEN:12054",
      "MESH:D014657",
      "MedDRA:10036023",
      "MedDRA:10047115",
      "NCIT:C26912",
      "Orphanet:52759",
      "SCTID:31996006",
      "UMLS:C0042384",
      "Wikipedia:Vasculitis",
      "icd11.foundation:572581721"
    ],
    "synonyms": [
      "systemic vasculitis",
      "angiitis"
    ],
    "categories": [
      {
        "ref": "MONDO:0004995",
        "name": "cardiovascular disorder"
      }
    ],
    "definition": "Vasculitis represents a clinically heterogenous group of diseases of multifactorial etiology characterized by inflammation of either large-sized vessels (large-vessel vasculitis, e.g. Giant-cell arteritis and Takayasu arteritis), medium-sized vessels (medium-vessel vasculitis e.g. polyarteritis nodosa and Kawasaki disease), or small-sized vessels (small-vessel vasculitis, e.g. granulomatosis with polyangiitis, microscopic polyangiitis, immunoglobulin A vasculitis, and cutaneous leukocytoclastic angiitis). Vasculitis occurs at any age, may be acute or chronic, and manifests with general symptoms such as fever, weight loss and fatigue, as well as more specific clinical signs depending on the type of vessels and organs affected. The degree of severity is variable, ranging from life or sight threatening disease (e.g. Behcet disease) to relatively minor skin disease."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 18,
  "parents": [
    {
      "id": 7065,
      "label": "vascular disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6736
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:178",
          "EFO:0004264",
          "ICD10CM:I00-I99",
          "ICD10CM:I70-I79",
          "ICD9:442.9",
          "MEDGEN:22621",
          "MESH:D014652",
          "NANDO:2100294",
          "NCIT:C35117",
          "SCTID:27550009",
          "UMLS:C0042373"
        ],
        "synonyms": [
          "disease of vasculature",
          "disease or disorder of vasculature",
          "disorder of vasculature",
          "vascular disorder",
          "vasculature disease",
          "vasculature disease or disorder",
          "vasculopathy"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "A general term used to describe any disease affecting blood vessels]. It includes vascular abnormalities caused by degenerative, metabolic and inflammatory conditions, embolic diseases, coagulative disorders, and functional disorders such as posteri or reversible encephalopathy syndrome."
      },
      "child_count": 60,
      "reference_id": "MONDO:0005385"
    },
    {
      "id": 20399,
      "label": "inflammatory disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        29380
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "ICD9:799.89",
          "MEDGEN:452939",
          "NCIT:C93210",
          "SCTID:128139000",
          "UMLS:C1290884"
        ],
        "synonyms": [
          "anatomical structure inflammation",
          "inflammation of anatomical structure",
          "inflammatory disease",
          "inflammatory disorder"
        ],
        "definition": "A disease involving a pathogenic inflammatory response in the anatomical structure."
      },
      "child_count": 94,
      "reference_id": "MONDO:0021166"
    }
  ],
  "children": [
    {
      "id": 3514,
      "label": "choroiditis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4072,
        8351,
        18813
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:11406",
          "GARD:0004457",
          "HP:0012123",
          "MEDGEN:40282",
          "MESH:D002833",
          "MedDRA:10036370",
          "NCIT:C35111",
          "NORD:1601",
          "Orphanet:280892",
          "SCTID:16553002",
          "UMLS:C0008526",
          "icd11.foundation:1884626736"
        ],
        "synonyms": [
          "Choroiditides",
          "choroiditis",
          "Posterior Uveitis",
          "posterior uveitis",
          "posterior uveitis (disease)"
        ],
        "categories": [
          {
            "ref": "MONDO:0002022",
            "name": "disorder of orbital region"
          },
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          },
          {
            "ref": "MONDO:0024458",
            "name": "disorder of visual system"
          }
        ],
        "definition": "An inflammatory process that affects the choroid."
      },
      "child_count": 12,
      "reference_id": "MONDO:0001280"
    },
    {
      "id": 4812,
      "label": "Shwartzman phenomenon",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5128,
        18813
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3825",
          "GARD:0007636",
          "MEDGEN:48656",
          "MESH:D012790",
          "UMLS:C0037018"
        ],
        "synonyms": [
          "Shwartzman reaction (function)"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "Hemorrhagic necrosis that was first demonstrated in rabbits with a two-step reaction, an initial local (intradermal) or general (intravenous) injection of a priming endotoxin (endotoxins) followed by a second intravenous endotoxin injection (provoking agent) 24 h later. The acute inflammation damages the small blood vessels. The following intravascular coagulation leads to capillary and venous thrombosis and necrosis. Shwartzman phenomenon can also occur in other species with a single injection of a provoking agent, and during infections or pregnancy. Its susceptibility depends on the status of immune system, coagulation, fibrinolysis, and blood flow."
      },
      "child_count": 0,
      "reference_id": "MONDO:0002783"
    },
    {
      "id": 5281,
      "label": "central nervous system vasculitis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4657,
        18813,
        23165
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:525",
          "GARD:0023462",
          "MEDGEN:148408",
          "MESH:D020293",
          "NCIT:C84622",
          "UMLS:C0751878"
        ],
        "synonyms": [
          "central nervous system vasculitis",
          "vasculitis of central nervous system"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Vasculitis affecting the blood vessels of the brain and/or spinal cord."
      },
      "child_count": 15,
      "reference_id": "MONDO:0003346"
    },
    {
      "id": 6413,
      "label": "phlebitis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6420,
        18813
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:864",
          "EFO:1001395",
          "MEDGEN:18425",
          "MESH:D010689",
          "NCIT:C38003",
          "SCTID:61599003",
          "UMLS:C0031542"
        ],
        "synonyms": [
          "inflammation of vein",
          "vein inflammation"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "Inflammation of a vein."
      },
      "child_count": 2,
      "reference_id": "MONDO:0004625"
    },
    {
      "id": 7446,
      "label": "lymphangitis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7447,
        18813
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:9317",
          "EFO:0007351",
          "GARD:0024239",
          "ICD10CM:I89.1",
          "ICD9:457.2",
          "MEDGEN:7412",
          "MESH:D008205",
          "NCIT:C34790",
          "SCTID:1415005",
          "UMLS:C0024225",
          "icd11.foundation:1548743622"
        ],
        "synonyms": [
          "inflammation of lymphatic vessel",
          "lymphatic vessel inflammation"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ],
        "definition": "Inflammation of the lymphatic vessels."
      },
      "child_count": 0,
      "reference_id": "MONDO:0005832"
    },
    {
      "id": 8128,
      "label": "aortitis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7210,
        18813
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:519",
          "EFO:1000816",
          "GARD:0024455",
          "MEDGEN:8154",
          "MESH:D001025",
          "MedDRA:10002921",
          "NANDO:1200251",
          "NANDO:2200423",
          "NCIT:C97085",
          "SCTID:70933002",
          "UMLS:C0003509"
        ],
        "synonyms": [
          "aorta inflammation",
          "inflammation of aorta"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "Inflammation of the aorta. Causes include trauma, infectious disorders, and connective tissue disorders."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006656"
    },
    {
      "id": 8242,
      "label": "hypersensitivity vasculitis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3018,
        18813
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:9809",
          "EFO:1000974",
          "GARD:0024475",
          "ICD9:446.2",
          "ICD9:446.20",
          "ICD9:446.29",
          "MEDGEN:445500",
          "MedDRA:10020764",
          "NCIT:C82863",
          "SCTID:60555002",
          "UMLS:C2973529"
        ],
        "synonyms": [
          "leukocytoclastic vasculitis"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ],
        "definition": "A small vessel vasculitis affecting the skin and/or internal organs. It is characterized by the presence of neutrophils and fibrinoid necrosis in small arteries and venules. It may be idiopathic or the result of drug treatment, infections, food intake, collagen vascular disorders, inflammatory bowel disease, or cancer."
      },
      "child_count": 4,
      "reference_id": "MONDO:0006794"
    },
    {
      "id": 8379,
      "label": "retinal vasculitis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4419,
        4749,
        18813
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:11563",
          "EFO:1001156",
          "GARD:0024505",
          "ICD10CM:H35.06",
          "ICD9:362.18",
          "MEDGEN:57503",
          "MESH:D031300",
          "MedDRA:10038905",
          "SCTID:77628002",
          "UMLS:C0152026",
          "icd11.foundation:1863208483"
        ],
        "synonyms": [
          "retinal vasculitis"
        ],
        "categories": [
          {
            "ref": "MONDO:0002022",
            "name": "disorder of orbital region"
          },
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0024458",
            "name": "disorder of visual system"
          }
        ],
        "definition": "Inflammation of the retinal vasculature with various causes including infectious disease; lupus erythematosus, systemic; multiple sclerosis; behcet syndrome; and chorioretinitis."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006950"
    },
    {
      "id": 9922,
      "label": "vasculitis, lymphocytic, nodular",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        18813,
        23867
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0006941",
          "MEDGEN:348635",
          "MESH:C566008",
          "OMIM:192310",
          "UMLS:C1860519"
        ],
        "synonyms": [
          "vasculitis, lymphocytic, nodular",
          "lymphocytic vasculitis",
          "vasculitis lymphocytic, nodular"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "Lymphocytic vasculitis is one of several skin conditions which are collectively referred to as cutaneous vasculitis. In lymphocytic vasculitis, white blood cells (lymphocytes) cause damage to blood vessels in the skin. This condition is thought to be caused by a number of factors, but the exact cause of most cases is not known. This disease can present with a variety of symptoms, depending on the size, location, and severity of the affected area. In a minority of patients, cutaneous vasculitis can be part of a more severe vasculitis affecting other organs in the body - this is known as systemic vasculitis."
      },
      "child_count": 0,
      "reference_id": "MONDO:0008640"
    },
    {
      "id": 13767,
      "label": "Kawasaki disease",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4199,
        18813
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:13378",
          "EFO:0004246",
          "GARD:0006816",
          "ICD10CM:M30.3",
          "ICD9:446.1",
          "MEDGEN:10118",
          "MESH:D009080",
          "MedDRA:10023320",
          "NCIT:C34825",
          "OMIM:611775",
          "Orphanet:2331",
          "SCTID:75053002",
          "UMLS:C0026691",
          "icd11.foundation:540285662"
        ],
        "synonyms": [
          "Kawasaki syndrome",
          "acute febrile mucocutaneous lymph node syndrome",
          "acute febrile mucocutaneous lymph node syndrome [MCLS]",
          "infantile polyarteritis nodosa",
          "mucocutaneous lymph node syndrome"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ],
        "definition": "A rare inflammatory disease characterized by an acute febrile, systemic, self-limiting, medium-vessel vasculitis primarily affecting children. It often causes acute coronary arteritis which is associated with coronary arterial aneurysms (CAA) that may be life threatening when untreated."
      },
      "child_count": 0,
      "reference_id": "MONDO:0012727"
    },
    {
      "id": 15310,
      "label": "deficiency of adenosine deaminase 2",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        18813,
        21247,
        25666
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0012383",
          "MEDGEN:854497",
          "NANDO:1200995",
          "NANDO:2200441",
          "NANDO:2200450",
          "OMIM:615688",
          "Orphanet:404553",
          "UMLS:C3887654"
        ],
        "synonyms": [
          "ADA2 deficiency",
          "DADA2",
          "adenosine deaminase 2 deficiency",
          "childhood-onset polyarteritis nodosa",
          "deficiency of adenosine deaminase 2",
          "polyarteritis nodosa, childhood-onset",
          "vasculitis, autoinflammation, immunodeficiency, and hematologic defects syndrome",
          "PAN"
        ],
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "A rare autoinflammatory disease characterized by a broad clinical phenotype of systemic inflammation, vasculitis, early-onset stroke, immunodeficiency and bone marrow failure. The disease typically presents in young children, although adult cases are being discovered."
      },
      "child_count": 0,
      "reference_id": "MONDO:0014306"
    },
    {
      "id": 16323,
      "label": "immune complex mediated vasculitis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        18813
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0019984",
          "MEDGEN:1842565",
          "Orphanet:156149",
          "UMLS:C5680655"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ]
      },
      "child_count": 5,
      "reference_id": "MONDO:0015491"
    },
    {
      "id": 18637,
      "label": "secondary vasculitis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        18813
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0021863",
          "MEDGEN:1842960",
          "Orphanet:445197",
          "UMLS:C5681200"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ]
      },
      "child_count": 2,
      "reference_id": "MONDO:0018640"
    },
    {
      "id": 20014,
      "label": "cutaneous vasculitis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4496,
        18813
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0025172",
          "MEDGEN:488809",
          "NCIT:C112210",
          "UMLS:C0262988"
        ],
        "synonyms": [
          "cutaneous vasculitis"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "Inflammation of the blood vessel wall characterized by palpable purpura."
      },
      "child_count": 2,
      "reference_id": "MONDO:0020576"
    },
    {
      "id": 21710,
      "label": "livedoid vasculopathy",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6820,
        18813
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0040099",
          "GARD:0012784",
          "ICD10CM:L95.0",
          "ICD9:709.1",
          "ICD9CM:709.1",
          "MEDGEN:575376",
          "MESH:D000090122",
          "Orphanet:542643",
          "SCTID:238762002",
          "UMLS:C0343081",
          "icd11.foundation:1237292304"
        ],
        "synonyms": [
          "livedoid vasculitis",
          "livedoid vasculopathy",
          "idiopathic atrophic blanche",
          "livedo reticularis with summer ulcerations",
          "livedo reticularis with winter ulcerations",
          "livedo vasculitis",
          "segmental hyalinizing vasculopathy",
          "white atrophy"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "Livedoid vasculopathy is a blood vessel disorder that causes painful ulcers and scarring (atrophie blanche) on the feet and lower legs. These symptoms can persist for months to years and the ulcers often recur.Livedoid vasculopathy lesions appear as painful red or purple marks and spots that may progress to small, tender, irregular ulcers. Symptoms tend to worsen in the winter and summer months, and affect women more often then men. Livedoid vasculopathy may occur alone or in combination with another condition, such as lupus or thrombophilia."
      },
      "child_count": 0,
      "reference_id": "MONDO:0025514"
    },
    {
      "id": 22010,
      "label": "autoimmune vasculitis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3017,
        18813
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0040097",
          "GARD:0025618",
          "MEDGEN:730236",
          "SCTID:427213005",
          "UMLS:C1328843"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ],
        "definition": "An autoimmune form of vasculitis."
      },
      "child_count": 2,
      "reference_id": "MONDO:0030703"
    },
    {
      "id": 23218,
      "label": "arteritis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        2933,
        18813
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:0009011",
          "HP:0012089",
          "MEDGEN:13916",
          "MESH:D001167",
          "NCIT:C34399",
          "SCTID:52089001",
          "UMLS:C0003860"
        ],
        "synonyms": [
          "arteritis",
          "artery inflammation",
          "inflammation of artery",
          "Arteritides",
          "Inflammation, arterial",
          "arterial Inflammation"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "An inflammatory process affecting an artery."
      },
      "child_count": 14,
      "reference_id": "MONDO:0043494"
    },
    {
      "id": 24822,
      "label": "necrotizing vasculitis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        18813
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0005106",
          "MEDGEN:230813",
          "NCIT:C70635",
          "UMLS:C1318520"
        ],
        "synonyms": [
          "systemic vasculitis"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "A type of vasculitis that is comprised of vasculitides that present with necrosis."
      },
      "child_count": 3,
      "reference_id": "MONDO:0800113"
    }
  ],
  "roots": [
    {
      "id": 7065,
      "label": "vascular disorder"
    },
    {
      "id": 20399,
      "label": "inflammatory disease"
    }
  ]
}