{
  "id": 18824,
  "label": "thrombotic thrombocytopenic purpura",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0018896",
  "properties": {
    "xrefs": [
      "DOID:10772",
      "GARD:0016659",
      "MEDGEN:48266",
      "MESH:D011697",
      "MedDRA:10043648",
      "NANDO:1200316",
      "NANDO:2100189",
      "NANDO:2200649",
      "NCIT:C78797",
      "NORD:1769",
      "Orphanet:54057",
      "SCTID:78129009",
      "UMLS:C0034155",
      "icd11.foundation:1708277768"
    ],
    "synonyms": [
      "Moschcowitz disease",
      "Moschowitz disease",
      "TTP"
    ],
    "categories": [
      {
        "ref": "MONDO:0005046",
        "name": "immune system disorder"
      },
      {
        "ref": "MONDO:0005570",
        "name": "hematologic disorder"
      }
    ],
    "definition": "Thrombotic thrombocytopenic purpura (TTP) is an aggressive and life-threatening form of thrombotic microangiopathy (TMA) characterized by profound peripheral thrombocytopenia, microangiopathic hemolytic anemia (MAHA) and organ failure of variable severity and is comprised of congenital TTP and acquired TTP."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 2,
  "parents": [
    {
      "id": 4413,
      "label": "thrombophilia",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3738
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2452",
          "EFO:0009315",
          "GARD:0023114",
          "ICD9:286.9",
          "MEDGEN:98306",
          "MESH:D019851",
          "NCIT:C84479",
          "Orphanet:64738",
          "SCTID:234467004",
          "UMLS:C0398623",
          "icd11.foundation:1733531851"
        ],
        "synonyms": [
          "excessive blood clotting",
          "hypercoagulability",
          "hypercoagulability state",
          "hypercoagulable"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A condition characterized by an abnormally high level of thrombi. Causes include thrombotic thrombocytopenic purpura, disseminated intravascular coagulation, bone marrow disorders, and antiphospholipid antibody syndrome."
      },
      "child_count": 4,
      "reference_id": "MONDO:0002305"
    },
    {
      "id": 23244,
      "label": "thrombocytopenic purpura",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4196,
        4662,
        6778,
        19495
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0025866",
          "MEDGEN:208992",
          "MESH:D011696",
          "NANDO:2100188",
          "NCIT:C26870",
          "SCTID:302873008",
          "UMLS:C0857305"
        ],
        "synonyms": [
          "thrombocytopenic purpura",
          "purpura, thrombopenic",
          "purpuras, thrombocytopenic",
          "purpuras, thrombopenic",
          "thrombocytopenic purpuras",
          "thrombopenic purpura",
          "thrombopenic purpuras"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "Purpura associated with a reduction in circulating blood platelets which can result from a variety of factors."
      },
      "child_count": 8,
      "reference_id": "MONDO:0043768"
    }
  ],
  "children": [
    {
      "id": 11306,
      "label": "congenital thrombotic thrombocytopenic purpura",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        2702,
        10564,
        18824,
        20411,
        23981
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0009430",
          "ICD9:287.33",
          "MEDGEN:224783",
          "NANDO:1200317",
          "NCIT:C131657",
          "OMIM:274150",
          "Orphanet:93583",
          "SCTID:373420004",
          "UMLS:C1268935"
        ],
        "synonyms": [
          "Upshaw-Schulman syndrome",
          "congenital ADAMTS-13 deficiency",
          "congenital ADAMTS13 deficiency",
          "congenital TTP",
          "congenital thrombotic thrombocytopenic purpura",
          "familial TTP",
          "hereditary thrombotic thrombocytopenic purpura",
          "thrombotic thrombocytopenic purpura, hereditary",
          "Microangiopathic hemolytic Anaemia",
          "Microangiopathic hemolytic Anemia",
          "Microangiopathic hemolytic Anemia, congenital",
          "Schulman-Upshaw syndrome",
          "TTP",
          "TTP, congenital",
          "USS",
          "Upshaw Factor, deficiency of",
          "thrombotic microangiopathy, familial",
          "thrombotic thrombocytopenic purpura, congenital",
          "thrombotic thrombocytopenic purpura, familial"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "Congenital thrombotic thrombocytopenic purpura is the hereditary form of thrombotic thrombocytopenic purpura (TTP) characterized by profound peripheral thrombocytopenia, microangiopathic hemolytic anemia (MAHA) and single or multiple organ failure of variable severity."
      },
      "child_count": 0,
      "reference_id": "MONDO:0010122"
    },
    {
      "id": 19498,
      "label": "acquired thrombotic thrombocytopenic purpura",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        3439,
        18824
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0004607",
          "MEDGEN:391723",
          "MESH:C536901",
          "NANDO:1200318",
          "NANDO:1200319",
          "NCIT:C131653",
          "Orphanet:93585",
          "SCTID:438476003",
          "UMLS:C2584778"
        ],
        "synonyms": [
          "TTP",
          "purpura, thrombotic thrombocytopenic",
          "acquired ADAMTS13 deficiency",
          "acquired TTP",
          "acquired thrombotic thrombocytopenic purpura",
          "autoimmune thrombotic thrombocytopenic purpura",
          "Moschowitz syndrome",
          "idiopathic thrombotic thrombocytopenic purpura"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "Acquired thrombotic thrombocytopenic purpura is the non-hereditary form of thrombotic thrombocytopenic purpura (TTP), characterized by profound peripheral thrombocytopenia, microangiopathic hemolytic anemia (MAHA) and single or multiple organ failure of variable severity."
      },
      "child_count": 0,
      "reference_id": "MONDO:0019740"
    }
  ],
  "roots": [
    {
      "id": 4413,
      "label": "thrombophilia"
    },
    {
      "id": 23244,
      "label": "thrombocytopenic purpura"
    }
  ]
}