{
  "id": 18829,
  "label": "left ventricular noncompaction",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0018901",
  "properties": {
    "xrefs": [
      "DOID:0060480",
      "GARD:0010985",
      "MEDGEN:450531",
      "NANDO:2200231",
      "NCIT:C99544",
      "OMIMPS:604169",
      "Orphanet:54260",
      "UMLS:C1960469"
    ],
    "synonyms": [
      "LVNC",
      "Lv non-compaction syndrome",
      "left ventricular hypertrabeculation",
      "left ventricular non-compaction cardiomyopathy",
      "left ventricular non-compaction syndrome",
      "left ventricular noncompaction (disease)",
      "spongy myocardium"
    ],
    "categories": [
      {
        "ref": "MONDO:0002081",
        "name": "musculoskeletal system disorder"
      },
      {
        "ref": "MONDO:0002254",
        "name": "syndromic disease"
      },
      {
        "ref": "MONDO:0004995",
        "name": "cardiovascular disorder"
      }
    ],
    "definition": "Left ventricular noncompaction (LVNC) is a rare cardiomyopathy characterized anatomically by prominent left ventricular trabeculae and deep intratrabecular recesses causing progressive systolic and diastolic dysfunction, conduction abnormalities, and occasionally thromboembolic events."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 13,
  "parents": [
    {
      "id": 3007,
      "label": "intrinsic cardiomyopathy",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6735
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0060036",
          "GARD:0022809"
        ],
        "synonyms": [
          "intrinsic cardiomyopathy",
          "primary cardiomyopathy"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "A cardiomyopathy that is due to abnormalities in heart muscle cells."
      },
      "child_count": 6,
      "reference_id": "MONDO:0000591"
    },
    {
      "id": 6933,
      "label": "familial cardiomyopathy",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6735,
        24272
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:0002945",
          "GARD:0024166",
          "ICD9:425.4",
          "MEDGEN:538845",
          "SCTID:35728003",
          "UMLS:C0264789",
          "icd11.foundation:1018022925"
        ],
        "synonyms": [
          "hereditary cardiomyopathy"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "An instance of cardiomyopathy that is caused by an inherited modification of the individual's genome."
      },
      "child_count": 18,
      "reference_id": "MONDO:0005217"
    },
    {
      "id": 24336,
      "label": "syndromic congenital heart disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4370,
        7116
      ],
      "type_id": 0,
      "properties": {
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "Congenital heart disease with co-occurrence of other extracardiac congenital anomalies, or well characterized genetic conditions."
      },
      "child_count": 16,
      "reference_id": "MONDO:0100614"
    }
  ],
  "children": [
    {
      "id": 12220,
      "label": "dilated cardiomyopathy 1C",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        18829,
        21518,
        24709
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0110423",
          "GARD:0015331",
          "MEDGEN:316944",
          "MESH:C563307",
          "NCIT:C170436",
          "OMIM:601493",
          "UMLS:C1832244"
        ],
        "synonyms": [
          "cardiomyopathy, dilated, 1C, with or without LVNC",
          "cardiomyopathy, hypertrophic, 24",
          "dilated cardiomyopathy type 1C",
          "CMD1C",
          "cardiomyopathy, dilated, 1C, with or without left ventricular noncompaction",
          "cardiomyopathy, familial hypertrophic, 24",
          "left ventricular noncompaction 3"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "A dilated cardiomyopathy that has material basis in mutation in the LDB3 gene on chromosome 10q23.2."
      },
      "child_count": 0,
      "reference_id": "MONDO:0011094"
    },
    {
      "id": 12221,
      "label": "dilated cardiomyopathy 1D",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        18829,
        24709,
        26612
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0110426",
          "GARD:0015332",
          "MEDGEN:316943",
          "MESH:C563306",
          "OMIM:601494",
          "UMLS:C1832243"
        ],
        "synonyms": [
          "CMD1D",
          "TNNT2 familial isolated dilated cardiomyopathy",
          "cardiomyopathy, dilated, type 1D",
          "dilated cardiomyopathy 1D",
          "dilated cardiomyopathy type 1D",
          "familial isolated dilated cardiomyopathy caused by mutation in TNNT2",
          "cardiomyopathy, dilated, 1D",
          "left ventricular noncompaction 6"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "Any familial isolated dilated cardiomyopathy in which the cause of the disease is a mutation in the TNNT2 gene."
      },
      "child_count": 0,
      "reference_id": "MONDO:0011095"
    },
    {
      "id": 12508,
      "label": "left ventricular noncompaction 1",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        18829
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0024797",
          "MEDGEN:349005",
          "OMIM:604169",
          "UMLS:C1858725"
        ],
        "synonyms": [
          "DTNA left ventricular noncompaction",
          "left ventricular noncompaction 1",
          "left ventricular noncompaction 1, with or without congenital heart defects",
          "left ventricular noncompaction caused by mutation in DTNA",
          "left ventricular noncompaction type 1",
          "LVNC1",
          "left ventricular noncompaction 1 with or without congenital heart defects"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "Any left ventricular noncompaction in which the cause of the disease is a mutation in the DTNA gene."
      },
      "child_count": 0,
      "reference_id": "MONDO:0011403"
    },
    {
      "id": 13342,
      "label": "left ventricular noncompaction 2",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        18829
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0015460",
          "MEDGEN:322827",
          "OMIM:609470",
          "UMLS:C1836118"
        ],
        "synonyms": [
          "LVNC2",
          "left ventricular noncompaction 2"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0012285"
    },
    {
      "id": 13784,
      "label": "dilated cardiomyopathy 1Y",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        18829,
        24709
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0110457",
          "GARD:0015530",
          "MEDGEN:437215",
          "MESH:C567507",
          "OMIM:611878",
          "UMLS:C2678476"
        ],
        "synonyms": [
          "CMD1Y",
          "TPM1 familial isolated dilated cardiomyopathy",
          "cardiomyopathy, dilated, type 1Y",
          "dilated cardiomyopathy type 1Y",
          "familial isolated dilated cardiomyopathy caused by mutation in TPM1",
          "cardiomyopathy, dilated, 1Y",
          "left ventricular noncompaction 9"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "Any familial isolated dilated cardiomyopathy in which the cause of the disease is a mutation in the TPM1 gene."
      },
      "child_count": 0,
      "reference_id": "MONDO:0012744"
    },
    {
      "id": 14297,
      "label": "dilated cardiomyopathy 1R",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        18829,
        24709
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0110456",
          "GARD:0015661",
          "MEDGEN:462031",
          "OMIM:613424",
          "UMLS:C3150681"
        ],
        "synonyms": [
          "ACTC1 familial isolated dilated cardiomyopathy",
          "CMD1R",
          "cardiomyopathy, dilated, type 1R",
          "dilated cardiomyopathy type 1R",
          "familial isolated dilated cardiomyopathy caused by mutation in ACTC1",
          "cardiomyopathy, dilated, 1R",
          "left ventricular noncompaction 4"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "Any familial isolated dilated cardiomyopathy in which the cause of the disease is a mutation in the ACTC1 gene."
      },
      "child_count": 0,
      "reference_id": "MONDO:0013261"
    },
    {
      "id": 14298,
      "label": "dilated cardiomyopathy 1S",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        18829,
        24709
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0110454",
          "GARD:0012832",
          "MEDGEN:371831",
          "MESH:C563538",
          "OMIM:613426",
          "UMLS:C1834481"
        ],
        "synonyms": [
          "CMD1S",
          "MYH7 familial isolated dilated cardiomyopathy",
          "cardiomyopathy, dilated, type 1S",
          "dilated cardiomyopathy type 1S",
          "familial isolated dilated cardiomyopathy caused by mutation in MYH7",
          "cardiomyopathy, dilated, 1S",
          "dilated cardiomyopathy-1S",
          "left ventricular noncompaction 5"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "Any familial isolated dilated cardiomyopathy in which the cause of the disease is a mutation in the MYH7 gene."
      },
      "child_count": 0,
      "reference_id": "MONDO:0013262"
    },
    {
      "id": 15052,
      "label": "left ventricular noncompaction 7",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        18829
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0015906",
          "MEDGEN:767410",
          "NCIT:C157266",
          "OMIM:615092",
          "UMLS:C3554496"
        ],
        "synonyms": [
          "MIB1 left ventricular noncompaction",
          "left ventricular noncompaction 7",
          "left ventricular noncompaction caused by mutation in MIB1",
          "left ventricular noncompaction type 7",
          "LVNC7"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "Any left ventricular noncompaction in which the cause of the disease is a mutation in the MIB1 gene."
      },
      "child_count": 0,
      "reference_id": "MONDO:0014042"
    },
    {
      "id": 15159,
      "label": "left ventricular noncompaction 8",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        18829,
        24709
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0081157",
          "GARD:0015952",
          "MEDGEN:815618",
          "OMIM:615373",
          "UMLS:C3809288"
        ],
        "synonyms": [
          "PRDM16 familial isolated dilated cardiomyopathy",
          "familial isolated dilated cardiomyopathy caused by mutation in PRDM16",
          "left ventricular noncompaction 8",
          "left ventricular noncompaction type 8",
          "LVNC8",
          "cardiomyopathy, dilated, 1Ll"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "Any familial isolated dilated cardiomyopathy in which the cause of the disease is a mutation in the PRDM16 gene."
      },
      "child_count": 0,
      "reference_id": "MONDO:0014152"
    },
    {
      "id": 15170,
      "label": "left ventricular noncompaction 10",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        18829,
        24709
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0015956",
          "MEDGEN:811617",
          "OMIM:615396",
          "UMLS:C3715165"
        ],
        "synonyms": [
          "MYBPC3 left ventricular noncompaction",
          "left ventricular noncompaction 10",
          "left ventricular noncompaction caused by mutation in MYBPC3",
          "left ventricular noncompaction type 10",
          "LVNC10",
          "cardiomyopathy, dilated, 1Mm"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "Any left ventricular noncompaction in which the cause of the disease is a mutation in the MYBPC3 gene."
      },
      "child_count": 0,
      "reference_id": "MONDO:0014163"
    },
    {
      "id": 24938,
      "label": "left ventricular noncompaction 9",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        18829
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0026511",
          "MEDGEN:814475",
          "UMLS:C3808145"
        ],
        "synonyms": [
          "LVNC9"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0800346"
    },
    {
      "id": 24942,
      "label": "left ventricular noncompaction 4",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        18829
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0026515",
          "MEDGEN:462032",
          "UMLS:C3150682"
        ],
        "synonyms": [
          "LVNC4"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0800350"
    },
    {
      "id": 24943,
      "label": "left ventricular noncompaction 5",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        18829
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0026516",
          "MEDGEN:462040",
          "UMLS:C3150690"
        ],
        "synonyms": [
          "LVNC5"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0800351"
    }
  ],
  "roots": [
    {
      "id": 3007,
      "label": "intrinsic cardiomyopathy"
    },
    {
      "id": 6933,
      "label": "familial cardiomyopathy"
    },
    {
      "id": 24336,
      "label": "syndromic congenital heart disease"
    }
  ]
}