{
  "id": 18830,
  "label": "hepatocellular adenoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0018902",
  "properties": {
    "xrefs": [
      "DOID:0050868",
      "EFO:0000762",
      "GARD:0018847",
      "ICDO:8170/0",
      "MEDGEN:61655",
      "MESH:D018248",
      "MedDRA:10019827",
      "NCIT:C3758",
      "ONCOTREE:LIAD",
      "Orphanet:54272",
      "UMLS:C0206669",
      "icd11.foundation:1481070735"
    ],
    "synonyms": [
      "HCA",
      "adenoma of liver cells",
      "adenoma of the liver cells",
      "adenoma, hepatocellular, benign",
      "hepatocellular adenoma",
      "liver cell adenoma",
      "LIAD"
    ],
    "categories": [
      {
        "ref": "MONDO:0004335",
        "name": "digestive system disorder"
      },
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "A benign epithelial neoplasm arising from the hepatocytes. Grossly, it appears as a soft, round mass which often contains areas of hemorrhage and necrosis. Morphologically, the neoplastic cells resemble normal hepatocytes and form plates separated by sinusoids. Most patients have a history of contraceptive or anabolic steroids use."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 1,
  "parents": [
    {
      "id": 2884,
      "label": "benign digestive system neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6151,
        6887,
        20434
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050624",
          "MEDGEN:141680",
          "NCIT:C4787",
          "UMLS:C0497538"
        ],
        "synonyms": [
          "alimentary part of gastrointestinal system benign neoplasm",
          "benign GI neoplasm",
          "benign GI system neoplasm",
          "benign GI system tumor",
          "benign GI system tumour",
          "benign GI tumor",
          "benign GI tumour",
          "benign digestive system tumor",
          "benign digestive system tumour",
          "benign gastrointestinal neoplasm",
          "benign gastrointestinal system tumor",
          "benign gastrointestinal system tumour",
          "benign gastrointestinal tumor",
          "benign gastrointestinal tumour",
          "benign neoplasm of digestive system",
          "benign neoplasm of gastrointestinal system",
          "benign neoplasm of the digestive system",
          "benign tumor of GI system",
          "benign tumor of digestive system",
          "benign tumor of gastrointestinal system",
          "benign tumor of the GI system",
          "benign tumor of the digestive system",
          "benign tumor of the gastrointestinal system",
          "benign tumour of GI system",
          "benign tumour of digestive system",
          "benign tumour of gastrointestinal system",
          "benign tumour of the GI system",
          "benign tumour of the digestive system",
          "benign tumour of the gastrointestinal system",
          "gastrointestinal system benign neoplasm"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "A non-metastasizing neoplasm arising from any part of the digestive system."
      },
      "child_count": 30,
      "reference_id": "MONDO:0000385"
    },
    {
      "id": 3032,
      "label": "benign endocrine neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4223,
        6887
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0060089",
          "ICD9:227.8",
          "ICD9:227.9",
          "MEDGEN:87577",
          "NCIT:C4621",
          "SCTID:92085000",
          "UMLS:C0347524"
        ],
        "synonyms": [
          "benign endocrine gland neoplasm",
          "benign endocrine gland tumor",
          "benign endocrine gland tumour",
          "benign endocrine neoplasm",
          "benign endocrine tumor",
          "benign endocrine tumour",
          "benign neoplasm of endocrine gland",
          "benign neoplasm of the endocrine gland",
          "benign tumor of endocrine gland",
          "benign tumor of the endocrine gland",
          "benign tumour of endocrine gland",
          "benign tumour of the endocrine gland",
          "endocrine gland benign neoplasm"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A non-metastasizing, functioning or non-functioning neoplasm that arises from an endocrine organ. Representative examples include thyroid gland follicular adenoma and parathyroid gland adenoma."
      },
      "child_count": 28,
      "reference_id": "MONDO:0000627"
    },
    {
      "id": 6714,
      "label": "adenoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7265
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:657",
          "EFO:0000232",
          "ICDO:8140/0",
          "MEDGEN:125",
          "MESH:D000236",
          "NCIT:C2855",
          "SCTID:443416007",
          "UMLS:C0001430"
        ],
        "synonyms": [
          "adenoma",
          "acinar cell adenoma",
          "acinar cell adenoma (morphologic abnormality)",
          "adenoma, benign"
        ],
        "definition": "A neoplasm arising from the epithelium. It may be encapsulated or non-encapsulated but non-invasive. The neoplastic epithelial cells may or may not display cellular atypia or dysplasia. In the gastrointestinal tract, when dysplasia becomes severe it is sometimes called carcinoma in situ. Representative examples are pituitary gland adenoma, follicular adenoma of the thyroid gland, and adenomas (or adenomatous polyps) of the gastrointestinal tract."
      },
      "child_count": 31,
      "reference_id": "MONDO:0004972"
    },
    {
      "id": 21432,
      "label": "liver and intrahepatic bile duct neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4223,
        4585,
        6878
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:916",
          "MEDGEN:232599",
          "NCIT:C7103",
          "NCIT:C7106",
          "ONCOTREE:LIVER",
          "SCTID:126851005",
          "UMLS:C1333976"
        ],
        "synonyms": [
          "epithelial hepatic and intrahepatic bile duct neoplasm",
          "hepatic and intrahepatic bile duct neoplasm",
          "liver and intrahepatic bile duct epithelial neoplasm",
          "liver and intrahepatic bile duct neoplasm",
          "liver neoplasm",
          "liver neoplasm (disease)",
          "liver tumor",
          "liver tumour",
          "neoplasm of liver",
          "tumor of liver",
          "tumour of liver"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A benign or malignant neoplasm that affects the liver parenchyma or intrahepatic bile ducts. Representative examples of benign neoplasms include hepatocellular adenoma, and bile duct adenoma. Representative examples of malignant neoplasms include hepatocellular carcinoma, intrahepatic cholangiocarcinoma, and lymphoma."
      },
      "child_count": 51,
      "reference_id": "MONDO:0024477"
    },
    {
      "id": 22952,
      "label": "benign epithelial neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6887,
        7265
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "ICDO:8010/0",
          "ICDO:8011/0",
          "MEDGEN:90747",
          "NCIT:C4092",
          "UMLS:C0334232"
        ],
        "synonyms": [
          "benign epithelial neoplasm",
          "benign epithelial tumor",
          "benign epithelial tumour",
          "benign epithelioma",
          "benign neoplasm of epithelium",
          "benign neoplasm of the epithelium",
          "benign tumor of epithelium",
          "benign tumor of the epithelium",
          "benign tumour of epithelium",
          "benign tumour of the epithelium",
          "epithelial neoplasm, benign",
          "epithelioma, benign"
        ],
        "definition": "A neoplasm arising from the epithelial cells. It is characterized by the absence of morphologic features associated with malignancy (severe cytologic atypia, tumor cell necrosis, and high mitotic rate). Benign epithelial neoplasms remain confined to the original site of growth and only rarely metastasize to other anatomic sites."
      },
      "child_count": 50,
      "reference_id": "MONDO:0036976"
    }
  ],
  "children": [
    {
      "id": 9071,
      "label": "hepatic adenomas, familial",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5714,
        18830
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0111366",
          "GARD:0024570",
          "MEDGEN:374515",
          "MESH:C564190",
          "OMIM:142330",
          "UMLS:C1840646"
        ],
        "synonyms": [
          "hepatic adenoma, somatic",
          "hepatic adenomas, familial",
          "liver cell adenomas, familial"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0007718"
    }
  ],
  "roots": [
    {
      "id": 2884,
      "label": "benign digestive system neoplasm"
    },
    {
      "id": 3032,
      "label": "benign endocrine neoplasm"
    },
    {
      "id": 6714,
      "label": "adenoma"
    },
    {
      "id": 21432,
      "label": "liver and intrahepatic bile duct neoplasm"
    },
    {
      "id": 22952,
      "label": "benign epithelial neoplasm"
    }
  ]
}