{
  "id": 18834,
  "label": "follicular lymphoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0018906",
  "properties": {
    "xrefs": [
      "DOID:0050873",
      "GARD:0002356",
      "HGNC:990",
      "ICD10CM:C82",
      "ICD10WHO:C82",
      "ICDO:9690/3",
      "MEDGEN:7417",
      "MESH:D008224",
      "NCIT:C3209",
      "NORD:1983",
      "ONCOTREE:FL",
      "Orphanet:545",
      "SCTID:308121000",
      "UMLS:C0024301",
      "icd11.foundation:797822185"
    ],
    "synonyms": [
      "follicle center lymphoma",
      "follicle centre lymphoma",
      "follicular center cell lymphoma",
      "follicular centre cell lymphoma",
      "follicular non-Hodgkin lymphoma",
      "follicular non-Hodgkin's lymphoma",
      "lymphoma, follicular center cell",
      "lymphoma, follicular centre cell",
      "lymphoma, follicular, malignant",
      "lymphoma, follicular"
    ],
    "categories": [
      {
        "ref": "MONDO:0005046",
        "name": "immune system disorder"
      },
      {
        "ref": "MONDO:0005570",
        "name": "hematologic disorder"
      }
    ],
    "definition": "Follicular lymphoma is a form of non-Hodgkin lymphoma characterized by a proliferation of B cells whose nodular structure of follicular architecture is preserved."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 6694,
      "label": "neoplasm of mature B-cells",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5930
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:706",
          "EFO:0000096",
          "GARD:0024136",
          "ICD9:202.0",
          "MEDGEN:235305",
          "NCIT:C27910",
          "ONCOTREE:MBN",
          "SCTID:269476000",
          "UMLS:C1334633"
        ],
        "synonyms": [
          "mature B-cell lymphocytic neoplasm",
          "mature B-cell neoplasm",
          "mature B-cell neoplasms"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A neoplasm of follicle center B cells which has at least a partial follicular pattern. Follicular lymphomas comprise about 35% of adult non-Hodgkin lymphomas in the U.S. and 22% worldwide. Most patients have widespread disease at diagnosis. Morphologically, follicular lymphomas are classified as Grade 1, Grade 2, and Grade 3, depending on the percentage of the large lymphocytes present. The vast majority of cases (70-95%) express the BCL-2 rearrangement [t(14;18)]. Histological grade correlates with prognosis. Grades 1 and 2 follicular lymphomas are indolent and grade 3 is more aggressive (adapted from WHO, 2001)."
      },
      "child_count": 8,
      "reference_id": "MONDO:0004949"
    },
    {
      "id": 17874,
      "label": "indolent B-cell non-Hodgkin lymphoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        16516
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0021244",
          "MEDGEN:1741600",
          "NCIT:C171299",
          "Orphanet:300842",
          "UMLS:C5419078"
        ],
        "synonyms": [
          "indolent B-cell NHL",
          "B cell lymphoma, indolent",
          "indolent B cell lymphoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ]
      },
      "child_count": 6,
      "reference_id": "MONDO:0017594"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 6694,
      "label": "neoplasm of mature B-cells"
    },
    {
      "id": 17874,
      "label": "indolent B-cell non-Hodgkin lymphoma"
    }
  ]
}