{
  "id": 18835,
  "label": "craniopharyngioma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0018907",
  "properties": {
    "xrefs": [
      "DOID:3840",
      "EFO:1000209",
      "GARD:0010486",
      "ICD9:237.0",
      "ICDO:9350/1",
      "MEDGEN:41339",
      "MESH:D003397",
      "MedDRA:10011318",
      "NANDO:2200091",
      "NCIT:C2964",
      "NORD:1996",
      "Orphanet:54595",
      "SCTID:189179009",
      "UMLS:C0010276"
    ],
    "synonyms": [
      "Rathke pouch neoplasm",
      "Rathke pouch tumor",
      "Rathke pouch tumour",
      "Rathke's pouch neoplasm",
      "Rathke's pouch tumor",
      "Rathke's pouch tumour",
      "craniopharyngioma (WHO grade I)",
      "craniopharyngioma (morphologic abnormality)",
      "craniopharyngioma, benign",
      "neoplasm of Rathke's pouch",
      "tumor of Rathke's pouch",
      "tumour of Rathke's pouch",
      "Adamantinomatous tumor",
      "Adamantinomatous tumour",
      "Dysodontogenic epithelial tumor",
      "Dysodontogenic epithelial tumour",
      "craniopharyngeal duct tumor",
      "craniopharyngeal duct tumour",
      "cystoma"
    ],
    "categories": [
      {
        "ref": "MONDO:0002081",
        "name": "musculoskeletal system disorder"
      },
      {
        "ref": "MONDO:0003900",
        "name": "connective tissue disorder"
      },
      {
        "ref": "MONDO:0005071",
        "name": "nervous system disorder"
      }
    ],
    "definition": "A benign, partly cystic, epithelial tumor of the sellar region, presumably derived from Rathke pouch epithelium. It affects mainly children and young adults. There are two clinicopathological forms: adamantinomatous craniopharyngioma and papillary craniopharyngioma. The most significant factor associated with recurrence is the extent of surgical resection, with lesions greater than 5 cm in diameter carrying a markedly worse prognosis. (Adapted from WHO)"
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 2,
  "parents": [
    {
      "id": 3033,
      "label": "central nervous system organ benign neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3049,
        7694
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0060090",
          "MEDGEN:488882",
          "NCIT:C188049",
          "UMLS:C0347509"
        ],
        "synonyms": [
          "central nervous system benign neoplasm"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A benign neoplasm that involves the central nervous system."
      },
      "child_count": 26,
      "reference_id": "MONDO:0000628"
    },
    {
      "id": 3036,
      "label": "bone benign neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3054,
        18958
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0060094",
          "GARD:0022813",
          "ICD9:213.9",
          "MEDGEN:146337",
          "NCIT:C4880",
          "SCTID:92027006",
          "UMLS:C0684516"
        ],
        "synonyms": [
          "benign bone neoplasm",
          "benign bone tumor",
          "benign bone tumour",
          "benign neoplasm of bone",
          "benign neoplasm of the bone",
          "benign osseous neoplasm",
          "benign osseous tumor",
          "benign osseous tumour",
          "benign tumor of bone",
          "benign tumor of the bone",
          "benign tumour of bone",
          "benign tumour of the bone",
          "bone tissue benign neoplasm"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          }
        ],
        "definition": "A neoplasm that arises from the bone or articular cartilage and does not invade adjacent tissues or metastasize to other anatomic sites."
      },
      "child_count": 38,
      "reference_id": "MONDO:0000631"
    },
    {
      "id": 4600,
      "label": "squamous cell neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7265
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3168",
          "MEDGEN:60219",
          "MESH:D018307",
          "NCIT:C3792",
          "UMLS:C0206720"
        ],
        "synonyms": [
          "epidermoid cell neoplasm",
          "epidermoid cell tumor",
          "epidermoid cell tumour",
          "squamous cell neoplasm",
          "squamous cell tumor",
          "squamous cell tumor (qualifier value)",
          "squamous cell tumour",
          "squamous cell tumour (qualifier value)"
        ],
        "definition": "A neoplasm that is composed of squamous epithelial cells. Squamous cell carcinoma is a representative example."
      },
      "child_count": 7,
      "reference_id": "MONDO:0002532"
    },
    {
      "id": 4759,
      "label": "sella turcica neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4813
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3643",
          "GARD:0023221",
          "MEDGEN:148188",
          "NCIT:C4944",
          "ONCOTREE:SELT",
          "UMLS:C0748616"
        ],
        "synonyms": [
          "neoplasm of sella turcica",
          "neoplasm of the sella turcica",
          "sella turcica neoplasm",
          "sella turcica tumor",
          "sella turcica tumour",
          "sellar neoplasm",
          "sellar tumor",
          "sellar tumour",
          "tumor of the sella turcica",
          "tumour of sella turcica",
          "tumour of the sella turcica",
          "selt"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          }
        ],
        "definition": "A benign or malignant neoplasm that occurs in sella turcica. Representative examples include craniopharyngioma and pituitary gland adenoma."
      },
      "child_count": 4,
      "reference_id": "MONDO:0002720"
    },
    {
      "id": 21213,
      "label": "disorder of facial skeleton",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        21562
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:712533",
          "UMLS:C1290148"
        ],
        "synonyms": [
          "disease of facial skeleton",
          "disease or disorder of facial skeleton",
          "disorder of facial skeleton",
          "facial skeleton disease",
          "facial skeleton disease or disorder",
          "maxillo-facial disease",
          "maxillofacial anomaly"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          }
        ],
        "definition": "A disease that involves the facial skeleton."
      },
      "child_count": 20,
      "reference_id": "MONDO:0023369"
    },
    {
      "id": 22952,
      "label": "benign epithelial neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6887,
        7265
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "ICDO:8010/0",
          "ICDO:8011/0",
          "MEDGEN:90747",
          "NCIT:C4092",
          "UMLS:C0334232"
        ],
        "synonyms": [
          "benign epithelial neoplasm",
          "benign epithelial tumor",
          "benign epithelial tumour",
          "benign epithelioma",
          "benign neoplasm of epithelium",
          "benign neoplasm of the epithelium",
          "benign tumor of epithelium",
          "benign tumor of the epithelium",
          "benign tumour of epithelium",
          "benign tumour of the epithelium",
          "epithelial neoplasm, benign",
          "epithelioma, benign"
        ],
        "definition": "A neoplasm arising from the epithelial cells. It is characterized by the absence of morphologic features associated with malignancy (severe cytologic atypia, tumor cell necrosis, and high mitotic rate). Benign epithelial neoplasms remain confined to the original site of growth and only rarely metastasize to other anatomic sites."
      },
      "child_count": 50,
      "reference_id": "MONDO:0036976"
    }
  ],
  "children": [
    {
      "id": 4815,
      "label": "adamantinous craniopharyngioma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        18835
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3846",
          "GARD:0023245",
          "ICDO:9351/1",
          "MEDGEN:98126",
          "NCIT:C4726",
          "UMLS:C0431129"
        ],
        "synonyms": [
          "adamantinomatous craniopharyngioma",
          "adamantinous Rathke's pouch neoplasm",
          "adamantinous Rathke's pouch tumor",
          "adamantinous Rathke's pouch tumour",
          "adamantinous craniopharyngioma (morphologic abnormality)",
          "adamantinous neoplasm of Rathke's pouch",
          "adamantinous tumor of Rathke's pouch",
          "adamantinous tumour of Rathke's pouch",
          "craniopharyngioma, adamantinomatous"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A craniopharyngioma consisting of broad strands, cords and bridges of a multistratified squamous epithelium with peripheral palisading of nuclei. Diagnostic features include nodules of compact 'wet' keratin and dystrophic calcification. (Adapted from WHO)"
      },
      "child_count": 0,
      "reference_id": "MONDO:0002787"
    },
    {
      "id": 4816,
      "label": "papillary craniopharyngioma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        18835
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3847",
          "GARD:0023246",
          "ICDO:9352/1",
          "MEDGEN:98125",
          "NCIT:C4725",
          "UMLS:C0431128"
        ],
        "synonyms": [
          "craniopharyngioma, papillary",
          "craniopharyngioma, papillary (morphologic abnormality)",
          "papillary Rathke pouch neoplasm",
          "papillary Rathke's pouch neoplasm",
          "papillary Rathke's pouch tumor",
          "papillary Rathke's pouch tumour",
          "papillary craniopharyngioma (morphologic abnormality)",
          "papillary neoplasm of Rathke's pouch",
          "papillary tumor of Rathke's pouch",
          "papillary tumour of Rathke's pouch"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A craniopharyngioma composed of sheets of squamous epithelium which separate to form pseudopapillae. This variant typically lacks nuclear palisading, wet keratin, calcification, and cholesterol deposits. Clinically, endocrine deficiencies are more often associated with papillary craniopharyngioma than with the adamantinomatous type. (Adapted from WHO)"
      },
      "child_count": 0,
      "reference_id": "MONDO:0002788"
    }
  ],
  "roots": [
    {
      "id": 3033,
      "label": "central nervous system organ benign neoplasm"
    },
    {
      "id": 3036,
      "label": "bone benign neoplasm"
    },
    {
      "id": 4600,
      "label": "squamous cell neoplasm"
    },
    {
      "id": 4759,
      "label": "sella turcica neoplasm"
    },
    {
      "id": 21213,
      "label": "disorder of facial skeleton"
    },
    {
      "id": 22952,
      "label": "benign epithelial neoplasm"
    }
  ]
}