{
  "id": 18836,
  "label": "non-Hodgkin lymphoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0018908",
  "properties": {
    "xrefs": [
      "DOID:0060060",
      "EFO:0005952",
      "ICDO:9591/3",
      "MEDGEN:6160",
      "MESH:D008228",
      "MedDRA:10029547",
      "NCIT:C3211",
      "ONCOTREE:NHL",
      "Orphanet:547",
      "UMLS:C0024305"
    ],
    "synonyms": [
      "NHL",
      "non-Hodgkin lymphoma",
      "non-Hodgkin's lymphoma",
      "non-Hodgkin's lymphoma (NHL)",
      "non-Hodgkins lymphoma"
    ],
    "categories": [
      {
        "ref": "MONDO:0005570",
        "name": "hematologic disorder"
      }
    ],
    "definition": "Distinct from Hodgkin lymphoma both morphologically and biologically, non-Hodgkin lymphoma (NHL) is characterized by the absence of Reed-Sternberg cells, can occur at any age, and usually presents as a localized or generalized lymphadenopathy associated with fever and weight loss. The clinical course varies according to the morphologic type. NHL is clinically classified as indolent, aggressive, or having a variable clinical course. NHL can be of B-or T-/NK-cell lineage."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 10,
  "parents": [
    {
      "id": 6792,
      "label": "lymphoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6881,
        16514
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0060058",
          "EFO:0000574",
          "ICD9:200.0",
          "ICD9:200.1",
          "ICD9:202.80",
          "ICDO:9590/3",
          "MEDGEN:44223",
          "MESH:D008223",
          "MedDRA:10025310",
          "NANDO:2100004",
          "NCIT:C3208",
          "ONCOTREE:MLYM",
          "Orphanet:223735",
          "SCTID:118600007",
          "UMLS:C0024299"
        ],
        "synonyms": [
          "lymphoma",
          "lymphoma (Hodgkin and non-Hodgkin)",
          "lymphoma (Hodgkin's and non-Hodgkin's)",
          "lymphoma, malignant",
          "lymphomatous",
          "malignant lymphoma",
          "MLYM"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A malignant (clonal) proliferation of B- lymphocytes or T- lymphocytes which involves the lymph nodes, bone marrow and/or extranodal sites. This category includes Non-Hodgkin lymphomas and Hodgkin lymphomas."
      },
      "child_count": 54,
      "reference_id": "MONDO:0005062"
    }
  ],
  "children": [
    {
      "id": 3163,
      "label": "lymphoblastic lymphoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5444,
        18836
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0080147",
          "GARD:0003329",
          "ICD9:202.80",
          "ICDO:9727/3",
          "MEDGEN:42541",
          "NCIT:C9360",
          "SCTID:109965004",
          "UMLS:C0079748"
        ],
        "synonyms": [
          "lymphoblastic lymphoma",
          "lymphoma, lymphoblastic, malignant",
          "precursor cell lymphoblastic lymphoma",
          "precursor lymphoblastic lymphoma",
          "lymphoma, lymphoblastic"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A lymphoma composed of immature small to medium-sized precursor lymphoid cells (lymphoblasts). It includes the B- and T-cell lymphoblastic lymphoma."
      },
      "child_count": 4,
      "reference_id": "MONDO:0000873"
    },
    {
      "id": 6424,
      "label": "lymphosarcoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        3023,
        18836
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:8675",
          "GARD:0006946",
          "ICD9:200.0",
          "ICD9:200.1",
          "ICD9:200.10",
          "ICD9:200.7",
          "MEDGEN:811370",
          "NCIT:C26919",
          "SCTID:188498009",
          "UMLS:C3714542"
        ],
        "synonyms": [
          "diffuse lymphoma",
          "lymphosarcoma",
          "malignant lymphoma (category)"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "An antiquated term that refers to a non-Hodgkin lymphoma composed of small and medium sized lymphocytes."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004638"
    },
    {
      "id": 6710,
      "label": "acute lymphoblastic leukemia",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5444,
        6890,
        7079,
        11789,
        18836
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:9952",
          "EFO:0000220",
          "GARD:0000522",
          "HP:0006721",
          "ICD10CM:C91.0",
          "ICD9:204",
          "ICD9:204.0",
          "ICD9:204.00",
          "ICD9:204.9",
          "ICDO:9835/3",
          "MEDGEN:7317",
          "NCIT:C3167",
          "Orphanet:513",
          "SCTID:91857003",
          "UMLS:C0023449"
        ],
        "synonyms": [
          "lymphoblastic leukaemia",
          "lymphoblastic leukemia",
          "ALL",
          "ALL - acute lymphocytic leukaemia",
          "ALL - acute lymphocytic leukemia",
          "acute lymphoblastic leukaemia (ALL)",
          "acute lymphoblastic leukaemia (disease)",
          "acute lymphoblastic leukemia",
          "acute lymphoblastic leukemia (ALL)",
          "acute lymphoblastic leukemia (disease)",
          "acute lymphoblastic leukemia/lymphoma",
          "acute lymphocytic leukaemia",
          "acute lymphocytic leukemia",
          "acute lymphocytic leukemias",
          "acute lymphogenous leukaemia",
          "acute lymphogenous leukemia",
          "acute lymphoid leukaemia",
          "acute lymphoid leukemia",
          "leukemia, lymphoblastic, malignant",
          "lymphoblastic leukemia, acute",
          "precursor Lymphoblasic leukaemia",
          "precursor Lymphoblasic leukemia",
          "precursor cell lymphoblastic leukaemia",
          "precursor cell lymphoblastic leukemia",
          "precursor lymphoblastic leukaemia",
          "precursor lymphoblastic leukemia"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "Leukemia with an acute onset, characterized by the presence of lymphoblasts in the bone marrow and the peripheral blood. It includes the acute B lymphoblastic leukemia and acute T lymphoblastic leukemia."
      },
      "child_count": 60,
      "reference_id": "MONDO:0004967"
    },
    {
      "id": 12608,
      "label": "lymphoma, non-Hodgkin, familial",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        18836
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0024804",
          "ICD9:202.80",
          "MEDGEN:1648388",
          "OMIM:605027",
          "SCTID:118601006",
          "UMLS:C4721532"
        ],
        "synonyms": [
          "lymphoma, follicular, somatic",
          "lymphoma, non-Hodgkin",
          "lymphoma, non-Hodgkin, familial",
          "lymphoma, non-Hodgkin, somatic",
          "non-Hodgkin lymphoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0011508"
    },
    {
      "id": 16516,
      "label": "B-cell non-Hodgkin lymphoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5930,
        18836
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:1001938",
          "GARD:0020132",
          "NANDO:2200020",
          "NCIT:C3457",
          "Orphanet:171915"
        ],
        "synonyms": [
          "B-cell NHL",
          "B-cell lymphoma",
          "B-cell non Hodgkin's lymphoma",
          "B-cell non-Hodgkin lymphoma",
          "B-cell non-Hodgkin's lymphoma",
          "lymphomas non-Hodgkin's B-cell",
          "non-Hodgkin's B-cell lymphoma",
          "non-Hodgkin's lymphoma B-cell"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "The most common type of non-Hodgkin lymphoma. It includes the most frequently seen morphologic variants which are: diffuse large B-cell lymphoma, follicular lymphoma, small lymphocytic lymphoma and marginal zone B-cell lymphoma. -- 2003"
      },
      "child_count": 10,
      "reference_id": "MONDO:0015759"
    },
    {
      "id": 16517,
      "label": "T-cell non-Hodgkin lymphoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        18836
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0081312",
          "GARD:0020133",
          "ICD9:202.70",
          "MEDGEN:86957",
          "MESH:D016399",
          "MedDRA:10042971",
          "NCIT:C3466",
          "Orphanet:171918",
          "SCTID:109978004",
          "UMLS:C0079772"
        ],
        "synonyms": [
          "T cell lymphoma",
          "T-cell NHL",
          "T-cell and NK-cell non-Hodgkin lymphoma",
          "T-cell and NK-cell non-Hodgkin's lymphoma",
          "T-cell lymphoma",
          "T-cell non-Hodgkin lymphoma",
          "T-cell non-Hodgkin's lymphoma",
          "non-Hodgkin's T-cell lymphoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A non-Hodgkin lymphoma of T-cell lineage. It includes the T lymphoblastic lymphoma and the mature T- and NK-cell lymphomas. -- 2003"
      },
      "child_count": 9,
      "reference_id": "MONDO:0015760"
    },
    {
      "id": 20058,
      "label": "lung non-Hodgkin lymphoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5840,
        18836
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0025193",
          "MEDGEN:235267",
          "NCIT:C5684",
          "UMLS:C1334453"
        ],
        "synonyms": [
          "lung non-Hodgkin lymphoma",
          "lung non-Hodgkin's lymphoma",
          "non-Hodgkin lymphoma of lung",
          "primary lung non-Hodgkin's lymphoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A rare non-Hodgkin lymphoma that arises in and is confined to the lung at the time of diagnosis. Representative examples include bronchial mucosa-associated lymphoid tissue lymphoma and diffuse large B-cell lymphoma."
      },
      "child_count": 2,
      "reference_id": "MONDO:0020644"
    },
    {
      "id": 20060,
      "label": "ocular adnexal lymphoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        2924,
        7231,
        18836
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0025195",
          "MEDGEN:453939",
          "NCIT:C88145",
          "UMLS:C2981712"
        ],
        "synonyms": [
          "OAL",
          "non-Hodgkin lymphoma of ocular adnexa",
          "ocular adnexa non-Hodgkin lymphoma",
          "ocular adnexal lymphoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002022",
            "name": "disorder of orbital region"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A non-Hodgkin lymphoma arising from the conjunctiva, lacrimal gland, lacrimal drainage apparatus, eyelids, or other orbital tissues around the eye. The vast majority of cases are extranodal marginal zone lymphomas of mucosa-associated lymphoid tissue, however, other histologic types of lymphomas can originate from ocular adnexal tissues, including rare cases of NK/T-cell lymphomas of nasal type."
      },
      "child_count": 0,
      "reference_id": "MONDO:0020646"
    },
    {
      "id": 20808,
      "label": "large-cell immunoblastic lymphoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        18836
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0008219",
          "MEDGEN:86955",
          "MESH:D016400",
          "UMLS:C0079746"
        ],
        "synonyms": [
          "Diffuse Immunoblastic Lymphosarcoma",
          "Diffuse Immunoblastic Lymphosarcomas",
          "Diffuse non-Hodgkin lymphoma, immunoblastic",
          "Diffuse non-Hodgkin's immunoblastic (diffuse) lymphoma",
          "Diffuse non-Hodgkin's lymphoma, immunoblastic",
          "Diffuse non-Hodgkin's lymphoma, immunoblastic (clinical)",
          "IMMUNOBLASTIC LARGE LYMPHOMA",
          "Immunoblastic Large Cell Lymphoma",
          "Immunoblastic Large-Cell Lymphoma",
          "Immunoblastic Large-Cell Lymphomas",
          "Immunoblastic Lymphoma",
          "Immunoblastic Lymphoma, Large-Cell",
          "Immunoblastic Lymphomas, Large-Cell",
          "Immunoblastic Lymphosarcoma, Diffuse",
          "Immunoblastic Lymphosarcomas, Diffuse",
          "Immunoblastic Sarcoma",
          "Immunoblastic Sarcomas",
          "Immunoblastic malignant lymphoma - large cell",
          "Immunoblastoma",
          "Immunoblastomas",
          "LARGE IMMUNOBLASTIC LYMPHOMA",
          "LYMPHOMA IMMUNOBLASTIC LARGE",
          "LYMPHOMA LARGE IMMUNOBLASTIC",
          "Large Cell Immunoblastic Lymphoma",
          "Large cell immunoblastic lymphoma",
          "Large-Cell Immunoblastic Lymphoma",
          "Large-Cell Immunoblastic Lymphomas",
          "Large-Cell Lymphoma, Immunoblastic",
          "Large-Cell Lymphomas, Immunoblastic",
          "Lymphoma, Immunoblastic Large-Cell",
          "Lymphoma, Immunoblastic, Large Cell",
          "Lymphoma, Immunoblastic, Large-Cell",
          "Lymphoma, Large Cell, Immunoblastic",
          "Lymphoma, Large-Cell Immunoblastic",
          "Lymphoma, Large-Cell, Immunoblastic",
          "Lymphoma, immunoblastic, high grade",
          "Lymphomas, Immunoblastic Large-Cell",
          "Lymphomas, Large-Cell Immunoblastic",
          "Lymphosarcoma, Diffuse Immunoblastic",
          "Lymphosarcomas, Diffuse Immunoblastic",
          "Malignant lymphoma - immunoblastic",
          "Sarcoma, Immunoblastic",
          "Sarcomas, Immunoblastic"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "Malignant lymphoma characterized by the presence of immunoblasts with uniformly round-to-oval nuclei, one or more prominent nucleoli, and abundant cytoplasm. This class may be subdivided into plasmacytoid and clear-cell types based on cytoplasmic characteristics. A third category, pleomorphous, may be analogous to some of the peripheral T-cell lymphomas (LYMPHOMA, T-CELL, PERIPHERAL) recorded in both the United States and Japan."
      },
      "child_count": 0,
      "reference_id": "MONDO:0022037"
    },
    {
      "id": 23066,
      "label": "gastric non-hodgkin lymphoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3314,
        18836
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0000089",
          "MEDGEN:232549",
          "NCIT:C27235",
          "SCTID:448709005",
          "UMLS:C1333784"
        ],
        "synonyms": [
          "gastric non-Hodgkin lymphoma",
          "gastric non-Hodgkin's lymphoma",
          "non-Hodgkin lymphoma of stomach",
          "non-Hodgkin's lymphoma of stomach",
          "non-Hodgkin's lymphoma of the stomach",
          "primary gastric non-Hodgkin's lymphoma",
          "stomach non-Hodgkin lymphoma",
          "lymphoma, gastric non Hodgkins type",
          "non-Hodgkins gastric lymphoma",
          "stomach lymphoma, non-Hodgkins type"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "An extranodal non-Hodgkin lymphoma that arises from the stomach with the bulk of the mass located in the stomach. The vast majority of cases are diffuse large B-cell lymphomas and B-cell lymphomas of the mucosa-associated lymphoid tissue."
      },
      "child_count": 4,
      "reference_id": "MONDO:0042493"
    }
  ],
  "roots": [
    {
      "id": 6792,
      "label": "lymphoma"
    }
  ]
}