{
  "id": 18839,
  "label": "Cushing syndrome",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0018912",
  "properties": {
    "xrefs": [
      "EFO:0003099",
      "GARD:0006224",
      "ICD10CM:E24",
      "ICD10WHO:E24",
      "ICD9:255.0",
      "MEDGEN:3681",
      "MESH:D003480",
      "MedDRA:10011652",
      "MedDRA:10020562",
      "MedDRA:10020564",
      "MedDRA:10020610",
      "NCIT:C2969",
      "Orphanet:553",
      "UMLS:C0010481",
      "icd11.foundation:1654321425"
    ],
    "synonyms": [
      "hypercortisolism",
      "Cushing syndrome",
      "Cushing's syndrome",
      "cortisol Excess",
      "hyperadrenocorticism",
      "pituitary basophilism",
      "suprarenogenic syndrome",
      "adrenal hyperfunction resulting from pituitary ACTH excess",
      "ectopic adrenocorticotropic hormone syndrome",
      "nodular primary adrenocortical dysplasia"
    ],
    "categories": [
      {
        "ref": "MONDO:0002254",
        "name": "syndromic disease"
      }
    ],
    "definition": "Cushing's syndrome (CS) encompasses a group of hormonal disorders caused by prolonged and high exposure levels to glucocorticoids that can be of either endogenous (adrenal cortex production) or exogenous (iatrogenic) origin."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 2,
  "parents": [
    {
      "id": 4370,
      "label": "syndromic disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        29379
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:225",
          "MEDGEN:11688",
          "MESH:D013577",
          "NCIT:C28193",
          "OGMS:0000086",
          "UMLS:C0039082"
        ],
        "synonyms": [
          "cluster, symptom",
          "clusters, symptom",
          "symptom cluster",
          "symptom clusters",
          "syndrome",
          "syndrome associated with disease or disorder",
          "syndromes",
          "syndromic disease",
          "syndromic disease or disorder"
        ],
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          }
        ],
        "definition": "A group of signs, symptoms, and clinicopathological characteristics that may or may not have a genetic basis and collectively define an abnormal condition."
      },
      "child_count": 1182,
      "reference_id": "MONDO:0002254"
    }
  ],
  "children": [
    {
      "id": 25672,
      "label": "endogenous Cushing syndrome",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7151,
        18839
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0026827",
          "MEDGEN:1727013",
          "Orphanet:641613",
          "UMLS:C5419158"
        ],
        "synonyms": [
          "endogenous CS"
        ],
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "Any Cushing syndrome caused by body's prolonged overproduction of cortisol that can be dependent on or independent of adrenocorticotropic hormone (ACTH)."
      },
      "child_count": 4,
      "reference_id": "MONDO:0957431"
    },
    {
      "id": 29308,
      "label": "exogenous Cushing syndrome",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        18839
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0028155",
          "MEDGEN:543520",
          "UMLS:C0271725"
        ],
        "synonyms": [
          "exogenous Cushing’s syndrome",
          "iatrogenic Cushing's syndrome"
        ],
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          }
        ],
        "definition": "A form of Cushing syndrome caused by prolonged exposure or excessive use of cortisteroids, usually from medications taken to treat other conditions."
      },
      "child_count": 0,
      "reference_id": "MONDO:1060126"
    }
  ],
  "roots": [
    {
      "id": 4370,
      "label": "syndromic disease"
    }
  ]
}