{
  "id": 18842,
  "label": "carcinoma of gallbladder and extrahepatic biliary tract",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0018918",
  "properties": {
    "xrefs": [
      "GARD:0018850",
      "MEDGEN:1797980",
      "MedDRA:10007426",
      "Orphanet:56044",
      "UMLS:C5566557"
    ],
    "synonyms": [
      "carcinoma of gallbladder and EBT"
    ],
    "categories": [
      {
        "ref": "MONDO:0004335",
        "name": "digestive system disorder"
      },
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "Carcinoma of the gallbladder (GBC) is the most common and aggressive form of biliary tract cancer (BTC) usually arising in the fundus of the gallbladder, rapidly metastasizing to lymph nodes and distant sites."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 2,
  "parents": [
    {
      "id": 20541,
      "label": "extrahepatic bile duct neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        20714
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:91056",
          "NCIT:C4441",
          "SCTID:126855001",
          "UMLS:C0345913"
        ],
        "synonyms": [
          "extrahepatic bile duct neoplasm",
          "extrahepatic bile duct neoplasm (disease)",
          "extrahepatic bile duct tumor",
          "extrahepatic bile duct tumour",
          "neoplasm of extrahepatic bile duct",
          "neoplasm of the extrahepatic bile duct",
          "tumor of extrahepatic bile duct",
          "tumor of the extrahepatic bile duct",
          "tumour of extrahepatic bile duct",
          "tumour of the extrahepatic bile duct"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A benign or malignant neoplasm that affects the extrahepatic bile ducts. Representative examples include adenoma and adenocarcinoma."
      },
      "child_count": 7,
      "reference_id": "MONDO:0021385"
    }
  ],
  "children": [
    {
      "id": 18555,
      "label": "adenocarcinoma of gallbladder and extrahepatic biliary tract",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4714,
        18842
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0021791",
          "MEDGEN:1633887",
          "Orphanet:424991",
          "SCTID:765741003",
          "UMLS:C4707555"
        ],
        "synonyms": [
          "adenocarcinoma of gallbladder and EBT",
          "adenocarcinoma of the gallbladder and EBT",
          "adenocarcinoma of the gallbladder and extrahepatic biliary tract"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "Adenocarcinoma of the gallbladder and extrahepatic biliary tract is a rare epithelial carcinoma, arising either in the gallbladder itself or from the epithelium lining the extrahepatic biliary tree, cystic duct and/or peribiliary gland, characterized by nonspecific symptoms, such as abdominal pain, jaundice and vomiting and sometimes mimicking benign biliary diseases. Chronic biliary epithelial inflammation (e.g. primary sclerosing cholangitis, cholelithiasis, choledocholithiasis, liver fluke infestation) is a major risk factor."
      },
      "child_count": 4,
      "reference_id": "MONDO:0018536"
    },
    {
      "id": 18556,
      "label": "squamous cell carcinoma of gallbladder and extrahepatic biliary tract",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7758,
        18842
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0021792",
          "MEDGEN:1635098",
          "Orphanet:424996",
          "SCTID:766978002",
          "UMLS:C4707898"
        ],
        "synonyms": [
          "squamous cell carcinoma of gallblader and EBT"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "Squamous cell carcinoma of the gallbladder and extrahepatic biliary tract is a rare hepatic and biliary tract tumor, arising either in the gallbladder itself or in the epithelium lining the extrahepatic biliary tree, the cystic duct and peribiliary glands. It is characterized by a substantial keratinization with abundant keratohyalin pearls and central deposition of dense keratin material within infiltrative nests and locally aggressive nature. In the early stages of the disease symptoms are vague and nonspecific (abdominal pain, jaundice and vomiting). In the advanced stages it may present with a bulky tumor and symptoms of adjacent organ involvement."
      },
      "child_count": 0,
      "reference_id": "MONDO:0018537"
    }
  ],
  "roots": [
    {
      "id": 20541,
      "label": "extrahepatic bile duct neoplasm"
    }
  ]
}