{
  "id": 18857,
  "label": "hairy cell leukemia",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0018935",
  "properties": {
    "xrefs": [
      "DOID:285",
      "EFO:1000956",
      "GARD:0006560",
      "ICD10CM:C91.4",
      "ICD9:202.4",
      "ICDO:9940/3",
      "MEDGEN:9727",
      "MESH:D007943",
      "MedDRA:10019053",
      "MedDRA:10019055",
      "NCIT:C7402",
      "NORD:1213",
      "ONCOTREE:HCL",
      "Orphanet:58017",
      "SCTID:118613001",
      "UMLS:C0023443",
      "icd11.foundation:82152208"
    ],
    "synonyms": [
      "HCL",
      "HCL-C",
      "hairy cell leukemia",
      "leukemic reticuloendotheliosis",
      "classic hairy cell leukaemia",
      "classic hairy cell leukemia"
    ],
    "categories": [
      {
        "ref": "MONDO:0005046",
        "name": "immune system disorder"
      },
      {
        "ref": "MONDO:0005570",
        "name": "hematologic disorder"
      }
    ],
    "definition": "Hairy cell leukemia (HCL) is a rare type of leukemia in which abnormal B-lymphocytes are present in the bone marrow, spleen and peripheral blood. It is a slowly progressive chronic lymphocytic leukemia (CLL). The name comes from the abnormally shaped lymphocytes with hair-like projections."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 4,
  "parents": [
    {
      "id": 6693,
      "label": "B-cell chronic lymphocytic leukemia",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3274,
        6694,
        6710,
        17874
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1040",
          "EFO:0000095",
          "GARD:0006104",
          "ICD10CM:C91.1",
          "ICD9:204.1",
          "MEDGEN:44120",
          "MESH:D015451",
          "MedDRA:10008958",
          "NCIT:C3163",
          "NORD:971",
          "OMIM:151400",
          "Orphanet:67038",
          "UMLS:C0023434"
        ],
        "synonyms": [
          "B cell CLL",
          "B cell chronic lymphocytic leukaemia",
          "B cell chronic lymphocytic leukemia",
          "B cell lymphocytic leukaemia",
          "B cell lymphocytic leukemia",
          "B-CLL",
          "B-cell CLL",
          "B-cell chronic lymphocytic leukemia",
          "B-cell chronic lymphogenous leukaemia",
          "B-cell chronic lymphogenous leukemia",
          "B-cell chronic lymphoid leukaemia",
          "B-cell chronic lymphoid leukemia",
          "B-cell lymphocytic leukaemia",
          "B-cell lymphocytic leukemia",
          "BCLL",
          "CLL",
          "Chronic Lymphocytic Leukemia",
          "chronic B-cell lymphocytic leukaemia",
          "chronic B-cell lymphocytic leukemia",
          "chronic lymphatic leukemia",
          "chronic lymphocytic leukaemia (CLL)",
          "chronic lymphocytic leukemia",
          "chronic lymphocytic leukemia (CLL)",
          "chronic lymphogenous leukaemia",
          "chronic lymphogenous leukemia",
          "hematopoeitic - chronic lymphocytic leukaemia (CLL)",
          "hematopoeitic - chronic lymphocytic leukemia (CLL)",
          "lymphoplasmacytic leukemia",
          "leukemia, chronic LYMPHOCYTIC",
          "leukemia, chronic lymphatic",
          "leukemia, lymphocytic, chronic",
          "small lymphocytic lymphoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "B-cell chronic lymphocytic leukemia (B-CLL) is a type of B-cell non-Hodgkin lymphoma, and the most common form of leukemia in Western countries, affecting elderly adults (mean age of 67 and 72 years) with a slight male predominance (1.7:1), and characterized by a highly variable clinical presentation that can include asymptomatic disease or non-specific B-symptoms such as unintentional weight loss, severe fatigue, fever (without evidence of infection), and night sweats as well as cervical lymphadenopathy, splenomegaly and frequent infections. Some patients can also develop autoimmune complications such as autoimmune hemolytic anemia or immune thrombocytopenia. The clinical course is extremely heterogeneous with survival ranging from a few months to several decades."
      },
      "child_count": 8,
      "reference_id": "MONDO:0004948"
    }
  ],
  "children": [
    {
      "id": 3804,
      "label": "intrapelvic lymph node leukemic reticuloendotheliosis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        3334,
        18857
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:12972",
          "GARD:0022973",
          "ICD9:202.46",
          "MEDGEN:509467",
          "SCTID:93145002",
          "UMLS:C0153831"
        ],
        "synonyms": [
          "leukemic reticuloendotheliosis involving intrapelvic lymph nodes"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0001607"
    },
    {
      "id": 5938,
      "label": "splenic manifestation of hairy cell leukemia",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5941,
        6479,
        18857
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:709",
          "GARD:0023825",
          "ICD9:202.47",
          "MEDGEN:234812",
          "NCIT:C7301",
          "SCTID:93151007",
          "UMLS:C1336064"
        ],
        "synonyms": [
          "spleen hairy cell leukaemia",
          "spleen hairy cell leukemia",
          "splenic manifestation of hairy cell leukemia"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A hairy cell leukemia that involves the spleen."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004104"
    },
    {
      "id": 5944,
      "label": "refractory hairy cell leukemia",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5945,
        18857
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:711",
          "GARD:0023830",
          "MEDGEN:1639342",
          "NCIT:C8030",
          "UMLS:C4551546"
        ],
        "synonyms": [
          "hairy cell leukemia, refractory",
          "refractory hairy cell leukemia"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "Hairy cell leukemia that is resistant to treatment."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004110"
    },
    {
      "id": 17880,
      "label": "hairy cell leukemia variant",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        18857
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:713",
          "GARD:0021249",
          "ICDO:9591/3",
          "MEDGEN:91160",
          "MedDRA:10019054",
          "NCIT:C7401",
          "Orphanet:300878",
          "SCTID:277568007",
          "UMLS:C0349633"
        ],
        "synonyms": [
          "HCL-V",
          "HCL-v",
          "hairy cell leukemia variant",
          "leukemic reticuloendotheliosis variant",
          "prolymphocytic variant of HCL",
          "prolymphocytic variant of hairy cell leukaemia",
          "prolymphocytic variant of hairy cell leukemia"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "Hairy Cell Leukemia variant (HCL-V) is defined as a rare and indolent form of small, mature, B-cell leukemia characterized by splenomegaly, an elevated white blood cell (WBC) count and hyper-cellular bone marrow. HCL-V is more aggressive and resistant to therapy than classical HCL (HCL-C)."
      },
      "child_count": 0,
      "reference_id": "MONDO:0017600"
    }
  ],
  "roots": [
    {
      "id": 6693,
      "label": "B-cell chronic lymphocytic leukemia"
    }
  ]
}