{
  "id": 18866,
  "label": "gestational trophoblastic neoplasm",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0018944",
  "properties": {
    "xrefs": [
      "DOID:3590",
      "GARD:0006498",
      "ICD9:630",
      "MEDGEN:210107",
      "MedDRA:10061988",
      "NCIT:C4699",
      "Orphanet:59305",
      "SCTID:609519004",
      "UMLS:C1135868",
      "icd11.foundation:1972855304"
    ],
    "synonyms": [
      "gestational trophoblastic disease",
      "GTN",
      "GTT",
      "gestational trophoblastic tumor",
      "gestational trophoblastic tumour",
      "hydatidiform mole",
      "molar pregnancy"
    ],
    "categories": [
      {
        "ref": "MONDO:0005039",
        "name": "reproductive system disorder"
      }
    ],
    "definition": "A diverse group of pregnancy-related tumors characterized by excessive proliferation of trophoblasts. Representative examples include hydatidiform mole, gestational choriocarcinoma, and placental site trophoblastic tumor."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 6,
  "parents": [
    {
      "id": 4886,
      "label": "trophoblastic neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6798
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4085",
          "MEDGEN:21708",
          "MESH:D014328",
          "NCIT:C3422",
          "UMLS:C0041182"
        ],
        "synonyms": [
          "neoplasm of trophoblast",
          "trophoblast neoplasm",
          "trophoblast neoplasm (disease)",
          "trophoblast tumor",
          "trophoblast tumour",
          "trophoblastic neoplasm",
          "trophoblastic neoplasm (morphologic abnormality)",
          "trophoblastic neoplasm NOS (morphologic abnormality)",
          "trophoblastic neoplasms",
          "trophoblastic tumor",
          "trophoblastic tumor (qualifier value)",
          "trophoblastic tumour",
          "trophoblastic tumour (qualifier value)",
          "tumor of trophoblast",
          "tumour of trophoblast"
        ],
        "definition": "A gestational or non-gestational neoplasm composed of neoplastic trophoblastic cells. Representative examples include hydatidiform mole and choriocarcinoma."
      },
      "child_count": 4,
      "reference_id": "MONDO:0002872"
    },
    {
      "id": 20384,
      "label": "female reproductive system neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4379,
        7638
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:9004",
          "MESH:D005833",
          "NCIT:C3053",
          "UMLS:C0017416"
        ],
        "synonyms": [
          "female reproductive organ neoplasm (disease)",
          "female reproductive organ tumor",
          "female reproductive organ tumour",
          "female reproductive system neoplasm",
          "female reproductive system neoplasm (disease)",
          "female reproductive system tumor",
          "female reproductive system tumour",
          "gynecologic neoplasm",
          "gynecologic tumor",
          "gynecologic tumour",
          "neoplasm of female reproductive organ",
          "neoplasm of female reproductive system",
          "neoplasm of the female reproductive system",
          "tumor of female reproductive system",
          "tumor of the female reproductive system",
          "tumour of female reproductive system",
          "tumour of the female reproductive system"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A benign, precancerous, or malignant neoplasm that affects the female reproductive system. Representative examples include uterine corpus leiomyoma, endocervical polyp, ovarian carcinoma, cervical carcinoma, and endometrial carcinoma."
      },
      "child_count": 22,
      "reference_id": "MONDO:0021148"
    },
    {
      "id": 21520,
      "label": "pregnancy disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        24401
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:0009682",
          "MEDGEN:56248",
          "MESH:D011248",
          "NCIT:C35169",
          "SCTID:173300003",
          "UMLS:C0151864"
        ],
        "synonyms": [
          "complication of pregnancy or childbirth",
          "disorder of pregnancy",
          "disorder of pregnancy, childbirth, or puerperium",
          "pregnancy disease",
          "pregnancy disorder",
          "Complications, pregnancy",
          "complication, pregnancy",
          "pregnancy complication"
        ],
        "definition": "A disorder that is related to pregnancy. Representative examples include ectopic pregnancy, toxemia of pregnancy, and gestational trophoblastic tumor."
      },
      "child_count": 29,
      "reference_id": "MONDO:0024575"
    }
  ],
  "children": [
    {
      "id": 10514,
      "label": "hydatidiform mole, recurrent, 1",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        17226,
        18866
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0018365",
          "MEDGEN:483038",
          "OMIM:231090",
          "UMLS:C3463897"
        ],
        "synonyms": [
          "NLRP7 complete hydatidiform mole",
          "complete hydatidiform mole caused by mutation in NLRP7",
          "hydatidiform Mole, recurrent, type 1",
          "hydatidiform mole, recurrent, 1",
          "HYDM1",
          "gestational trophoblastic disease",
          "hydatidiform MOLE, recurrent, 1",
          "hydatidiform Mole, complete",
          "hydatidiform mole"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "Any complete hydatidiform mole in which the cause of the disease is a mutation in the NLRP7 gene."
      },
      "child_count": 0,
      "reference_id": "MONDO:0009273"
    },
    {
      "id": 14694,
      "label": "hydatidiform mole, recurrent, 2",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        17226,
        18866
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0018366",
          "MEDGEN:481982",
          "OMIM:614293",
          "UMLS:C3280352"
        ],
        "synonyms": [
          "KHDC3L complete hydatidiform mole",
          "complete hydatidiform mole caused by mutation in KHDC3L",
          "hydatidiform Mole, recurrent, type 2",
          "hydatidiform mole, recurrent, 2",
          "HYDM2",
          "hydatidiform MOLE, recurrent, 2",
          "hydatidiform Mole, complete"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "Any complete hydatidiform mole in which the cause of the disease is a mutation in the KHDC3L gene."
      },
      "child_count": 0,
      "reference_id": "MONDO:0013671"
    },
    {
      "id": 17228,
      "label": "epithelioid trophoblastic tumor",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        18866
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3593",
          "GARD:0020750",
          "ICDO:9105/3",
          "MEDGEN:266107",
          "NCIT:C6900",
          "ONCOTREE:ETT",
          "Orphanet:254698",
          "SCTID:609515005",
          "UMLS:C1266159"
        ],
        "synonyms": [
          "epithelioid trophoblastic tumor",
          "ETT"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "An epithelioid trophoblastic tumor is an extremely rare gestational trophoblastic tumor (GTT) which generally occurs several years after pregnancy."
      },
      "child_count": 0,
      "reference_id": "MONDO:0016787"
    },
    {
      "id": 19992,
      "label": "invasive hydatidiform mole",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7798,
        18866
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0019711",
          "ICDO:9100/1",
          "MEDGEN:3055",
          "MESH:D002820",
          "NCIT:C6985",
          "ONCOTREE:IHM",
          "Orphanet:99925",
          "SCTID:416669000",
          "UMLS:C0008493"
        ],
        "synonyms": [
          "chorioadenoma",
          "chorioadenoma Destruens",
          "chorioadenoma destruens",
          "invasive Mole",
          "invasive gestational trophoblastic neoplasm",
          "invasive hydatidiform Mole",
          "invasive hydatidiform mole",
          "IHM"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A complete hydatidiform mole or very rarely a partial mole that invades the myometrium."
      },
      "child_count": 0,
      "reference_id": "MONDO:0020549"
    },
    {
      "id": 19993,
      "label": "gestational choriocarcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3637,
        5475,
        6924,
        18866
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2025",
          "GARD:0019712",
          "ICD9:181",
          "MEDGEN:138102",
          "NCIT:C4646",
          "Orphanet:99926",
          "SCTID:417570003",
          "UMLS:C0349557",
          "icd11.foundation:2136066651"
        ],
        "synonyms": [
          "gestational choriocarcinoma",
          "gestational choriocarcinoma (morphologic abnormality)"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "Gestational choriocarcinoma is a gestational trophoblastic tumor (GTT) occurring secondary to pregnancy (ectopic or normal), miscarriage, voluntary termination of pregnancy (VTP) or a hydatidiform mole."
      },
      "child_count": 16,
      "reference_id": "MONDO:0020550"
    },
    {
      "id": 19994,
      "label": "placental site trophoblastic tumor",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6924,
        18866
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3596",
          "EFO:1001111",
          "GARD:0007403",
          "ICDO:9104/1",
          "MEDGEN:104914",
          "MESH:D018245",
          "NCIT:C3757",
          "ONCOTREE:PSTT",
          "Orphanet:99928",
          "SCTID:237252008",
          "UMLS:C0206666"
        ],
        "synonyms": [
          "PSST",
          "placental site gestational trophoblastic tumor",
          "placental site gestational trophoblastic tumour",
          "placental site trophoblastic tumor",
          "placental site trophoblastic tumor (morphologic abnormality)",
          "placental site trophoblastic tumour (morphologic abnormality)",
          "placental-site GTT",
          "placental-site gestational trophoblastic neoplasm",
          "placental-site gestational trophoblastic tumor",
          "placental-site gestational trophoblastic tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "Placental site trophoblastic tumor is a rare gestational trophoblastic tumor (GTT) which develops from the placental implantation site and always occurs following pregnancy, voluntary termination of pregnancy (VTP) or miscarriage."
      },
      "child_count": 0,
      "reference_id": "MONDO:0020552"
    }
  ],
  "roots": [
    {
      "id": 4886,
      "label": "trophoblastic neoplasm"
    },
    {
      "id": 20384,
      "label": "female reproductive system neoplasm"
    },
    {
      "id": 21520,
      "label": "pregnancy disorder"
    }
  ]
}