{
  "id": 18875,
  "label": "parietal foramina",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0018953",
  "properties": {
    "xrefs": [
      "DOID:0060285",
      "GARD:0016662",
      "HP:0002697",
      "MESH:C566826",
      "OMIMPS:168500",
      "Orphanet:60015",
      "SCTID:718099006",
      "icd11.foundation:905361904"
    ],
    "synonyms": [
      "catlin marks",
      "enlarged parietal foramina",
      "fenestrae parietales symmetricae",
      "foramina parietalia permagna",
      "hereditary cranium bifidum",
      "parietal foramina",
      "symmetric parietal foramina"
    ],
    "categories": [
      {
        "ref": "MONDO:0002081",
        "name": "musculoskeletal system disorder"
      },
      {
        "ref": "MONDO:0005071",
        "name": "nervous system disorder"
      }
    ],
    "definition": "Enlarged parietal foramina (EPF) is a developmental defect, characterized by variable intramembranous ossification defects of the parietal bones, which is either asymptomatic, symptomatic (headaches, nausea, vomiting, intellectual disability) or associated with other pathologies."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 3,
  "parents": [
    {
      "id": 18236,
      "label": "neural tube defect",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        19709
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0080074",
          "GARD:0018796",
          "ICD9:742.8",
          "MEDGEN:18009",
          "MESH:D009436",
          "NCIT:C84923",
          "Orphanet:3388",
          "SCTID:253098009",
          "UMLS:C0027794"
        ],
        "synonyms": [
          "NTD",
          "spinal dysraphism"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A congenital defect characterized by failure of the neural tube to close completely; this results in the presence of openings in the brain or spinal cord. Examples of neural tube defects include encephalocele and spina bifida."
      },
      "child_count": 12,
      "reference_id": "MONDO:0018075"
    },
    {
      "id": 18360,
      "label": "skeletal dysplasia",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5714,
        7061
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:98053",
          "Orphanet:364526",
          "UMLS:C0410528"
        ],
        "synonyms": [
          "Mendelian skeletal dysplasia",
          "primary bone dysplasia",
          "primary osteodysplasia",
          "primary skeletal dysplasia"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          }
        ],
        "definition": "Any Mendelian diseases that affects growth and development of the skeleton."
      },
      "child_count": 238,
      "reference_id": "MONDO:0018230"
    },
    {
      "id": 24270,
      "label": "hereditary neurological disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5714,
        6799
      ],
      "type_id": 0,
      "properties": {
        "synonyms": [
          "neurogenetic disease"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A heterogeneous group of genetic conditions with Mendelian (autosomal dominant, recessive, or X-linked) or chromosomal etiology characterized by abnormalities in the brain, spinal cord, nerves, or muscles."
      },
      "child_count": 528,
      "reference_id": "MONDO:0100545"
    }
  ],
  "children": [
    {
      "id": 9506,
      "label": "parietal foramina 1",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        18875
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0018051",
          "MEDGEN:401480",
          "MESH:C566827",
          "OMIM:168500",
          "UMLS:C1868599"
        ],
        "synonyms": [
          "MSX2 parietal foramina",
          "parietal foramina 1",
          "parietal foramina caused by mutation in MSX2",
          "PFM",
          "PFM1",
          "catlin Marks",
          "cranium bifidum occultum",
          "cranium bifidum, hereditary",
          "foramina parietalia permagna",
          "parietal foramina",
          "parietal foramina, symmetric"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Any parietal foramina in which the cause of the disease is a mutation in the MSX2 gene."
      },
      "child_count": 0,
      "reference_id": "MONDO:0008197"
    },
    {
      "id": 13358,
      "label": "parietal foramina 3",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        18875
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0018052",
          "MEDGEN:322792",
          "MESH:C563697",
          "OMIM:609566",
          "UMLS:C1835980"
        ],
        "synonyms": [
          "PFM3",
          "parietal foramina 3"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0012302"
    },
    {
      "id": 13365,
      "label": "parietal foramina 2",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        18875
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0018053",
          "MEDGEN:355358",
          "MESH:C566510",
          "OMIM:609597",
          "UMLS:C1865044"
        ],
        "synonyms": [
          "ALX4 parietal foramina",
          "parietal foramina 2",
          "parietal foramina caused by mutation in ALX4",
          "parietal foramina type 2",
          "PFM2"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Any parietal foramina in which the cause of the disease is a mutation in the ALX4 gene."
      },
      "child_count": 0,
      "reference_id": "MONDO:0012309"
    }
  ],
  "roots": [
    {
      "id": 18236,
      "label": "neural tube defect"
    },
    {
      "id": 18360,
      "label": "skeletal dysplasia"
    },
    {
      "id": 24270,
      "label": "hereditary neurological disease"
    }
  ]
}