{
  "id": 18905,
  "label": "iridocorneal endothelial syndrome",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0018988",
  "properties": {
    "xrefs": [
      "GARD:0000060",
      "MEDGEN:242751",
      "MESH:D057129",
      "MedDRA:10053678",
      "NCIT:C84792",
      "Orphanet:64734",
      "SCTID:129623003",
      "UMLS:C1096100",
      "icd11.foundation:265074385"
    ],
    "synonyms": [
      "ICE syndrome"
    ],
    "categories": [
      {
        "ref": "MONDO:0002254",
        "name": "syndromic disease"
      }
    ],
    "definition": "Iridocorneal endothelial (ICE) syndrome describes a group of progressive corneal proliferative endotheliopathies comprised of Chandler syndrome, Cogan-Reese syndrome and essential iris atrophy, affecting mainly young adult females and characterized by iris holes and atrophy, papillary distortion, anterior synechiae, corneal edema and often with secondary glaucoma and corneal decompensation as complications"
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 3,
  "parents": [
    {
      "id": 4370,
      "label": "syndromic disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        29379
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:225",
          "MEDGEN:11688",
          "MESH:D013577",
          "NCIT:C28193",
          "OGMS:0000086",
          "UMLS:C0039082"
        ],
        "synonyms": [
          "cluster, symptom",
          "clusters, symptom",
          "symptom cluster",
          "symptom clusters",
          "syndrome",
          "syndrome associated with disease or disorder",
          "syndromes",
          "syndromic disease",
          "syndromic disease or disorder"
        ],
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          }
        ],
        "definition": "A group of signs, symptoms, and clinicopathological characteristics that may or may not have a genetic basis and collectively define an abnormal condition."
      },
      "child_count": 1182,
      "reference_id": "MONDO:0002254"
    }
  ],
  "children": [
    {
      "id": 19830,
      "label": "Chandler syndrome",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        18261,
        18905
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:11554",
          "GARD:0006033",
          "MEDGEN:107777",
          "MedDRA:10057487",
          "NORD:918",
          "Orphanet:98979",
          "UMLS:C0544008",
          "icd11.foundation:806443940"
        ],
        "synonyms": [
          "Chandler's Syndrome",
          "Chandler's syndrome",
          "endothelial corneal dystrophy"
        ],
        "categories": [
          {
            "ref": "MONDO:0002022",
            "name": "disorder of orbital region"
          },
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0024458",
            "name": "disorder of visual system"
          }
        ],
        "definition": "Chandler syndrome, the most frequent clinical variant of iridocorneal endothelial (ICE) syndrome, is characterized by very few iris abnormalities but more severe corneal edema and less severe secondary glaucoma than seen in the other two ICE syndrome variants: Cogan-Reese syndrome and essential iris atrophy."
      },
      "child_count": 0,
      "reference_id": "MONDO:0020369"
    },
    {
      "id": 19831,
      "label": "Cogan-Reese syndrome",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        18905
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0060217",
          "GARD:0006125",
          "MEDGEN:218910",
          "MedDRA:10059200",
          "NCIT:C84644",
          "Orphanet:98980",
          "SCTID:404633004",
          "UMLS:C1168173",
          "icd11.foundation:1968906450"
        ],
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          }
        ],
        "definition": "Cogan-Reese syndrome is a clinical variant of iridocorneal endothelial (ICE) syndrome characterized by variable iris atrophy, pigmented and pedunculated nodules on the iris and corneal abonormalities. Secondary glaucoma is also a common complication of the disease."
      },
      "child_count": 0,
      "reference_id": "MONDO:0020370"
    },
    {
      "id": 19832,
      "label": "essential iris atrophy",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        18905
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0019611",
          "ICD9:364.51",
          "MEDGEN:543177",
          "NORD:1109",
          "Orphanet:98981",
          "SCTID:25913001",
          "UMLS:C0271111"
        ],
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          }
        ],
        "definition": "Essential iris atrophy is a clinical variant of iridocorneal endothelial (ICE) syndrome, characterized by progressive iris atrophy and holes present on the surface of the iris, corneal edema, corectopia, uveal ectropion and anterior synechiae. Secondary glaucoma is also a common complication of the disease."
      },
      "child_count": 0,
      "reference_id": "MONDO:0020371"
    }
  ],
  "roots": [
    {
      "id": 4370,
      "label": "syndromic disease"
    }
  ]
}