{
  "id": 18908,
  "label": "IgG4-related thyroid disease",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0018992",
  "properties": {
    "xrefs": [
      "DOID:14351",
      "GARD:0018866",
      "MEDGEN:509536",
      "MedDRA:10039142",
      "NCIT:C35827",
      "Orphanet:64744",
      "SCTID:89024000",
      "UMLS:C0154162",
      "icd11.foundation:1357889668"
    ],
    "synonyms": [
      "Riedel disease",
      "Riedel fibrosing thyroiditis",
      "Riedel thyroiditis",
      "Riedel's fibrosing thyroiditis"
    ],
    "categories": [
      {
        "ref": "MONDO:0005046",
        "name": "immune system disorder"
      },
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "Riedel thyroiditis is a fibroinflammatory disorder of the thyroid gland, occurring more frequently in females, characterized a large, hard thyroid mass, and presenting with pressure symptoms (breathing difficulB,ties and dysphagia) or voice hoarseness and aphonia (impingement of recurrent laryngeal nerve). It can often be associated with extracervical fibroinflammatory disorders such as retroperitoneal fibrosis, primary scleroisng cholangitis and autoimmune diseases such as Hashimoto struma, Addison disease, and Biermer disease."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 7262,
      "label": "autoimmune thyroid disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        2997,
        5955
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:0006812",
          "MEDGEN:183088",
          "MESH:D013967",
          "UMLS:C0920350",
          "Wikipedia:Autoimmune_thyroiditis"
        ],
        "synonyms": [
          "autoimmune thyroid gland inflammation",
          "autoimmune thyroiditides",
          "autoimmune thyroiditis",
          "lymphocytic thyroiditides",
          "lymphocytic thyroiditis",
          "lymphomatous thyroiditides",
          "lymphomatous thyroiditis",
          "thyroiditides, autoimmune",
          "thyroiditides, lymphocytic",
          "thyroiditides, lymphomatous",
          "thyroiditis, lymphocytic",
          "thyroiditis, lymphomatous"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "Inflammatory disease of the thyroid gland due to autoimmune responses leading to lymphocytic infiltration of the gland. It is characterized by the presence of circulating thyroid antigen-specific T-cells and thyroid autoantibodies. The clinical signs can range from hypothyroidism to thyrotoxicosis depending on the type of autoimmune thyroiditis."
      },
      "child_count": 10,
      "reference_id": "MONDO:0005623"
    },
    {
      "id": 17611,
      "label": "immunoglobulin G4-related sclerosing disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        8586
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0080356",
          "GARD:0012521",
          "MEDGEN:473761",
          "MedDRA:10071569",
          "NANDO:1200923",
          "NANDO:1200924",
          "NCIT:C95992",
          "Orphanet:284264",
          "Orphanet:596448",
          "UMLS:C3203653",
          "icd11.foundation:99883782"
        ],
        "synonyms": [
          "IgG4-RD",
          "IgG4-related disease",
          "IgG4-related sclerosing disease",
          "IgG4-related systemic disease",
          "immunoglobulin G4-related sclerosing disease",
          "IgG4-associated disease",
          "IgG4-positive multiorgan lymphoproliferative syndrome",
          "IgG4-related autoimmune disease",
          "IgG4-related systemic sclerosing disease",
          "IgG4-syndrome",
          "hyper-IgG4 disease",
          "multifocal fibrosclerosis",
          "multifocal idiopathic fibrosclerosis",
          "systemic IgG4-related plasmacytic syndrome",
          "systemic IgG4-related sclerosing syndrome"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ],
        "definition": "A recently described mass-forming lesion that occurs in the pancreas, submandibular glands, lacrimal glands, lymph nodes, and hepatobiliary tract. It is characterized by the presence of marked tissue sclerosis and infiltration by numerous plasma cells. The plasma cells show immunohistochemical staining for IgG4 and the serum IgG4 levels are often increased."
      },
      "child_count": 14,
      "reference_id": "MONDO:0017287"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 7262,
      "label": "autoimmune thyroid disease"
    },
    {
      "id": 17611,
      "label": "immunoglobulin G4-related sclerosing disease"
    }
  ]
}