{
  "id": 18919,
  "label": "kidney Wilms tumor",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0019004",
  "properties": {
    "xrefs": [
      "DOID:2154",
      "DOID:5176",
      "GARD:0007892",
      "ICDO:8960/3",
      "MedDRA:10029145",
      "NANDO:2200043",
      "NCIT:C40407",
      "NORD:1855",
      "ONCOTREE:WT",
      "Orphanet:654",
      "SCTID:302849000"
    ],
    "synonyms": [
      "Wilms tumor",
      "Wilms tumour",
      "Wilms' tumor",
      "Wilms' tumour",
      "Wilms tumor of the kidney",
      "Wilms tumour of the kidney",
      "Wilms' Tumor",
      "Wilms' tumor of the kidney",
      "Wilms' tumour of the kidney",
      "kidney Wilms tumor",
      "nephroblastoma",
      "nephroblastoma, malignant",
      "renal Wilms tumor",
      "renal Wilms tumour",
      "renal Wilms' tumor",
      "renal embryonic tumor",
      "renal embryonic tumour",
      "adult nephroblastoma",
      "adult renal Wilms' tumour",
      "childhood renal Wilms tumor",
      "childhood renal Wilms tumour",
      "childhood renal Wilms' cancer",
      "embryonal nephroma",
      "nonanaplastic renal Wilm's tumor",
      "nonanaplastic renal Wilm's tumour"
    ],
    "categories": [
      {
        "ref": "MONDO:0002118",
        "name": "urinary system disorder"
      }
    ],
    "definition": "An embryonal pediatric tumor of the kidney which may also be seen rarely in adults. The peak incidence of Wilms tumor is between the second and fifth year of life. Microscopically, it is composed of a mixture of cellular elements (blastemal, stromal, and epithelial). The most common sites of metastasis include the regional lymph nodes, lungs, and liver."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 8,
  "parents": [
    {
      "id": 4465,
      "label": "kidney cancer",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7836,
        20396
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:263",
          "ICD9:189.0",
          "MEDGEN:149263",
          "MESH:D007680",
          "NCIT:C7548",
          "SCTID:363518003",
          "UMLS:C0740457"
        ],
        "synonyms": [
          "cancer of kidney",
          "kidney cancer",
          "malignant kidney neoplasm",
          "malignant kidney tumor",
          "malignant kidney tumour",
          "malignant neoplasm of kidney",
          "malignant neoplasm of the kidney",
          "malignant renal neoplasm",
          "malignant renal tumor",
          "malignant renal tumour",
          "malignant tumor of kidney",
          "malignant tumor of the kidney",
          "malignant tumour of the kidney"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          }
        ],
        "definition": "Primary or metastatic malignant neoplasm involving the kidney."
      },
      "child_count": 16,
      "reference_id": "MONDO:0002367"
    },
    {
      "id": 7641,
      "label": "Wilms tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7212,
        7464
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0027737",
          "MEDGEN:10221",
          "MESH:D009396",
          "NCIT:C3267",
          "UMLS:C0027708"
        ],
        "synonyms": [
          "Wilms tumor",
          "Wilms' tumor",
          "Wilms' tumour",
          "Wilms tumor (nephroblastoma)",
          "Wilms tumour (nephroblastoma)"
        ],
        "definition": "An embryonal neoplasm characterized by the presence of epithelial, mesenchymal, and blastema components. The vast majority of cases arise from the kidney. A small number of cases with morphologic features resembling Wilms tumor of the kidney have been reported arising from the ovary and the cervix."
      },
      "child_count": 8,
      "reference_id": "MONDO:0006058"
    }
  ],
  "children": [
    {
      "id": 5256,
      "label": "nonanaplastic kidney Wilms tumor",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        18919
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0023443",
          "MEDGEN:277434",
          "NCIT:C6951",
          "UMLS:C1335062"
        ],
        "synonyms": [
          "nonanaplastic kidney Wilms tumor",
          "nonanaplastic renal Wilm's tumor",
          "nonanaplastic renal Wilm's tumour",
          "nonanaplastic renal Wilms tumor",
          "nonanaplastic renal Wilms tumour",
          "nonanaplastic renal Wilms' tumor",
          "nonanaplastic renal Wilms' tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          }
        ],
        "definition": "Wilms tumor of the kidney characterized by the absence of nuclear anaplasia."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003316"
    },
    {
      "id": 5257,
      "label": "metachronous kidney Wilms' tumor",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        18919
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5178",
          "GARD:0023444",
          "MEDGEN:233696",
          "NCIT:C38158",
          "UMLS:C1334705"
        ],
        "synonyms": [
          "metachronous Wilms tumor",
          "metachronous Wilms tumor of the kidney",
          "metachronous Wilms tumour",
          "metachronous Wilms tumour of the kidney",
          "metachronous Wilms' tumor",
          "metachronous Wilms' tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          }
        ],
        "definition": "Wilms tumor arising in the remaining kidney following treatment of the original Wilms tumor."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003317"
    },
    {
      "id": 5258,
      "label": "mixed cell type kidney Wilms' tumor",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        18919
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5179",
          "GARD:0023445",
          "MEDGEN:76001",
          "NCIT:C9149",
          "UMLS:C0279611"
        ],
        "synonyms": [
          "Mixed cell type Wilms tumor",
          "Mixed cell type Wilms tumour",
          "mixed cell type kidney Wilms tumor",
          "mixed cell type kidney Wilms tumour",
          "mixed cell type kidney adenosarcoma",
          "mixed cell type nephroblastoma",
          "mixed cell type renal Wilm's tumor",
          "mixed cell type renal Wilm's tumour",
          "mixed cell type renal Wilms tumor",
          "mixed cell type renal Wilms' tumor",
          "mixed cell type renal Wilms' tumour",
          "mixed cell type renal adenosarcoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          }
        ],
        "definition": "Wilms tumor of the kidney characterized by the presence of blastema, epithelial, and mesenchymal components (triphasic pattern) or a combination of two of them (biphasic pattern)."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003318"
    },
    {
      "id": 5260,
      "label": "blastema predominant kidney Wilms tumor",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        18919
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5182",
          "GARD:0023446",
          "MEDGEN:83528",
          "NCIT:C9147",
          "UMLS:C0279609"
        ],
        "synonyms": [
          "blastema predominant Wilms tumor",
          "blastema predominant Wilms tumour",
          "blastema predominant kidney Wilms tumor",
          "blastema predominant kidney adenosarcoma",
          "blastema predominant nephroblastoma",
          "blastema predominant renal Wilm's tumor",
          "blastema predominant renal Wilm's tumour",
          "blastema predominant renal Wilms tumor",
          "blastema predominant renal Wilms' tumor",
          "blastema predominant renal Wilms' tumour",
          "blastema predominant renal adenosarcoma",
          "blastema predominant kidney Wilms' tumor",
          "blastema predominant kidney Wilms' tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          }
        ],
        "definition": "Wilms tumor of the kidney characterized by the predominance of the blastema component."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003320"
    },
    {
      "id": 5262,
      "label": "epithelial predominant Wilms' tumor",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        18919
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5189",
          "GARD:0023448",
          "MEDGEN:76000",
          "NCIT:C9146",
          "UMLS:C0279608"
        ],
        "synonyms": [
          "epithelial predominant Wilms tumor",
          "epithelial predominant Wilms tumour",
          "epithelial predominant kidney Wilms tumor",
          "epithelial predominant kidney Wilms tumour",
          "epithelial predominant kidney adenosarcoma",
          "epithelial predominant nephroblastoma",
          "epithelial predominant renal Wilm's tumor",
          "epithelial predominant renal Wilm's tumour",
          "epithelial predominant renal Wilms tumor",
          "epithelial predominant renal Wilms' tumor",
          "epithelial predominant renal Wilms' tumour",
          "epithelial predominant renal adenosarcoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          }
        ],
        "definition": "Wilms tumor of the kidney characterized by the predominance of the epithelial component. The epithelial cells may form papillary and tubular patterns and pseudorosettes."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003322"
    },
    {
      "id": 7947,
      "label": "stromal predominant kidney Wilms tumor",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        18919
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5191",
          "GARD:0024411",
          "MEDGEN:83529",
          "NCIT:C9148",
          "UMLS:C0279610"
        ],
        "synonyms": [
          "stromal predominant Wilms tumor",
          "stromal predominant Wilms tumour",
          "stromal predominant kidney Wilms tumor",
          "stromal predominant kidney Wilms' tumor",
          "stromal predominant kidney adenosarcoma",
          "stromal predominant nephroblastoma",
          "stromal predominant renal Wilm's tumor",
          "stromal predominant renal Wilm's tumour",
          "stromal predominant renal Wilms tumor",
          "stromal predominant renal Wilms' tumor",
          "stromal predominant renal Wilms' tumour",
          "stromal predominant renal adenosarcoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          }
        ],
        "definition": "Wilms tumor of the kidney characterized by the predominance of the mesenchymal component."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006432"
    },
    {
      "id": 21576,
      "label": "adult kidney Wilms tumor",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        18919
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0025456",
          "MEDGEN:231045",
          "NCIT:C6180",
          "UMLS:C1332219"
        ],
        "synonyms": [
          "adenosarcoma of adult kidney",
          "adenosarcoma of the adult kidney",
          "adult kidney Wilms tumor",
          "adult kidney adenosarcoma",
          "adult nephroblastoma",
          "adult renal Wilms tumor",
          "adult renal Wilms tumour",
          "adult renal Wilms' tumor",
          "adult renal Wilms' tumour",
          "adult renal adenosarcoma",
          "kidney Wilms tumor of adults",
          "kidney Wilms tumour of adults"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          }
        ],
        "definition": "Wilms tumor of the kidney which occurs in adults."
      },
      "child_count": 0,
      "reference_id": "MONDO:0024675"
    },
    {
      "id": 21577,
      "label": "childhood kidney Wilms tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        18919,
        22942
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0025457",
          "MEDGEN:232073",
          "NCIT:C27730",
          "UMLS:C1333015"
        ],
        "synonyms": [
          "Wilms tumor",
          "Wilms tumour",
          "kidney Wilms tumor",
          "kidney Wilms tumour",
          "childhood Wilms tumor",
          "childhood Wilms tumour",
          "childhood kidney Wilms tumor",
          "childhood renal Wilms tumor",
          "childhood renal Wilms tumour",
          "childhood renal Wilms' tumor",
          "childhood renal Wilms' tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          }
        ],
        "definition": "A Wilms tumor of the kidney which occurs in children."
      },
      "child_count": 2,
      "reference_id": "MONDO:0024676"
    }
  ],
  "roots": [
    {
      "id": 4465,
      "label": "kidney cancer"
    },
    {
      "id": 7641,
      "label": "Wilms tumor"
    }
  ]
}