{
  "id": 18936,
  "label": "cutaneous mastocytosis",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0019023",
  "properties": {
    "xrefs": [
      "DOID:3663",
      "EFO:1000886",
      "GARD:0007842",
      "HP:0200151",
      "ICD10CM:D47.01",
      "ICDO:9740/1",
      "MEDGEN:210143",
      "MESH:D034701",
      "NCIT:C7137",
      "OMIM:154800",
      "ONCOTREE:CMCD",
      "Orphanet:66646",
      "SCTID:397012002",
      "UMLS:C1136033",
      "icd11.foundation:1300710062"
    ],
    "synonyms": [
      "CM",
      "cutaneous (skin) mastocytosis",
      "cutaneous mastocytosis",
      "cutaneous mastocytosis (disease)",
      "mastocytosis, cutaneous",
      "mastocytosis, systemic, somatic",
      "CMCD"
    ],
    "categories": [
      {
        "ref": "MONDO:0002051",
        "name": "integumentary system disorder"
      },
      {
        "ref": "MONDO:0005046",
        "name": "immune system disorder"
      },
      {
        "ref": "MONDO:0005570",
        "name": "hematologic disorder"
      }
    ],
    "definition": "Cutaneous mastocytosis is a term referring to a group of diseases characterized by abnormal accumulation and proliferation of skin mastocytes. In some cases (most commonly in adults), cutaneous mastocytosis may occur in association with mast cell infiltration of various extracutaneous organs, in which case the disorder is referred to as systemic mastocytosis."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 3,
  "parents": [
    {
      "id": 4409,
      "label": "dermis tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4599,
        20387
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2438",
          "GARD:0023112",
          "MEDGEN:91075",
          "NCIT:C4475",
          "UMLS:C0346041"
        ],
        "synonyms": [
          "dermal neoplasm",
          "dermal tumor",
          "dermal tumour",
          "dermis neoplasm",
          "dermis neoplasm (disease)",
          "dermis tumor",
          "neoplasm of dermis",
          "neoplasm of the dermis",
          "tumor of dermis",
          "tumor of the dermis",
          "tumour of the dermis"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ],
        "definition": "A benign, intermediate, or malignant neoplasm that arises from the dermis."
      },
      "child_count": 16,
      "reference_id": "MONDO:0002300"
    },
    {
      "id": 7148,
      "label": "urticaria",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4496
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1555",
          "EFO:0005531",
          "HP:0001025",
          "ICD10CM:L50",
          "ICD10WHO:L50",
          "ICD9:708",
          "ICD9:708.8",
          "ICD9:708.9",
          "MEDGEN:22587",
          "MESH:D014581",
          "NCIT:C3432",
          "SCTID:126485001",
          "UMLS:C0042109"
        ],
        "synonyms": [
          "hives",
          "urticaria",
          "urticaria (disease)",
          "Urticarias"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ],
        "definition": "A vascular reaction of the skin characterized by erythema and wheal formation due to localized increase of vascular permeability. The causative mechanism may be allergy, infection, or stress."
      },
      "child_count": 14,
      "reference_id": "MONDO:0005492"
    },
    {
      "id": 9280,
      "label": "mastocytosis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4762,
        6569
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:350",
          "EFO:0009001",
          "GARD:0006987",
          "ICD10WHO:Q82.2",
          "MEDGEN:9902",
          "MESH:D008415",
          "MedDRA:10026891",
          "NCIT:C84269",
          "NORD:1408",
          "ONCOTREE:MCD",
          "Orphanet:98292",
          "UMLS:C0024899",
          "icd11.foundation:691643472"
        ],
        "synonyms": [
          "Mast cell disease",
          "mastocytosis",
          "MAST cell disease",
          "urticaria pigmentosa"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A clonal myeloproliferative neoplasm characterized by the proliferation and accumulation of neoplastic mast cells in one or multiple organs or organ systems. It is a heterogeneous group of neoplasms, ranging from cutaneous proliferations which may regress spontaneously, to aggressive neoplasms associated with organ failure and short survival."
      },
      "child_count": 10,
      "reference_id": "MONDO:0007950"
    }
  ],
  "children": [
    {
      "id": 19155,
      "label": "cutaneous mastocytoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        18936
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0012687",
          "MEDGEN:83357",
          "Orphanet:79455",
          "UMLS:C0343115",
          "icd11.foundation:1853236564"
        ],
        "synonyms": [
          "cutaneous local mastocytoma",
          "multiple mastocytoma",
          "solitary mastocytoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "Cutaneous mastocytoma is a form of cutaneous mastocytosis (CM) generally characterized by the presence of a solitary or multiple hyperpigmented macules, plaques or nodules associated with abnormal accumulation of mast cells in the skin."
      },
      "child_count": 1,
      "reference_id": "MONDO:0019314"
    },
    {
      "id": 19156,
      "label": "diffuse cutaneous mastocytosis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        18936
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3665",
          "GARD:0012686",
          "ICDO:9740/1",
          "MEDGEN:44303",
          "MedDRA:10012812",
          "NCIT:C3218",
          "Orphanet:79456",
          "UMLS:C0024901",
          "icd11.foundation:193128939"
        ],
        "synonyms": [
          "DCM",
          "diffuse cutaneous maculopapulous mastocytosis",
          "diffuse cutaneous mastocytosis"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "Diffuse cutaneous mastocytosis (DCM) is a rare form of cutaneous mastocytosis (CM) characterized by generalized erythroderma, various degrees of blistering, skin with a ''peau d'orange'' appearance and the accumulation of mast cells in the skin. At least two DCM variants are recognized, one with extreme blistering (Bullous DCM) and one with infiltrations (Pseudoxanthomatous DCM)."
      },
      "child_count": 2,
      "reference_id": "MONDO:0019315"
    },
    {
      "id": 19157,
      "label": "maculopapular cutaneous mastocytosis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        18936
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:12309",
          "EFO:1001229",
          "GARD:0016723",
          "ICD9:708.8",
          "ICDO:9740/1",
          "MEDGEN:22588",
          "MedDRA:10046752",
          "NCIT:C3433",
          "Orphanet:79457",
          "SCTID:78745000",
          "UMLS:C0042111",
          "icd11.foundation:245322245"
        ],
        "synonyms": [
          "UP/MPCM",
          "urticaria pigmentosa",
          "urticaria pigmentosa/maculopapular cutaneous mastocytosis",
          "Paucicellular mastocytosis",
          "telangiectasia macularis eruptive perstans",
          "telangiectatic cutaneous mastocytosis"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "Maculopapular cutaneous mastocytosis (MCM) is a form of cutaneous mastocytosis (CM) characterized by the presence of multiple hyperpigmented macules, papules or nodules associated with abnormal accumulation of mast cells in the skin."
      },
      "child_count": 4,
      "reference_id": "MONDO:0019316"
    }
  ],
  "roots": [
    {
      "id": 4409,
      "label": "dermis tumor"
    },
    {
      "id": 7148,
      "label": "urticaria"
    },
    {
      "id": 9280,
      "label": "mastocytosis"
    }
  ]
}