{
  "id": 18977,
  "label": "carcinoma of esophagus",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0019086",
  "properties": {
    "xrefs": [
      "DOID:1107",
      "EFO:0002916",
      "GARD:0006383",
      "MEDGEN:56256",
      "MedDRA:10030155",
      "NCIT:C3513",
      "Orphanet:70482",
      "SCTID:372138000",
      "UMLS:C0152018"
    ],
    "synonyms": [
      "Esophageal cancer",
      "carcinoma of esophagus",
      "carcinoma of the esophagus",
      "carcinoma of the oesophagus",
      "esophageal carcinoma",
      "esophagus carcinoma",
      "oesophagus carcinoma",
      "cancer of esophagus",
      "cancer of oesophagus",
      "cancer of the esophagus",
      "cancer of the oesophagus",
      "esophageal cancer",
      "esophageal cancer, NOS"
    ],
    "categories": [
      {
        "ref": "MONDO:0004335",
        "name": "digestive system disorder"
      }
    ],
    "definition": "Esophageal carcinoma (EC) is a tumor arising in the epithelial cells lining the esophagus and can be divided into two subtypes: esophageal squamous cell carcinoma (ESCC) and esophageal adenocarcinoma (EAC)."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 5,
  "parents": [
    {
      "id": 7738,
      "label": "digestive system carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4587,
        6734
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050922",
          "EFO:1000218",
          "HP:0002672",
          "MEDGEN:57467",
          "NCIT:C96963",
          "UMLS:C0151544"
        ],
        "synonyms": [
          "carcinoma of digestive system",
          "carcinoma of the gastrointestinal system",
          "digestive system carcinoma",
          "gastrointestinal carcinoma",
          "gastrointestinal carcinoma (disease)",
          "gastrointestinal system carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "A malignant neoplasm that arises from the epithelium of any part of the digestive system. Representative examples include colorectal carcinoma, esophageal carcinoma, and pancreatic carcinoma."
      },
      "child_count": 32,
      "reference_id": "MONDO:0006181"
    },
    {
      "id": 8953,
      "label": "esophageal cancer",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4587,
        20522
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5041",
          "GARD:0027778",
          "ICD10CM:C15",
          "ICD9:150.3",
          "ICD9:150.4",
          "ICD9:150.5",
          "ICD9:150.8",
          "ICD9:150.9",
          "MEDGEN:107792",
          "NCIT:C7478",
          "OMIM:133239",
          "SCTID:363402007",
          "UMLS:C0546837",
          "icd11.foundation:669033105"
        ],
        "synonyms": [
          "cancer of esophagus",
          "cancer of oesophagus",
          "esophageal cancer",
          "esophageal cancer, somatic",
          "esophageal carcinoma, somatic",
          "esophageal squamous cell carcinoma, somatic",
          "esophagus cancer",
          "malignant esophageal neoplasm",
          "malignant esophageal tumor",
          "malignant esophageal tumour",
          "malignant esophagus neoplasm",
          "malignant esophagus tumor",
          "malignant neoplasm of esophagus",
          "malignant neoplasm of oesophagus",
          "malignant neoplasm of the esophagus",
          "malignant neoplasm of the oesophagus",
          "malignant oesophagus neoplasm",
          "malignant oesophagus tumour",
          "malignant tumor of esophagus",
          "malignant tumor of the esophagus",
          "malignant tumour of oesophagus",
          "malignant tumour of the oesophagus",
          "oesophagus cancer",
          "Ca lower third esophagus",
          "Ca lower third oesophagus",
          "Ca middle third esophagus",
          "Ca middle third oesophagus",
          "malignant neoplasm of distal third of esophagus",
          "malignant neoplasm of distal third of oesophagus",
          "malignant neoplasm of lower third of esophagus",
          "malignant neoplasm of lower third of oesophagus",
          "malignant neoplasm of middle third of esophagus",
          "malignant neoplasm of middle third of oesophagus",
          "malignant neoplasm of proximal third of esophagus",
          "malignant neoplasm of proximal third of oesophagus",
          "malignant neoplasm of upper third esophagus",
          "malignant neoplasm of upper third oesophagus",
          "malignant tumor of abdominal esophagus",
          "malignant tumor of distal third of esophagus",
          "malignant tumor of proximal third of esophagus",
          "malignant tumor of the middle third of the esophagus",
          "malignant tumour of abdominal oesophagus",
          "malignant tumour of distal third of oesophagus",
          "malignant tumour of proximal third of oesophagus",
          "malignant tumour of the middle third of the oesophagus",
          "Aerodigestive tract cancer, susceptibility to",
          "Escc, susceptibility to",
          "esophageal squamous cell carcinoma, susceptibility to",
          "gastric cardia adenocarcinoma, susceptibility to"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "A primary or metastatic malignant neoplasm involving the esophagus."
      },
      "child_count": 14,
      "reference_id": "MONDO:0007576"
    }
  ],
  "children": [
    {
      "id": 5948,
      "label": "esophageal small cell neuroendocrine carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        2894,
        5537,
        18977
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7134",
          "GARD:0023832",
          "MEDGEN:207270",
          "NCIT:C6762",
          "UMLS:C1112474"
        ],
        "synonyms": [
          "Oat cell carcinoma of esophagus",
          "Oat cell carcinoma of the esophagus",
          "Oat cell carcinoma of the oesophagus",
          "esophageal Oat cell carcinoma",
          "esophageal small cell NEC",
          "esophageal small cell carcinoma",
          "esophageal small cell neuroendocrine carcinoma",
          "esophagus Oat cell carcinoma",
          "esophagus small cell carcinoma",
          "oesophagus Oat cell carcinoma",
          "small cell carcinoma of esophagus",
          "small cell carcinoma of oesophagus",
          "small cell carcinoma of the esophagus",
          "small cell carcinoma of the oesophagus",
          "small cell carcinoma, esophagus",
          "small cell carcinoma, oesophagus"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "An aggressive, high-grade and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the esophagus. It is characterized by the presence of malignant small cells."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004116"
    },
    {
      "id": 6487,
      "label": "esophagus carcinoma in situ",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6433,
        18977
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:9095",
          "GARD:0024094",
          "ICD10CM:D00.1",
          "ICD9:230.1",
          "MEDGEN:56332",
          "NCIT:C89771",
          "SCTID:92585006",
          "UMLS:C0154059",
          "icd11.foundation:218644880"
        ],
        "synonyms": [
          "carcinoma in situ of esophagus",
          "carcinoma in situ of oesophagus",
          "esophageal carcinoma in situ",
          "esophageal carcinoma in situ aJCC v7",
          "esophagus in situ carcinoma",
          "oesophagus in situ carcinoma",
          "severe esophageal dysplasia",
          "severe esophageal dysplasia aJCC v7",
          "stage 0 esophageal cancer",
          "stage 0 esophageal cancer aJCC v7",
          "stage 0 esophageal carcinoma in situ",
          "stage 0 esophagus carcinoma",
          "stage 0 oesophagus carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "Stage 0 includes: For squamous cell carcinoma: Tis (HGD), N0, M0, G1, GX, Tumor location: Any. For adenocarcinoma: Tis (HGD), N0, M0, G1, GX. Tis: High-grade dysplasia. N0: No regional lymph node metastasis. M0: No distant metastasis. G1: Well differentiated. GX: Grade cannot be assessed-stage grouping as G1. Tumor location: Location of the primary cancer site is defined by the position of the upper (proximal) edge of the tumor in the esophagus. (AJCC 7th ed.)"
      },
      "child_count": 0,
      "reference_id": "MONDO:0004708"
    },
    {
      "id": 6762,
      "label": "esophageal adenocarcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6712,
        18977
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4914",
          "EFO:0000478",
          "GARD:0016927",
          "MEDGEN:124636",
          "NCIT:C4025",
          "ONCOTREE:ESCA",
          "Orphanet:99976",
          "SCTID:276803003",
          "UMLS:C0279628",
          "icd11.foundation:829915640"
        ],
        "synonyms": [
          "adenocarcinoma - esophagus",
          "adenocarcinoma - oesophagus",
          "adenocarcinoma of esophagus",
          "adenocarcinoma of oesophagus",
          "adenocarcinoma of the esophagus",
          "adenocarcinoma of the oesophagus",
          "esophageal adenocarcinoma",
          "esophagus adenocarcinoma",
          "oesophageal adenocarcinoma",
          "oesophagus adenocarcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "A malignant tumor with glandular differentiation arising predominantly from Barrett mucosa in the lower third of the esophagus. Rare examples of esophageal adenocarcinoma deriving from ectopic gastric mucosa in the upper esophagus have also been reported. Grossly, esophageal adenocarcinomas are similar to esophageal squamous cell carcinomas. Microscopically, adenocarcinomas arising in the setting of Barrett esophagus are typically papillary and/or tubular. The prognosis is poor."
      },
      "child_count": 6,
      "reference_id": "MONDO:0005028"
    },
    {
      "id": 7225,
      "label": "esophageal squamous cell carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6823,
        18977
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3748",
          "EFO:0005922",
          "GARD:0018901",
          "MEDGEN:124635",
          "MESH:C562729",
          "MESH:D000077277",
          "NCIT:C4024",
          "ONCOTREE:ESCC",
          "Orphanet:99977",
          "SCTID:276804009",
          "UMLS:C0279626",
          "icd11.foundation:1417891145"
        ],
        "synonyms": [
          "ESCC",
          "esophageal epidermoid carcinoma",
          "esophageal scc",
          "esophageal squamous cell cancer",
          "esophageal squamous cell carcinoma",
          "esophagus scc",
          "esophagus squamous cell carcinoma",
          "oesophagus scc",
          "scc of esophagus",
          "scc of the esophagus",
          "scc of the oesophagus",
          "squamous cell car. - esophagus",
          "squamous cell car. - oesophagus",
          "squamous cell carcinoma of esophagus",
          "squamous cell carcinoma of oesophagus",
          "squamous cell carcinoma of the esophagus",
          "squamous cell carcinoma of the oesophagus"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "Esophageal squamous cell carcinoma (ESCC) is a type of esophageal carcinoma (EC) that can affect any part of the esophagus, but is usually located in the upper or middle third."
      },
      "child_count": 8,
      "reference_id": "MONDO:0005580"
    },
    {
      "id": 18519,
      "label": "carcinoma of esophagus, salivary gland type",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        18977
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0021741",
          "MEDGEN:1678006",
          "Orphanet:418945",
          "UMLS:C5190854"
        ],
        "synonyms": [
          "esophageal carcinoma, salivary gland type"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0018480"
    }
  ],
  "roots": [
    {
      "id": 7738,
      "label": "digestive system carcinoma"
    },
    {
      "id": 8953,
      "label": "esophageal cancer"
    }
  ]
}