{
  "id": 18978,
  "label": "cholangiocarcinoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0019087",
  "properties": {
    "xrefs": [
      "DOID:4947",
      "EFO:0005221",
      "GARD:0009304",
      "ICDO:8160/3",
      "MEDGEN:60210",
      "MESH:D018281",
      "MedDRA:10004593",
      "MedDRA:10008593",
      "NCIT:C4436",
      "NORD:926",
      "ONCOTREE:CHOL",
      "Orphanet:70567",
      "SCTID:312104005",
      "UMLS:C0206698",
      "icd11.foundation:2110597275"
    ],
    "synonyms": [
      "bile duct cancer",
      "intrahepatic bile duct cancer (cholangiocarcinoma)",
      "CC",
      "CCA",
      "Cholangiocar.- intra/extrahepatic",
      "Cholangiocellular carcinoma",
      "cholangiocarcinoma",
      "cholangiocarcinoma, intrahepatic and extrahepatic bile ducts (adenocarcinoma)",
      "cholangiocarcinoma, malignant"
    ],
    "categories": [
      {
        "ref": "MONDO:0004335",
        "name": "digestive system disorder"
      },
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "A carcinoma that arises from the intrahepatic biliary tree (intrahepatic cholangiocarcinoma) or from the junction, or adjacent to the junction, of the right and left hepatic ducts (hilar cholangiocarcinoma). Grossly, the malignant lesions are solid, nodular, and grayish. Morphologically, the vast majority of cases are adenocarcinomas. Signs and symptoms include malaise, weight loss, right upper quadrant abdominal pain, and night sweats. Early detection is difficult and the prognosis is generally poor."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 1,
  "parents": [
    {
      "id": 18555,
      "label": "adenocarcinoma of gallbladder and extrahepatic biliary tract",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4714,
        18842
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0021791",
          "MEDGEN:1633887",
          "Orphanet:424991",
          "SCTID:765741003",
          "UMLS:C4707555"
        ],
        "synonyms": [
          "adenocarcinoma of gallbladder and EBT",
          "adenocarcinoma of the gallbladder and EBT",
          "adenocarcinoma of the gallbladder and extrahepatic biliary tract"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "Adenocarcinoma of the gallbladder and extrahepatic biliary tract is a rare epithelial carcinoma, arising either in the gallbladder itself or from the epithelium lining the extrahepatic biliary tree, cystic duct and/or peribiliary gland, characterized by nonspecific symptoms, such as abdominal pain, jaundice and vomiting and sometimes mimicking benign biliary diseases. Chronic biliary epithelial inflammation (e.g. primary sclerosing cholangitis, cholelithiasis, choledocholithiasis, liver fluke infestation) is a major risk factor."
      },
      "child_count": 4,
      "reference_id": "MONDO:0018536"
    }
  ],
  "children": [
    {
      "id": 5166,
      "label": "intrahepatic cholangiocarcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3698,
        18978
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4928",
          "EFO:1001961",
          "GARD:0006042",
          "ICD10CM:C22.1",
          "MEDGEN:87521",
          "NCIT:C35417",
          "ONCOTREE:IHCH",
          "SCTID:109842005",
          "UMLS:C0345905",
          "icd11.foundation:1253728223",
          "icd11.foundation:387909164"
        ],
        "synonyms": [
          "ICC",
          "cholangiocarcinoma, intrahepatic, malignant",
          "intrahepatic Cholangiocellular carcinoma",
          "intrahepatic bile duct cancer (cholangiocarcinoma)",
          "intrahepatic bile duct carcinoma",
          "intrahepatic carcinoma of bile duct",
          "intrahepatic carcinoma of the bile duct",
          "intrahepatic cholangiocarcinoma",
          "intrahepatic cholangiocarcinoma (bile duct cancer)",
          "IHCH"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A carcinoma that arises from the intrahepatic bile duct epithelium in any site of the intrahepatic biliary tree. Grossly, the malignant lesions are solid, nodular, and grayish. Morphologically, the vast majority of cases are adenocarcinomas. Signs and symptoms include malaise, weight loss, right upper quadrant abdominal pain, and night sweats. Early detection is difficult and the prognosis is generally poor."
      },
      "child_count": 12,
      "reference_id": "MONDO:0003210"
    }
  ],
  "roots": [
    {
      "id": 18555,
      "label": "adenocarcinoma of gallbladder and extrahepatic biliary tract"
    }
  ]
}