{
  "id": 18995,
  "label": "familial thrombocytosis",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0019111",
  "properties": {
    "xrefs": [
      "GARD:0016688",
      "MEDGEN:929430",
      "OMIMPS:187950",
      "Orphanet:71493",
      "SCTID:720950009",
      "UMLS:C4303761",
      "icd11.foundation:1695088249"
    ],
    "synonyms": [
      "THCYT",
      "familial thrombocythemia",
      "hereditary thrombocythemia",
      "hereditary thrombocytosis",
      "hereditary thrombocytosis disease",
      "thrombocythemia"
    ],
    "categories": [
      {
        "ref": "MONDO:0005570",
        "name": "hematologic disorder"
      }
    ],
    "definition": "Familial thrombocytosis is a type of thrombocytosis, a sustained elevation of platelet numbers, which affects the platelet/megakaryocyte lineage and may create a tendency for thrombosis and hemorrhage but does not cause myeloproliferation."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 3,
  "parents": [
    {
      "id": 4365,
      "label": "thrombocytosis disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4362
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2228",
          "ICD9:289.9",
          "MEDGEN:163397",
          "MESH:D013922",
          "NCIT:C35530",
          "SCTID:6631009",
          "UMLS:C0836924"
        ],
        "synonyms": [
          "Platelet count increased",
          "elevated Platelet count",
          "thrombocytosis"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A disease characterized by higher than normal platelet counts in the peripheral blood."
      },
      "child_count": 3,
      "reference_id": "MONDO:0002249"
    },
    {
      "id": 5714,
      "label": "hereditary disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        29382
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:630",
          "EFO:0000508",
          "ICD9:799.89",
          "MEDGEN:5527",
          "MESH:D030342",
          "NCIT:C3101",
          "SCTID:32895009",
          "UMLS:C0019247"
        ],
        "synonyms": [
          "genetic condition",
          "genetic disease",
          "genetic disorder",
          "hereditary disease",
          "hereditary disease or disorder",
          "hereditary diseases",
          "inherited disease",
          "inherited genetic disease",
          "molecular disease",
          "Mendelian disease",
          "familial disorder",
          "inborn disorder"
        ],
        "definition": "A disease that is caused by genetic modifications where those modifications are inherited from a parent's genome."
      },
      "child_count": 1925,
      "reference_id": "MONDO:0003847"
    }
  ],
  "children": [
    {
      "id": 9841,
      "label": "thrombocythemia 1",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        18995,
        19479
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0024630",
          "MEDGEN:479301",
          "OMIM:187950",
          "UMLS:C3277671"
        ],
        "synonyms": [
          "thrombocythemia 1",
          "thrombocythemia type 1",
          "thrombocythemia, somatic",
          "THCYT1",
          "thrombocytosis 1"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0008554"
    },
    {
      "id": 12295,
      "label": "thrombocythemia 2",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        18995
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0024778",
          "MEDGEN:477629",
          "OMIM:601977",
          "UMLS:C3275998"
        ],
        "synonyms": [
          "MPL familial thrombocytosis",
          "familial thrombocytosis caused by mutation in MPL",
          "thrombocythemia 2",
          "thrombocythemia 2, autosomal dominant, somatic mutation",
          "thrombocythemia type 2",
          "THCYT2"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "Familial thrombocytosis in which the cause of the disease is a mutation in the MPL gene."
      },
      "child_count": 0,
      "reference_id": "MONDO:0011173"
    },
    {
      "id": 14812,
      "label": "thrombocythemia 3",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        18995
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0024950",
          "MEDGEN:482755",
          "OMIM:614521",
          "UMLS:C3281125"
        ],
        "synonyms": [
          "JAK2 familial thrombocytosis",
          "familial thrombocytosis caused by mutation in JAK2",
          "thrombocythemia 3",
          "thrombocythemia 3, autosomal dominant, somatic mutation",
          "thrombocythemia type 3",
          "THCYT3",
          "thrombocytosis 3"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "Familial thrombocytosis in which the cause of the disease is a mutation in the JAK2 gene."
      },
      "child_count": 0,
      "reference_id": "MONDO:0013794"
    }
  ],
  "roots": [
    {
      "id": 4365,
      "label": "thrombocytosis disease"
    },
    {
      "id": 5714,
      "label": "hereditary disease"
    }
  ]
}