{
  "id": 19017,
  "label": "acquired hemophilia",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0019139",
  "properties": {
    "xrefs": [
      "GARD:0010350",
      "ICD10CM:D68.311",
      "MEDGEN:204253",
      "MedDRA:10053745",
      "NANDO:1200898",
      "Orphanet:73274",
      "UMLS:C1096116"
    ],
    "synonyms": [
      "acquired hemophilia",
      "hemophilia, acquired"
    ],
    "categories": [
      {
        "ref": "MONDO:0005570",
        "name": "hematologic disorder"
      }
    ],
    "definition": "Acquired hemophilia is a bleeding disorder that interferes with the body's blood clotting process. Signs and symptoms include prolonged bleeding, frequent nosebleeds, bruising throughout the body, solid swellings of congealed blood (hematomas), hematuria, and gastrointestinal or urologic bleeding. Acquired hemophilia occurs when the body's immune system attacks and disables a certain protein that helps the blood clot. About half of the cases are associated with other conditions, such as pregnancy, autoimmune disease, cancer, skin diseases, or allergic reactions to medications."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 3,
  "parents": [
    {
      "id": 4360,
      "label": "hemorrhagic disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7217
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2213",
          "ICD9:287.9",
          "MEDGEN:6799",
          "MESH:D006474",
          "NCIT:C115221",
          "UMLS:C0019087"
        ],
        "synonyms": [
          "bleeding diathesis",
          "bleeding disorder",
          "bleeding predisposition",
          "bleeding tendency"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "Spontaneous or near spontaneous bleeding caused by a defect in clotting mechanisms (blood coagulation disorders) or another abnormality causing a structural flaw in the blood vessels (hemostatic disorders)."
      },
      "child_count": 28,
      "reference_id": "MONDO:0002243"
    },
    {
      "id": 18652,
      "label": "hemophilia",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4359
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0061030",
          "GARD:0010418",
          "MEDGEN:146334",
          "MedDRA:10061992",
          "NCIT:C3093",
          "Orphanet:448",
          "SCTID:90935002",
          "UMLS:C0684275"
        ],
        "synonyms": [
          "hemophilia"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "Hemophilia is a genetic disorder characterized by spontaneous hemorrhage or prolonged bleeding due to factor VIII or IX deficiency."
      },
      "child_count": 4,
      "reference_id": "MONDO:0018660"
    },
    {
      "id": 20034,
      "label": "acquired coagulation factor deficiency",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4359
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0025183",
          "ICD10CM:D68.4",
          "MEDGEN:98",
          "NANDO:1200896",
          "NCIT:C34347",
          "SCTID:25904003",
          "UMLS:C0001169"
        ],
        "synonyms": [
          "acquired coagulation factor deficiency",
          "acquired coagulation protein disease"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "Deficiency of a coagulation factor that is not caused by genetic alterations. Causes include vitamin K deficiency, amyloidosis, and severe liver disease."
      },
      "child_count": 6,
      "reference_id": "MONDO:0020599"
    }
  ],
  "children": [
    {
      "id": 22897,
      "label": "acquired hemophilia A",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        19017
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0006405",
          "MEDGEN:124426",
          "MESH:C536392",
          "NCIT:C35345",
          "Orphanet:599480",
          "UMLS:C0272325"
        ],
        "synonyms": [
          "AHA"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "An acquired form of hemophilia A, resulting in spontaneous bleeding in individuals with no history of bleeding disorders. It is believed to be caused by spontaneous inhibition of clotting factor VIII by autoantibodies, and is usually associated with other autoimmune conditions."
      },
      "child_count": 0,
      "reference_id": "MONDO:0035735"
    },
    {
      "id": 22898,
      "label": "acquired hemophilia B",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        19017
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0022407",
          "MEDGEN:98305",
          "Orphanet:599485",
          "UMLS:C0398609"
        ],
        "synonyms": [
          "AHB"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0035736"
    },
    {
      "id": 22901,
      "label": "acquired factor XI deficiency",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        19017,
        20024
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0022411",
          "MEDGEN:1376431",
          "NCIT:C131627",
          "Orphanet:599507",
          "UMLS:C4329257"
        ],
        "synonyms": [
          "aFXI"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0035740"
    }
  ],
  "roots": [
    {
      "id": 4360,
      "label": "hemorrhagic disease"
    },
    {
      "id": 18652,
      "label": "hemophilia"
    },
    {
      "id": 20034,
      "label": "acquired coagulation factor deficiency"
    }
  ]
}