{
  "id": 19041,
  "label": "central precocious puberty",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0019165",
  "properties": {
    "xrefs": [
      "DOID:0112308",
      "EFO:0009029",
      "GARD:0016546",
      "ICD9:259.1",
      "MEDGEN:90985",
      "MESH:C562787",
      "NANDO:1200381",
      "NANDO:2200377",
      "OMIMPS:176400",
      "Orphanet:650063",
      "Orphanet:759",
      "SCTID:237816004",
      "UMLS:C0342543",
      "icd11.foundation:1749914533"
    ],
    "synonyms": [
      "gonadotropin-dependant precocious puberty",
      "gonadotropin-dependent precocious puberty",
      "precocious puberty, central"
    ],
    "categories": [
      {
        "ref": "MONDO:0005039",
        "name": "reproductive system disorder"
      },
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "Central precocious puberty (CPP), also referred to as gonadotropin dependent precocious puberty, is an endocrine-related developmental disease characterized by the onset of pubertal changes, with development of secondary sexual characteristics and accelerated growth and bone maturation, before the normal age of puberty (8 years in girls and 9 years in boys)."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 7,
  "parents": [
    {
      "id": 2721,
      "label": "precocious puberty",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4375,
        20383
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "HP:0000826",
          "ICD10CM:E30.1",
          "ICD9:259.1",
          "MEDGEN:18752",
          "MESH:D011629",
          "MedDRA:10044701",
          "MedDRA:10058084",
          "NANDO:2100135",
          "NCIT:C79704",
          "Orphanet:95708",
          "SCTID:400179000",
          "UMLS:C0034013"
        ],
        "synonyms": [
          "pubertas praecox",
          "sexual precocity",
          "familial precocious puberty",
          "idiopathic sexual precocity"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "Unusually early sexual maturity."
      },
      "child_count": 6,
      "reference_id": "MONDO:0000088"
    },
    {
      "id": 5714,
      "label": "hereditary disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        29382
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:630",
          "EFO:0000508",
          "ICD9:799.89",
          "MEDGEN:5527",
          "MESH:D030342",
          "NCIT:C3101",
          "SCTID:32895009",
          "UMLS:C0019247"
        ],
        "synonyms": [
          "genetic condition",
          "genetic disease",
          "genetic disorder",
          "hereditary disease",
          "hereditary disease or disorder",
          "hereditary diseases",
          "inherited disease",
          "inherited genetic disease",
          "molecular disease",
          "Mendelian disease",
          "familial disorder",
          "inborn disorder"
        ],
        "definition": "A disease that is caused by genetic modifications where those modifications are inherited from a parent's genome."
      },
      "child_count": 1925,
      "reference_id": "MONDO:0003847"
    }
  ],
  "children": [
    {
      "id": 9608,
      "label": "central precocious puberty 1",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        19041
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0112310",
          "GARD:0024615",
          "MEDGEN:812209",
          "OMIM:176400",
          "UMLS:C3805879"
        ],
        "synonyms": [
          "KISS1R central precocious puberty",
          "central precocious puberty caused by mutation in KISS1R",
          "precocious puberty, central, 1",
          "precocious puberty, central, type 1",
          "CPPB1"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "Any central precocious puberty in which the cause of the disease is a mutation in the KISS1R gene."
      },
      "child_count": 0,
      "reference_id": "MONDO:0008302"
    },
    {
      "id": 15144,
      "label": "precocious puberty, central, 2",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        19041
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0112309",
          "GARD:0024975",
          "MEDGEN:815529",
          "OMIM:615346",
          "UMLS:C3809199"
        ],
        "synonyms": [
          "MKRN3 central precocious puberty",
          "central precocious puberty caused by mutation in MKRN3",
          "precocious puberty, central, 2",
          "precocious puberty, central, type 2",
          "CPPB2"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "Any central precocious puberty in which the cause of the disease is a mutation in the MKRN3 gene."
      },
      "child_count": 0,
      "reference_id": "MONDO:0014137"
    },
    {
      "id": 16473,
      "label": "idiopathic central precocious puberty",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        19041,
        24405
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "ICD9:259.1",
          "MEDGEN:575094",
          "NCIT:C120372",
          "Orphanet:169615",
          "SCTID:237817008",
          "UMLS:C0342544"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0015713"
    },
    {
      "id": 16474,
      "label": "secondary central precocious puberty",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        19041
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0027865",
          "Orphanet:169618"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0015714"
    },
    {
      "id": 25910,
      "label": "central precocious puberty in male",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        19041
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0026999",
          "MEDGEN:1853132",
          "Orphanet:649929",
          "UMLS:C5816736"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ]
      },
      "child_count": 2,
      "reference_id": "MONDO:0958270"
    },
    {
      "id": 25951,
      "label": "genetic central precocious puberty in female",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        19041
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0027028",
          "MEDGEN:1853156",
          "Orphanet:650077",
          "UMLS:C5816765"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0958354"
    },
    {
      "id": 25952,
      "label": "secondary central precocious puberty in female",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        19041
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0027029",
          "MEDGEN:1853148",
          "Orphanet:650082",
          "UMLS:C5816762"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0958355"
    }
  ],
  "roots": [
    {
      "id": 2721,
      "label": "precocious puberty"
    },
    {
      "id": 5714,
      "label": "hereditary disease"
    }
  ]
}