{
  "id": 19055,
  "label": "inherited obesity",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0019182",
  "properties": {
    "xrefs": [
      "GARD:0018935",
      "MEDGEN:885912",
      "OMIM:601665",
      "Orphanet:77828",
      "UMLS:C4054476"
    ],
    "synonyms": [
      "genetic obesity",
      "genetic obesity (disease)",
      "leanness, inherited, autosomal recessive",
      "monogenic obesity",
      "obesity, association with, Autosomal recessive",
      "obesity, early-onset, susceptibility to, Autosomal recessive",
      "obesity, late-onset, Autosomal recessive",
      "obesity, mild, early-onset, Autosomal recessive",
      "obesity, severe, Autosomal recessive",
      "obesity, severe, and type II diabetes, Autosomal recessive",
      "obesity, susceptibility to, Autosomal recessive"
    ],
    "categories": [
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ]
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 7,
  "parents": [
    {
      "id": 5714,
      "label": "hereditary disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        29382
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:630",
          "EFO:0000508",
          "ICD9:799.89",
          "MEDGEN:5527",
          "MESH:D030342",
          "NCIT:C3101",
          "SCTID:32895009",
          "UMLS:C0019247"
        ],
        "synonyms": [
          "genetic condition",
          "genetic disease",
          "genetic disorder",
          "hereditary disease",
          "hereditary disease or disorder",
          "hereditary diseases",
          "inherited disease",
          "inherited genetic disease",
          "molecular disease",
          "Mendelian disease",
          "familial disorder",
          "inborn disorder"
        ],
        "definition": "A disease that is caused by genetic modifications where those modifications are inherited from a parent's genome."
      },
      "child_count": 1925,
      "reference_id": "MONDO:0003847"
    },
    {
      "id": 6875,
      "label": "endocrine system disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        29379
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:28",
          "EFO:0001379",
          "ICD9:259.8",
          "ICD9:259.9",
          "MEDGEN:4043",
          "MESH:D004700",
          "NANDO:1100009",
          "NANDO:2100109",
          "NCIT:C3009",
          "SCTID:362969004",
          "UMLS:C0014130"
        ],
        "synonyms": [
          "disease of endocrine system",
          "disease or disorder of endocrine system",
          "disorder of endocrine system",
          "endocrine disease",
          "endocrine disorder",
          "endocrine system disease",
          "endocrine system disease or disorder",
          "endocrine system disorder",
          "endocrinopathy",
          "thyroid or other glandular disorders"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A disease involving the endocrine system."
      },
      "child_count": 48,
      "reference_id": "MONDO:0005151"
    },
    {
      "id": 12246,
      "label": "obesity disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5777
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:9970",
          "EFO:0001073",
          "HP:0001513",
          "ICD9:278.0",
          "ICD9:278.00",
          "MEDGEN:18127",
          "NCIT:C3283",
          "Orphanet:521399",
          "SCTID:414916001",
          "UMLS:C0028754"
        ],
        "synonyms": [
          "obesity",
          "obesity disease"
        ],
        "definition": "A disorder involving an excessive amount of body fat."
      },
      "child_count": 2,
      "reference_id": "MONDO:0011122"
    }
  ],
  "children": [
    {
      "id": 12090,
      "label": "obesity due to prohormone convertase I deficiency",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        16526,
        19055
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0111698",
          "GARD:0016689",
          "MEDGEN:318777",
          "MESH:C563423",
          "NORD:109523",
          "OMIM:600955",
          "Orphanet:71528",
          "SCTID:722053001",
          "UMLS:C1833053"
        ],
        "synonyms": [
          "PCI deficiency",
          "PCSK1 Deficiency",
          "obesity and endocrinopathy due to impaired processing of prohormones",
          "proprotein convertase 1/3 deficiency"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "Prohormone convertase-I deficiency is the rarest form of monogenic obesity. The disorder is characterized by severe childhood obesity, hypoadrenalism, reactive hypoglycaemia, and elevated circulating levels of certain prohormones."
      },
      "child_count": 0,
      "reference_id": "MONDO:0010961"
    },
    {
      "id": 13390,
      "label": "obesity due to pro-opiomelanocortin deficiency",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        19055
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0010823",
          "ICD9:255.5",
          "MEDGEN:341863",
          "MESH:C565726",
          "NORD:110450",
          "OMIM:609734",
          "Orphanet:71526",
          "SCTID:702949005",
          "UMLS:C1857854",
          "icd11.foundation:530374033"
        ],
        "synonyms": [
          "POMC Deficiency",
          "POMC deficiency",
          "obesity, adrenal insufficiency, and red hair due to POMC deficiency",
          "OBAIRH",
          "PROOPIOMELANOCORTIN deficiency",
          "obesity, early-onset, adrenal insufficiency, and Red hair",
          "obesity, early-onset, with adrenal insufficiency and RED hair",
          "obesity, early-onset, with adrenal insufficiency and Red hair"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "Pro-opiomelanocortin (POMC) deficiency is a form of monogenic obesity resulting in severe early-onset obesity, adrenal insufficiency, red hair and pale skin."
      },
      "child_count": 0,
      "reference_id": "MONDO:0012335"
    },
    {
      "id": 15001,
      "label": "obesity due to congenital leptin deficiency",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        16526,
        19055
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0111334",
          "GARD:0013015",
          "MEDGEN:767138",
          "NORD:110641",
          "OMIM:614962",
          "Orphanet:66628",
          "UMLS:C3554224",
          "icd11.foundation:591009309"
        ],
        "synonyms": [
          "Congenital Leptin Deficiency",
          "obesity, morbid, due to leptin deficiency",
          "LEPD",
          "leptin deficiency or dysfunction",
          "obesity, morbid, nonsyndromic 1"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "Congenital leptin deficiency is a form of monogenic obesity characterized by severe early-onset obesity and marked hyperphagia."
      },
      "child_count": 0,
      "reference_id": "MONDO:0013991"
    },
    {
      "id": 15002,
      "label": "obesity due to leptin receptor gene deficiency",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        16526,
        19055
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0017083",
          "MEDGEN:767139",
          "NCIT:C120386",
          "NORD:109401",
          "OMIM:614963",
          "Orphanet:179494",
          "UMLS:C3554225",
          "icd11.foundation:997823205"
        ],
        "synonyms": [
          "LEPR Deficiency",
          "obesity due to leptin receptor gene deficiency",
          "obesity, morbid, due to leptin receptor deficiency",
          "leptin receptor deficiency",
          "obesity, morbid, nonsyndromic 2"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0013992"
    },
    {
      "id": 15313,
      "label": "obesity due to CEP19 deficiency",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        19055
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0017631",
          "MEDGEN:816654",
          "OMIM:615703",
          "Orphanet:397615",
          "UMLS:C3810324"
        ],
        "synonyms": [
          "MOSPGF",
          "morbid obesity and spermatogenic failure"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0014309"
    },
    {
      "id": 18367,
      "label": "obesity due to SIM1 deficiency",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        19055
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0021580",
          "MEDGEN:1680592",
          "Orphanet:369873",
          "UMLS:C5191050"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0018244"
    },
    {
      "id": 18999,
      "label": "obesity due to melanocortin 4 receptor deficiency",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        19055
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0016690",
          "MEDGEN:903905",
          "NCIT:C120394",
          "Orphanet:71529",
          "SCTID:717269008",
          "UMLS:C4273958"
        ],
        "synonyms": [
          "MC4R deficiency"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "Melanocortin 4 receptor (MC4R) deficiency is the commonest form of monogenic obesity identified so far. MC4R deficiency is characterized by severe obesity, an increase in lean body mass and bone mineral density, increased linear growth in early childhood, hyperphagia beginning in the first year of life and severe hyperinsulinaemia, in the presence of preserved reproductive function."
      },
      "child_count": 0,
      "reference_id": "MONDO:0019115"
    }
  ],
  "roots": [
    {
      "id": 5714,
      "label": "hereditary disease"
    },
    {
      "id": 6875,
      "label": "endocrine system disorder"
    },
    {
      "id": 12246,
      "label": "obesity disorder"
    }
  ]
}