{
  "id": 19061,
  "label": "IgG4-related dacryoadenitis and sialadenitis",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0019191",
  "properties": {
    "xrefs": [
      "DOID:12900",
      "GARD:0007043",
      "MEDGEN:6399",
      "MESH:D008882",
      "MedDRA:10051457",
      "MedDRA:10052317",
      "NANDO:1200929",
      "NCIT:C34819",
      "Orphanet:79078",
      "SCTID:7826003",
      "UMLS:C0026103",
      "icd11.foundation:796087277"
    ],
    "synonyms": [
      "Mikulicz disease",
      "chronic dacryoadenitis and sialadenitis",
      "Mikulicz disease (former)",
      "Mikulicz syndrome (former)",
      "Mikulicz's disease (former)"
    ],
    "categories": [
      {
        "ref": "MONDO:0002022",
        "name": "disorder of orbital region"
      },
      {
        "ref": "MONDO:0005046",
        "name": "immune system disorder"
      },
      {
        "ref": "MONDO:0024458",
        "name": "disorder of visual system"
      },
      {
        "ref": "MONDO:0024623",
        "name": "otorhinolaryngologic disease"
      }
    ],
    "definition": "IgG4-related dacryoadenitis and sialoadenitis (Mikulicz disease) is an IgG4-related sclerosing disease characterized by persistent, usually painless, bilateral enlargement of the lacrimal, parotid, and submandibular glands associated with elevated levels of serum immunoglobulin (Ig) G4 and with lymphocyte and IgG4-positive plasmacyte infiltration. It predominantly causes mouth and eye dryness but can also affect other organs such as the lungs, liver, and kidneys, and be accompanied by complications such as autoimmune pancreatitis (AIP), retroperitoneal fibrosis, and tubulointerstitial nephritis."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 3003,
      "label": "autoimmune disease of ear, nose and throat",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        8586,
        21538
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0060030"
        ],
        "synonyms": [
          "autoimmune otorhinolaryngologic disease",
          "autoimmune disease of eyes, ear, nose and throat"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0024623",
            "name": "otorhinolaryngologic disease"
          }
        ],
        "definition": "An autoimmune form of otorhinolaryngologic disease."
      },
      "child_count": 14,
      "reference_id": "MONDO:0000587"
    },
    {
      "id": 4032,
      "label": "lacrimal apparatus disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        2924,
        7019
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1400",
          "EFO:0009455",
          "ICD9:375",
          "ICD9:375.69",
          "ICD9:375.89",
          "ICD9:375.9",
          "MEDGEN:5994",
          "MESH:D007766",
          "NCIT:C26809",
          "SCTID:31053003",
          "UMLS:C0022904"
        ],
        "synonyms": [
          "disease of lacrimal apparatus",
          "disease or disorder of lacrimal apparatus",
          "disorder of lacrimal apparatus",
          "disorder of lacrimal system",
          "lacrimal apparatus disease",
          "lacrimal apparatus disease or disorder",
          "lacrimal system disease",
          "lacrimal system disorder",
          "lachrymal system disorders"
        ],
        "categories": [
          {
            "ref": "MONDO:0002022",
            "name": "disorder of orbital region"
          },
          {
            "ref": "MONDO:0024458",
            "name": "disorder of visual system"
          }
        ],
        "definition": "A non-neoplastic or neoplastic disorder that affects the lacrimal apparatus."
      },
      "child_count": 34,
      "reference_id": "MONDO:0001854"
    },
    {
      "id": 18666,
      "label": "IgG4-related ophthalmic disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7019,
        17611
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0021885",
          "MEDGEN:1800432",
          "Orphanet:449563",
          "UMLS:C5569009"
        ],
        "synonyms": [
          "IgG4-related disease of eye",
          "eye IgG4-related disease"
        ],
        "categories": [
          {
            "ref": "MONDO:0002022",
            "name": "disorder of orbital region"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0024458",
            "name": "disorder of visual system"
          }
        ],
        "definition": "A IgG4-related disease that involves the eye."
      },
      "child_count": 2,
      "reference_id": "MONDO:0018675"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 3003,
      "label": "autoimmune disease of ear, nose and throat"
    },
    {
      "id": 4032,
      "label": "lacrimal apparatus disorder"
    },
    {
      "id": 18666,
      "label": "IgG4-related ophthalmic disorder"
    }
  ]
}