{
  "id": 19064,
  "label": "localized lipodystrophy",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0019194",
  "properties": {
    "xrefs": [
      "GARD:0005867",
      "MEDGEN:1385527",
      "NCIT:C131814",
      "Orphanet:79088",
      "UMLS:C4329999"
    ],
    "synonyms": [
      "focal lipodystrophy",
      "centrifugal lipodystrophy (subtype)",
      "drug-induced localised lipodystrophy (subtype)",
      "drug-induced localized lipodystrophy (subtype)",
      "idiopathic localised lipodystrophy (subtype)",
      "idiopathic localized lipodystrophy (subtype)",
      "panniculitis and localised lipodystrophy (subtype)",
      "panniculitis and localized lipodystrophy (subtype)",
      "pressure-induced localised lipoatrophy (subtype)",
      "pressure-induced localized lipoatrophy (subtype)"
    ],
    "categories": [
      {
        "ref": "MONDO:0002051",
        "name": "integumentary system disorder"
      }
    ],
    "definition": "Localised lipodystrophies are characterized by loss of subcutaneous tissue from small regions of the body."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 5,
  "parents": [
    {
      "id": 8053,
      "label": "lipodystrophy",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6795,
        6820
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:811",
          "EFO:1000727",
          "GARD:0027051",
          "HP:0009125",
          "ICD9:272.6",
          "MEDGEN:6111",
          "MESH:D008060",
          "NANDO:1200858",
          "NANDO:2100147",
          "NANDO:2200404",
          "NCIT:C97093",
          "SCTID:71325002",
          "UMLS:C0023787",
          "Wikipedia:Lipodystrophy"
        ],
        "synonyms": [
          "lipodsystrophic syndrome",
          "lipodsystrophic syndromes",
          "lipodystrophy",
          "lipodystrophy (disease)"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ],
        "definition": "A congenital or acquired disorder characterized by abnormal loss or redistribution of the adipose tissue in the body."
      },
      "child_count": 10,
      "reference_id": "MONDO:0006573"
    }
  ],
  "children": [
    {
      "id": 19359,
      "label": "centrifugal lipodystrophy",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        19064
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0019125",
          "MEDGEN:590539",
          "Orphanet:90156",
          "UMLS:C0406605",
          "icd11.foundation:1561732835"
        ],
        "synonyms": [
          "lipodystrophia centrifugalis abdominalis infantilis"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ],
        "definition": "Centrifugal lipodystrophy is a rare, acquired, localized lipodistrophy characterized by single or, occasionally, multiple, centrifugally progressive, asymptomatic to sometimes mildly tender, hypopigmented, lipoatrophic skin depressions with weakly erymatheous inflammatory borders, typically associated with regional ipsilateral lymph nodes swelling. Lesions typically occur on lower trunk (in particular groin and abdomen region), followed by upper trunk (axilla and neighboring regions) and, rarely, neck and head. It is usually not associated with systemic disease and is typically self-resolving."
      },
      "child_count": 0,
      "reference_id": "MONDO:0019552"
    },
    {
      "id": 19360,
      "label": "drug-induced localized lipodystrophy",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        19064
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0019126",
          "MEDGEN:698295",
          "Orphanet:90157",
          "SCTID:403661001",
          "UMLS:C1274983"
        ],
        "synonyms": [
          "lipoatrophy caused by injected drug"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ],
        "definition": "Drug-induced localized lipodystrophy is a rare, acquired, localized lipodystrophy characterized by the appearance of asymptomatic, well-demarcated, variably sized, depressed, lipoatrophic lesions secondary to subcutaneous, intradermic or intramuscular drug injection, including corticosteroids, insulin, human growth hormone and antibiotics. Skin coloration may vary from white or hypopigmented to reddish, pinkish or violaceous. Epidermal atrophy may be also present."
      },
      "child_count": 0,
      "reference_id": "MONDO:0019553"
    },
    {
      "id": 19361,
      "label": "idiopathic localized lipodystrophy",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        19064,
        24405
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0019127",
          "MEDGEN:633314",
          "Orphanet:90158",
          "UMLS:C0473566"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ],
        "definition": "Idiopathic localized lipodystrophy is a rare, acquired, localized lipodystrophy characterized by asymptomatic, well-demarcated, depressed, lipoatrophic lesions of variable size, with normal overlying skin without antecedent inflammation or a known identifiable cause (autoimmune disease, drug injection, injury, etc)."
      },
      "child_count": 0,
      "reference_id": "MONDO:0019554"
    },
    {
      "id": 19362,
      "label": "panniculitis and localized lipodystrophy",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        8067,
        19064
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0019128",
          "MEDGEN:1678538",
          "Orphanet:90159",
          "UMLS:C5190785"
        ],
        "synonyms": [
          "panniculitis-induced localised lipodystrophy",
          "panniculitis-induced localized lipodystrophy"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0019555"
    },
    {
      "id": 19363,
      "label": "pressure-induced localized lipoatrophy",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        19064
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0019129",
          "MEDGEN:687584",
          "Orphanet:90160",
          "SCTID:238898001",
          "UMLS:C1260961"
        ],
        "synonyms": [
          "lipoatrophia semicircularis",
          "semicircular lipoatrophy"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ],
        "definition": "Pressure-induced localized lipoatrophy is a rare, acquired, localized lipodystrophy characterized by band-like, horizontal, asymptomatic, lipoatrophic depressions with clinically normal overlying skin usually involving the anterolateral aspect of the thighs. An identifiable history of the repeated mechanical microtrauma due to occupational or postural habits is present."
      },
      "child_count": 0,
      "reference_id": "MONDO:0019556"
    }
  ],
  "roots": [
    {
      "id": 8053,
      "label": "lipodystrophy"
    }
  ]
}