{
  "id": 19079,
  "label": "cutaneous neuroendocrine carcinoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0019210",
  "properties": {
    "xrefs": [
      "GARD:0009266",
      "ICD10CM:C4A",
      "ICD9:209.36",
      "ICDO:8247/3",
      "MEDGEN:2843",
      "MESH:D015266",
      "NCIT:C9231",
      "NORD:1947",
      "ONCOTREE:MCC",
      "Orphanet:79140",
      "SCTID:253001006",
      "UMLS:C0007129",
      "icd11.foundation:680322043"
    ],
    "synonyms": [
      "MCC",
      "Merkel Cell Carcinoma",
      "Merkel cell cancer",
      "Merkel cell carcinoma",
      "Merkel cell tumor",
      "Merkel cell tumour",
      "carcinoma of Merkel cell",
      "cutaneous APUDoma",
      "cutaneous neuroendocrine carcinoma",
      "neuroendocrine carcinoma of skin",
      "neuroendocrine carcinoma of the skin",
      "neuroendocrine skin carcinoma",
      "trabecular cancer",
      "trabecular skin carcinoma",
      "Merkle tumors",
      "Merkle tumours",
      "carcinoma, Merkel cell"
    ],
    "categories": [
      {
        "ref": "MONDO:0002051",
        "name": "integumentary system disorder"
      },
      {
        "ref": "MONDO:0005071",
        "name": "nervous system disorder"
      },
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "Cutaneous neuroendocrine carcinoma is a primary cutaneous cancer arising from a subset of skin neuroendocrine cells (Merkel cells, giving the name Merkel cell carcinoma (MCC))."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 4255,
      "label": "neuroendocrine carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6734,
        19314,
        20310
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1800",
          "GARD:0023067",
          "ICDO:8246/3",
          "MEDGEN:104919",
          "MESH:D018278",
          "NCIT:C3773",
          "SCTID:253000007",
          "UMLS:C0206695"
        ],
        "synonyms": [
          "NEC",
          "neuroendocrine cancer",
          "neuroendocrine carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A malignant neuroendocrine neoplasm composed of cells containing secretory granules that stain positive for NSE and chromogranin. The neoplastic cells are often round and form clusters or trabecular sheets. Representative examples are small cell carcinoma, large cell neuroendocrine carcinoma, and Merkel cell carcinoma."
      },
      "child_count": 36,
      "reference_id": "MONDO:0002120"
    },
    {
      "id": 4707,
      "label": "skin carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4907,
        6734,
        20690
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3451",
          "EFO:0009259",
          "MEDGEN:195945",
          "NCIT:C4914",
          "UMLS:C0699893"
        ],
        "synonyms": [
          "carcinoma of skin",
          "carcinoma of the skin",
          "carcinoma of zone of skin",
          "non-melanoma cancer of skin",
          "non-melanoma cancer of the skin",
          "non-melanoma skin cancer",
          "nonmelanoma skin cancer",
          "skin cancer, non-melanoma",
          "skin carcinoma",
          "zone of skin carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ],
        "definition": "A carcinoma that arises from epithelial cells of the zone of skin"
      },
      "child_count": 39,
      "reference_id": "MONDO:0002656"
    },
    {
      "id": 5298,
      "label": "malignant dermis tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4409,
        4907
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5274",
          "GARD:0023477",
          "MEDGEN:87564",
          "NCIT:C4574",
          "SCTID:255096006",
          "UMLS:C0346811"
        ],
        "synonyms": [
          "cancer of dermis",
          "dermis cancer",
          "malignant dermal neoplasm",
          "malignant dermis neoplasm",
          "malignant dermis tumor",
          "malignant neoplasm of dermis",
          "malignant neoplasm of the dermis",
          "malignant tumor of dermis",
          "malignant tumor of the dermis",
          "malignant tumour of the dermis"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ],
        "definition": "A malignant neoplasm involving the dermis."
      },
      "child_count": 8,
      "reference_id": "MONDO:0003363"
    },
    {
      "id": 7479,
      "label": "nervous system cancer",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6733,
        20456
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3093",
          "EFO:0007392",
          "ICD9:192",
          "ICD9:192.8",
          "ICD9:192.9",
          "MEDGEN:99231",
          "MESH:D009423",
          "NCIT:C4788",
          "SCTID:372063002",
          "UMLS:C0497549"
        ],
        "synonyms": [
          "nervous system neoplasm",
          "neural neoplasm",
          "neural tumor",
          "neural tumour",
          "tumor of the nervous system",
          "tumour of the nervous system",
          "cancer of nervous system",
          "malignant neoplasm of nervous system",
          "malignant neoplasm of the nervous system",
          "malignant nervous system neoplasm",
          "malignant nervous system tumor",
          "malignant nervous system tumour",
          "malignant tumor of nervous system",
          "malignant tumor of the nervous system",
          "malignant tumour of nervous system",
          "malignant tumour of the nervous system",
          "nervous system cancer",
          "nervous system neoplasms, malignant"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A primary or metastatic malignant neoplasm involving the nervous system."
      },
      "child_count": 12,
      "reference_id": "MONDO:0005872"
    },
    {
      "id": 17658,
      "label": "virus associated tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6798,
        20721
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:1842723",
          "Orphanet:289635",
          "UMLS:C5681008"
        ]
      },
      "child_count": 16,
      "reference_id": "MONDO:0017341"
    },
    {
      "id": 20691,
      "label": "neurocristopathy",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        20383
      ],
      "type_id": 0,
      "properties": {
        "synonyms": [
          "disorder of neural crest cell development",
          "disorder of neural crest development",
          "neural crest cell development disease"
        ],
        "definition": "That disease that arises from defects in the development of tissues containing cells commonly derived from the embryonic neural crest cell lineage."
      },
      "child_count": 16,
      "reference_id": "MONDO:0021635"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 4255,
      "label": "neuroendocrine carcinoma"
    },
    {
      "id": 4707,
      "label": "skin carcinoma"
    },
    {
      "id": 5298,
      "label": "malignant dermis tumor"
    },
    {
      "id": 7479,
      "label": "nervous system cancer"
    },
    {
      "id": 17658,
      "label": "virus associated tumor"
    },
    {
      "id": 20691,
      "label": "neurocristopathy"
    }
  ]
}