{
  "id": 19132,
  "label": "hereditary palmoplantar keratoderma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0019272",
  "properties": {
    "xrefs": [
      "GARD:0018988",
      "ICD9:757.39",
      "MEDGEN:590657",
      "Orphanet:79357",
      "SCTID:239066003",
      "UMLS:C0406757",
      "icd11.foundation:1941547119"
    ],
    "synonyms": [
      "hereditary PPK",
      "hereditary keratosis palmoplantaris",
      "hereditary palmoplantar hyperkeratosis",
      "hereditary palmoplantar keratosis"
    ],
    "categories": [
      {
        "ref": "MONDO:0002051",
        "name": "integumentary system disorder"
      }
    ],
    "definition": "An instance of palmoplantar keratosis that is caused by an inherited modification of the individual's genome."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 8,
  "parents": [
    {
      "id": 8066,
      "label": "palmoplantar keratosis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        8047
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3390",
          "EFO:1000745",
          "ICD9:757.39",
          "MEDGEN:44017",
          "NCIT:C34748",
          "SCTID:706885006",
          "UMLS:C0022596"
        ],
        "synonyms": [
          "palmoplantar keratoderma",
          "keratoderma, palmoplantar"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ],
        "definition": "A group of autosomal dominant, autosomal recessive, X-linked inherited or acquired disorders characterized by the thickening of the palms and soles due to hyperkeratosis."
      },
      "child_count": 2,
      "reference_id": "MONDO:0006590"
    },
    {
      "id": 19129,
      "label": "epidermal disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6820
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:1842776",
          "Orphanet:79353",
          "UMLS:C5681492"
        ],
        "synonyms": [
          "epidermal disease",
          "rare epidermal disease"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ],
        "definition": "A skin disease that involves the epidermis."
      },
      "child_count": 25,
      "reference_id": "MONDO:0019268"
    },
    {
      "id": 23867,
      "label": "hereditary skin disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5714,
        6820
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MESH:D012873",
          "SCTID:239001006"
        ],
        "synonyms": [
          "disease, genetic skin",
          "diseases, genetic skin",
          "genetic skin disease",
          "genetic skin diseases",
          "genodermatosis",
          "skin disease, genetic"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ],
        "definition": "An instance of skin disease that is caused by a modification of the individual's genome."
      },
      "child_count": 228,
      "reference_id": "MONDO:0100118"
    }
  ],
  "children": [
    {
      "id": 9195,
      "label": "palmoplantar keratoderma i, striate, focal, or diffuse",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        19132
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0081108",
          "GARD:0009172",
          "MEDGEN:419717",
          "MESH:C536162",
          "OMIM:148700",
          "UMLS:C2931122"
        ],
        "synonyms": [
          "keratosis palmoplantaris striata i, AD",
          "palmoplantar keratoderma i, striate, focal, or diffuse",
          "PPKS1",
          "SPPK1",
          "keratoderma, palmoplantar striate form 1",
          "keratoderma, palmoplantar, striate form 1",
          "keratosis palmoplantaris striata 1",
          "palmoplantar keratoderma I, striate, focal, or diffuse",
          "striate palmoplantar keratoderma 1"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0007859"
    },
    {
      "id": 15330,
      "label": "palmoplantar keratoderma, nonepidermolytic, focal or diffuse",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        19132
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0111710",
          "GARD:0017669",
          "MEDGEN:816724",
          "OMIM:615735",
          "Orphanet:402003",
          "UMLS:C3810394"
        ],
        "synonyms": [
          "autosomal dominant focal non-epidermolytic palmoplantar keratoderma with plantar blistering",
          "palmoplantar keratoderma, nonepidermolytic, focal or diffuse",
          "PPKNEFD"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0014327"
    },
    {
      "id": 17917,
      "label": "diffuse palmoplantar keratoderma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        19132
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0021289",
          "HP:0007435",
          "ICD9:757.39",
          "MEDGEN:7201",
          "Orphanet:307141",
          "SCTID:400123002",
          "UMLS:C0022584",
          "icd11.foundation:1259583500"
        ],
        "synonyms": [
          "diffuse PPK",
          "diffuse keratosis palmoplantaris",
          "diffuse palmoplantar hyperkeratosis"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ],
        "definition": "Palmoplantar keratoderma that diffusely involves most of the palm and sole and is caused by a genetic abnormality."
      },
      "child_count": 32,
      "reference_id": "MONDO:0017666"
    },
    {
      "id": 17919,
      "label": "focal palmoplantar keratoderma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        19132
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0021294",
          "MEDGEN:419939",
          "Orphanet:307837",
          "UMLS:C2931923",
          "icd11.foundation:1676945961"
        ],
        "synonyms": [
          "focal PPK",
          "focal keratosis palmoplantaris",
          "focal palmoplantar hyperkeratosis"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ]
      },
      "child_count": 12,
      "reference_id": "MONDO:0017672"
    },
    {
      "id": 17920,
      "label": "punctate palmoplantar keratoderma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        19132
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0060361",
          "GARD:0021297",
          "MEDGEN:870406",
          "Orphanet:307967",
          "SCTID:402773000",
          "UMLS:C4024851",
          "icd11.foundation:1212361548"
        ],
        "synonyms": [
          "punctate PPK",
          "punctate keratosis palmoplantaris",
          "punctate palmoplantar hyperkeratosis"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ],
        "definition": "A palmoplantar keratosis characterized by keratoses with a \"raindrop\" pattern on the palmoplantar surface, skin lesions which may involve the whole of the palmoplantar surface, or may be more restricted in their distribution."
      },
      "child_count": 4,
      "reference_id": "MONDO:0017675"
    },
    {
      "id": 20853,
      "label": "alopecia congenita keratosis palmoplantaris",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4370,
        19132
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0025361",
          "MEDGEN:354901",
          "MESH:C537050",
          "UMLS:C1863093"
        ],
        "synonyms": [
          "alopecia congenita with hyperkeratosis of the palms and soles",
          "alopecia congenita with keratosis palmoplantaris"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0022417"
    },
    {
      "id": 22242,
      "label": "Olmsted syndrome",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        19132
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0112011",
          "GARD:0004075",
          "MEDGEN:590661",
          "MedDRA:10068842",
          "OMIMPS:614594",
          "Orphanet:659",
          "UMLS:C0406761"
        ],
        "synonyms": [
          "mutilating palmoplantar hyperkeratosis with periorificial keratotic plaques",
          "palmoplantar and periorificial keratoderma",
          "palmoplantar keratoderma, mutilating, with periorificial keratotic plaques"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ],
        "definition": "A hereditary palmoplantar keratoderma characterized by the combination of bilateral mutilating transgredient palmoplantar keratoderma and periorificial keratotic plaques."
      },
      "child_count": 3,
      "reference_id": "MONDO:0031421"
    },
    {
      "id": 25959,
      "label": "palmoplantar keratoderma, epidermolytic",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        19132
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0080223",
          "GARD:0027034",
          "MEDGEN:354561",
          "OMIMPS:144200",
          "UMLS:C1721006"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ]
      },
      "child_count": 2,
      "reference_id": "MONDO:0968949"
    }
  ],
  "roots": [
    {
      "id": 8066,
      "label": "palmoplantar keratosis"
    },
    {
      "id": 19129,
      "label": "epidermal disease"
    },
    {
      "id": 23867,
      "label": "hereditary skin disorder"
    }
  ]
}