{
  "id": 19134,
  "label": "hair anomaly",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0019278",
  "properties": {
    "xrefs": [
      "MEDGEN:539624",
      "Orphanet:79363",
      "UMLS:C0265991"
    ],
    "categories": [
      {
        "ref": "MONDO:0002051",
        "name": "integumentary system disorder"
      }
    ]
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 8,
  "parents": [
    {
      "id": 4924,
      "label": "disorder of pilosebaceous unit",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4198
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:421",
          "ICD9:704.8",
          "ICD9:704.9",
          "MEDGEN:640417",
          "MESH:D006201",
          "NCIT:C34656",
          "SCTID:201128002",
          "UMLS:C0554472"
        ],
        "synonyms": [
          "disease of pilosebaceous unit",
          "disease or disorder of pilosebaceous unit",
          "disorder of pilosebaceous unit",
          "hair and hair follicle diseases",
          "hair disorder",
          "hair/hair follicle diseases",
          "pilosebaceous unit disease",
          "pilosebaceous unit disease or disorder",
          "hair disease"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ],
        "definition": "A disease that involves the pilosebaceous unit."
      },
      "child_count": 9,
      "reference_id": "MONDO:0002917"
    },
    {
      "id": 21436,
      "label": "skin appendage disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4198
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "ICD10CM:L60-L75",
          "MEDGEN:508145",
          "SCTID:238714008",
          "UMLS:C0037272"
        ],
        "synonyms": [
          "cutaneous appendage disease",
          "cutaneous appendage disease or disorder",
          "disease of cutaneous appendage",
          "disease or disorder of cutaneous appendage",
          "disorder of cutaneous appendage",
          "disorder of skin appendage",
          "disease of epidermal appendage",
          "disease of epidermal appendages"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ],
        "definition": "A disease that involves the cutaneous appendage."
      },
      "child_count": 4,
      "reference_id": "MONDO:0024481"
    }
  ],
  "children": [
    {
      "id": 6660,
      "label": "alopecia",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        19134
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:987",
          "ICD9:704.0",
          "ICD9:704.00",
          "ICD9:704.09",
          "MEDGEN:7982",
          "MESH:D000505",
          "NCIT:C50575",
          "Orphanet:79364",
          "SCTID:56317004",
          "UMLS:C0002170",
          "icd11.foundation:1313926062"
        ],
        "synonyms": [
          "alopecia",
          "hair loss",
          "loss Of hair",
          "alopecia areata"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ],
        "definition": "Hair loss usually from the scalp. It may result in bald spots or spread to the entire scalp or the entire epidermis. It may be androgenetic or caused by chemotherapeutic agents, compulsive hair pulling, autoimmune disorders or congenital conditions."
      },
      "child_count": 26,
      "reference_id": "MONDO:0004907"
    },
    {
      "id": 9687,
      "label": "ringed hair disease",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        19134
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0004359",
          "MEDGEN:75523",
          "MESH:C537187",
          "OMIM:180600",
          "Orphanet:169",
          "SCTID:21926007",
          "UMLS:C0263489"
        ],
        "synonyms": [
          "pili annulati",
          "ringed hair"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ],
        "definition": "Pili annulati is an isolated, benign hair shaft abnormality, usually presenting after the age of 2 and affecting the hair of the scalp or very rarely beard, axillary, or pubic hair, that is characterized by a banded or speckled appearance due to alternating light bands (corresponding to air-filled cavities within the cortex of the affected hair shafts) and dark bands. The bands have a lifelong duration, may only be detectable under light microscopy, are more apparent in fair-colored hair or with age-related graying, and have no effect on hair growth or fragility in the vast majority of cases."
      },
      "child_count": 0,
      "reference_id": "MONDO:0008388"
    },
    {
      "id": 9883,
      "label": "trichodysplasia-xeroderma syndrome",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        19134
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0005261",
          "MEDGEN:349898",
          "MESH:C566032",
          "OMIM:190360",
          "Orphanet:3361",
          "UMLS:C1860822"
        ],
        "synonyms": [
          "trichodysplasia xeroderma",
          "trichodysplasia-xeroderma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ],
        "definition": "Trichodysplasia-xeroderma syndrome is an extremely rare, syndromic hair shaft anomaly characterized by sparse, coarse, brittle, excessively dry and slow-growing scalp hair, sparse axillary and pubic hair, sparse or absent eyelashes and eyebrows and dry skin. Hair shaft analysis shows pili torti, longitudinal splitting, grooves, peeling and scaling. There have been no further descriptions in the literature since 1987."
      },
      "child_count": 0,
      "reference_id": "MONDO:0008598"
    },
    {
      "id": 9905,
      "label": "uncombable hair syndrome",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        19134
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0005404",
          "MEDGEN:96596",
          "MESH:C536939",
          "Orphanet:1410",
          "SCTID:254230001",
          "UMLS:C0432347",
          "icd11.foundation:244892708"
        ],
        "synonyms": [
          "pili trianguli et canaliculi",
          "uncombable hair syndrome",
          "cheveux incoiffables",
          "spun glass hair",
          "unmanageable hair syndrome"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ],
        "definition": "Uncombable hair syndrome (UHS), or pili trianguli et canaliculi, is a rare scalp hair shaft dysplasia."
      },
      "child_count": 3,
      "reference_id": "MONDO:0008621"
    },
    {
      "id": 9961,
      "label": "isolated familial wooly hair disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        19134
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0111572",
          "GARD:0005597",
          "HP:0002224",
          "MEDGEN:87469",
          "MESH:C536745",
          "MedDRA:10048017",
          "Orphanet:170",
          "SCTID:52564001",
          "UMLS:C0343073"
        ],
        "synonyms": [
          "familial woolly hair syndrome",
          "familial wooly hair syndrome",
          "hereditary woolly hair syndrome",
          "hereditary wooly hair syndrome",
          "woolly hair",
          "wooly hair",
          "ADWH",
          "familial woolly hair (autosomal recessive)",
          "familial wooly hair (autosomal recessive)",
          "hereditary woolly hair (autosomal dominant)",
          "hereditary wooly hair (autosomal dominant)",
          "woolly hair syndrome",
          "woolly hair, autosomal dominant",
          "wooly hair syndrome",
          "wooly hair, autosomal dominant"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ],
        "definition": "Woolly hair is a rare congenital abnormality of the structure of the scalp hair marked by extreme kinkiness of the hair."
      },
      "child_count": 6,
      "reference_id": "MONDO:0008686"
    },
    {
      "id": 11073,
      "label": "pili torti",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        19134
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0004361",
          "HP:0003777",
          "MEDGEN:82670",
          "MESH:C562485",
          "OMIM:261900",
          "Orphanet:2889",
          "SCTID:17170005",
          "UMLS:C0263491",
          "icd11.foundation:813238041"
        ],
        "synonyms": [
          "pili torti",
          "pili torti (disease)",
          "twisted hair",
          "coarse, dry, lusterless hair which breaks off easily",
          "pili torti, Ronchese type",
          "pili torti, early-onset"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ],
        "definition": "Pili torti is a hair shaft abnormality characterized by flat hair that is twisted at irregular intervals. Hair is normal at birth but progressively stops growing long and becomes fragile. Pili torti can be isolated or occur in association with syndromes such as Menkes disease or Bazex syndrome."
      },
      "child_count": 0,
      "reference_id": "MONDO:0009870"
    },
    {
      "id": 19002,
      "label": "pili bifurcati",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        19134
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0018703",
          "MEDGEN:1812698",
          "Orphanet:720",
          "SCTID:717360009",
          "UMLS:C5574653",
          "icd11.foundation:674923489"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ],
        "definition": "Pili bifurcati is an uncommon transitory hair shaft dysplasia characterized by segmental duplication of the hair shaft: a ramification generates two parallel branches which fuse to form a single shaft again. Each branch is covered by its own cuticle."
      },
      "child_count": 0,
      "reference_id": "MONDO:0019120"
    },
    {
      "id": 19171,
      "label": "pili gemini",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        19134
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0019026",
          "ICD9:704.8",
          "MEDGEN:42460",
          "MESH:C537188",
          "Orphanet:79492",
          "SCTID:42829009",
          "UMLS:C0019571"
        ],
        "synonyms": [
          "pili multigemini"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ],
        "definition": "Pili gemini defines a situation where the papilla's tip of a hair follicle splits during the anagen phase and consequently grows two hair shafts emerging through a single pilary canal. A papilla tip that divides in several tips will produce several hair shafts, a situation named pili multigemini. Pili gemini or multigemini can occur in each type of hair."
      },
      "child_count": 0,
      "reference_id": "MONDO:0019330"
    }
  ],
  "roots": [
    {
      "id": 4924,
      "label": "disorder of pilosebaceous unit"
    },
    {
      "id": 21436,
      "label": "skin appendage disorder"
    }
  ]
}