{
  "id": 19142,
  "label": "skin vascular disease",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0019293",
  "properties": {
    "xrefs": [
      "DOID:9540",
      "ICD9:709.1",
      "MEDGEN:102473",
      "MESH:D017445",
      "MedDRA:10062171",
      "NCIT:C35254",
      "Orphanet:79379",
      "SCTID:11263005",
      "UMLS:C0162819"
    ],
    "synonyms": [
      "skin vascular disorder",
      "superficial vasculature disease",
      "vascular disease of the skin",
      "vascular skin disease",
      "vasculature skin disease",
      "disorder of blood vessels affecting skin",
      "vascular disorder of skin",
      "vascular disorders of skin"
    ],
    "categories": [
      {
        "ref": "MONDO:0002051",
        "name": "integumentary system disorder"
      },
      {
        "ref": "MONDO:0004995",
        "name": "cardiovascular disorder"
      }
    ],
    "definition": "A disease that involves the superficial vasculature."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 20,
  "parents": [
    {
      "id": 6820,
      "label": "skin disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4198
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:37",
          "EFO:0000701",
          "ICD9:702",
          "ICD9:702.8",
          "ICD9:709.8",
          "MEDGEN:20777",
          "MESH:D012871",
          "NANDO:2100281",
          "NCIT:C3371",
          "SCTID:95320005",
          "UMLS:C0037274"
        ],
        "synonyms": [
          "cutaneous disorder",
          "disease of zone of skin",
          "disease or disorder of zone of skin",
          "disorder of skin",
          "disorder of zone of skin",
          "skin diseases and manifestations",
          "skin disorder",
          "zone of skin disease",
          "zone of skin disease or disorder",
          "dermatosis",
          "genodermatosis"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ],
        "definition": "Any deviation from the normal structure or function of the skin or subcutaneous tissue that is manifested by a characteristic set of symptoms and signs."
      },
      "child_count": 72,
      "reference_id": "MONDO:0005093"
    },
    {
      "id": 7065,
      "label": "vascular disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6736
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:178",
          "EFO:0004264",
          "ICD10CM:I00-I99",
          "ICD10CM:I70-I79",
          "ICD9:442.9",
          "MEDGEN:22621",
          "MESH:D014652",
          "NANDO:2100294",
          "NCIT:C35117",
          "SCTID:27550009",
          "UMLS:C0042373"
        ],
        "synonyms": [
          "disease of vasculature",
          "disease or disorder of vasculature",
          "disorder of vasculature",
          "vascular disorder",
          "vasculature disease",
          "vasculature disease or disorder",
          "vasculopathy"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "A general term used to describe any disease affecting blood vessels]. It includes vascular abnormalities caused by degenerative, metabolic and inflammatory conditions, embolic diseases, coagulative disorders, and functional disorders such as posteri or reversible encephalopathy syndrome."
      },
      "child_count": 60,
      "reference_id": "MONDO:0005385"
    }
  ],
  "children": [
    {
      "id": 8597,
      "label": "Behcet disease",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4370,
        19142
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:13241",
          "EFO:0003780",
          "GARD:0000848",
          "ICD9:136.1",
          "MEDGEN:2568",
          "MESH:D001528",
          "MedDRA:10004213",
          "NANDO:1200284",
          "NANDO:2200422",
          "NCIT:C34416",
          "OMIM:109650",
          "Orphanet:117",
          "SCTID:310701003",
          "UMLS:C0004943",
          "icd11.foundation:1668927157"
        ],
        "synonyms": [
          "Bechet syndrome",
          "Behcet disease",
          "Behcet syndrome",
          "Behcet's syndrome",
          "Behçet disease",
          "Behçet syndrome",
          "Behçet's syndrome",
          "Behçet-Adamantiades syndrome",
          "Morbus Behçet's syndrome",
          "silk road disease",
          "BD",
          "Behcet's disease",
          "Behçet's disease",
          "Behçet’s disease"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "A chronic, relapsing, multisystemic vasculitis characterized by mucocutaneous lesions, as well as articular, vascular, ocular and central nervous system manifestations."
      },
      "child_count": 0,
      "reference_id": "MONDO:0007191"
    },
    {
      "id": 8608,
      "label": "blue rubber bleb nevus",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        16218,
        19142,
        23867
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0005940",
          "MEDGEN:83401",
          "MESH:C536240",
          "NANDO:2201027",
          "NCIT:C4486",
          "NORD:865",
          "OMIM:112200",
          "Orphanet:1059",
          "SCTID:254784002",
          "UMLS:C0346072"
        ],
        "synonyms": [
          "BRBN",
          "BRBNS",
          "Blue Rubber Bleb Nevus syndrome",
          "bean syndrome",
          "blue rubber bleb nevus",
          "blue rubber bleb nevus syndrome"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "Blue rubber bleb nevus (BRBNS) is a rare vascular malformation disorder with cutaneous and visceral lesions frequently associated with serious, potentially fatal bleeding and anemia."
      },
      "child_count": 0,
      "reference_id": "MONDO:0007203"
    },
    {
      "id": 9412,
      "label": "familial multiple nevi flammei",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        16809,
        19142,
        20710,
        23867
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0111529",
          "GARD:0003986",
          "MEDGEN:419699",
          "MedDRA:10067193",
          "NCIT:C3840",
          "OMIM:163000",
          "Orphanet:624",
          "SCTID:416377005",
          "UMLS:C2931029"
        ],
        "synonyms": [
          "Nevus flammeus",
          "Salmon patch Nevus",
          "capillary malformations, congenital, 1, somatic, mosaic",
          "familial multiple port-wine stains",
          "port wine Nevus",
          "port wine birthmark",
          "port wine stain",
          "port wine stain of skin",
          "port wine stain of the skin",
          "port wine type hemangioma",
          "port-wine stain of skin",
          "CMC",
          "capillary malformations",
          "capillary malformations, congenital",
          "nevi flammei, familial multiple",
          "port-wine stain",
          "port-wine stain familial multiple"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "A congenital vascular malformation in the skin (birthmark) characterized by the presence of dilated capillaries. The affected area of the skin is flat and reddish-purplish in color."
      },
      "child_count": 0,
      "reference_id": "MONDO:0008094"
    },
    {
      "id": 9729,
      "label": "Sneddon syndrome",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        2933,
        19142,
        23867
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:13096",
          "EFO:1001186",
          "GARD:0007664",
          "MEDGEN:76449",
          "MESH:D018860",
          "MedDRA:10053841",
          "NORD:1726",
          "OMIM:182410",
          "Orphanet:820",
          "SCTID:238776001",
          "UMLS:C0282492",
          "icd11.foundation:1474816492"
        ],
        "synonyms": [
          "Ehrmann-Sneddon syndrome",
          "Sneddon syndrome",
          "livedo racemosa-cerebrovascular accident syndrome",
          "livedo reticularis-cerebrovascular accident syndrome",
          "Sneddon's syndrome",
          "cerebro-vascular lesions and livedo reticularis",
          "livedo racemosa and cerebrovascular accidents"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "Sneddon's syndrome (SS) is a rare non-inflammatory thrombotic vasculopathy characterized by the combination of cerebrovascular disease with livedo racemosa."
      },
      "child_count": 0,
      "reference_id": "MONDO:0008436"
    },
    {
      "id": 9824,
      "label": "generalized essential telangiectasia",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        19142
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0021087",
          "MEDGEN:140803",
          "OMIM:187260",
          "Orphanet:280774",
          "SCTID:238763007",
          "UMLS:C0406502",
          "icd11.foundation:236046211"
        ],
        "synonyms": [
          "GET",
          "Hbt",
          "telangiectasia, generalised essential",
          "telangiectasia, generalized essential",
          "telangiectasia, hereditary benign"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0008534"
    },
    {
      "id": 10306,
      "label": "cutis marmorata telangiectatica congenita",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        16809,
        19142
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0006228",
          "HP:0025107",
          "ICD9:757.8",
          "MEDGEN:83381",
          "MESH:C536226",
          "OMIM:219250",
          "Orphanet:1556",
          "SCTID:254778000",
          "UMLS:C0345419",
          "icd11.foundation:1359154853"
        ],
        "synonyms": [
          "CMTC",
          "cutis marmorata telangiectatica congenita",
          "cutis marmorata telangiectatica congenita (disease)",
          "Van Lohuizen syndrome",
          "hereditary cutis marmorata telangiectatica congenita"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "Cutis marmorata telangiectatica congenita (CMTC) is a congenital localized or generalized vascular anomaly characterized by a persistent cutis marmorata pattern with a marbled bluish to deep purple appearance, spider nevus-like telangiectasia, phlebectasia and, occasionally, ulceration and atrophy of the affected skin."
      },
      "child_count": 0,
      "reference_id": "MONDO:0009055"
    },
    {
      "id": 11639,
      "label": "angioedema",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7148,
        19142
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "CSP:2716-7007",
          "DOID:1558",
          "EFO:0005532",
          "HP:0100665",
          "ICD9:995.1",
          "MEDGEN:1543",
          "MESH:D000799",
          "SCTID:400075008",
          "UMLS:C0002994"
        ],
        "synonyms": [
          "Edemas, angioneurotic",
          "Quincke edema",
          "Quincke oedema",
          "Quincke's edema",
          "Quincke's oedema",
          "Quinckes edema",
          "Quinckes oedema",
          "Urticarias, giant",
          "angioedemas",
          "angioneurotic Edemas",
          "edema, Quincke's",
          "edema, angioneurotic",
          "giant Urticarias",
          "giant urticaria",
          "urticaria, giant",
          "angioneurotic edema",
          "angioneurotic oedema"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "Swelling involving the deep dermis, subcutaneous, or submucosal tissues, representing localized edema. Angioedema often occurs in the face, lips, tongue, and larynx."
      },
      "child_count": 6,
      "reference_id": "MONDO:0010481"
    },
    {
      "id": 12329,
      "label": "malignant atrophic papulosis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        19142
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0006249",
          "ICD9:447.8",
          "MEDGEN:113138",
          "MESH:D054853",
          "MedDRA:10064281",
          "NCIT:C84835",
          "NORD:1036",
          "OMIM:602248",
          "Orphanet:679",
          "SCTID:400171002",
          "UMLS:C0221011",
          "icd11.foundation:792094526"
        ],
        "synonyms": [
          "Degos Disease",
          "Degos disease",
          "Kohlmeier-Degos disease",
          "Kohlmeier-Degos-Delort-Tricort syndrome",
          "Köhlmeier-Degos disease",
          "Köhlmeier-Degos-Delort-Tricort syndrome",
          "malignant atrophic papulosis",
          "papulosis atrophican maligna",
          "Degos syndrome",
          "Degos's malignant atrophic papulosis",
          "atrophic papulosis, malignant",
          "papulosis, malignant atrophic"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "Malignant atrophic papulosis (MAP) is a rare, chronic, thrombo-obliterative vasculopathy characterized by papular skin lesions with central porcelain-white atrophy and a surrounding teleangiectatic rim. Systemic lesions may affect the gastrointestinal tract and the central nervous system (CNS) and are potentially lethal."
      },
      "child_count": 0,
      "reference_id": "MONDO:0011208"
    },
    {
      "id": 14822,
      "label": "familial cutaneous telangiectasia and oropharyngeal predisposition cancer syndrome",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        16218,
        19142,
        23867
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0017413",
          "MEDGEN:482833",
          "OMIM:614564",
          "Orphanet:313846",
          "UMLS:C3281203"
        ],
        "synonyms": [
          "familial cutaneous telangiectasia and oropharyngeal predisposition cancer syndrome",
          "FCTCS",
          "cutaneous telangiectasia and cancer syndrome, familial",
          "familial cutaneous telangiectasia and oropharyngeal cancer predisposition syndrome",
          "telangiectasia, cutaneous, and cancer syndrome, familial"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0013806"
    },
    {
      "id": 14824,
      "label": "Maffucci syndrome",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4599,
        16218,
        19142,
        19480,
        19507,
        21247,
        21452,
        23867
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0060221",
          "GARD:0006958",
          "MEDGEN:7437",
          "NCIT:C3213",
          "NORD:1393",
          "OMIM:614569",
          "Orphanet:163634",
          "SCTID:46041001",
          "UMLS:C0024454",
          "icd11.foundation:548780091"
        ],
        "synonyms": [
          "Chondroplasia angiomatosis",
          "Dyschondroplasia and cavernous hemangioma",
          "Maffucci syndrome",
          "Maffucci type enchondromatosis",
          "Maffucci's anomalad",
          "chondrodysplasia with hemangioma",
          "enchondromatosis with hemangiomata",
          "hemangiomata with Dyschondroplasia",
          "Dyschondrodysplasia with hemangiomas",
          "Kast syndrome",
          "enchondromatosis with multiple cavernous hemangiomas",
          "hemangiomatosis Chondrodystrophica",
          "multiple Angiomas and Endochondromas",
          "multiple enchondromatosis, Maffucci type"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "Maffucci syndrome is a very rare genetic bone and skin disorder characterized by multiple enchondromas, leading to bone deformities, combined with multiple dark, irregularly shaped hemangiomas or less commonly lymphangiomas."
      },
      "child_count": 0,
      "reference_id": "MONDO:0013808"
    },
    {
      "id": 16866,
      "label": "Bockenheimer syndrome",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        19142
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0013063",
          "MEDGEN:1843091",
          "Orphanet:217008",
          "UMLS:C5679814",
          "icd11.foundation:1659229633"
        ],
        "synonyms": [
          "genuine diffuse phlebectasia"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0016311"
    },
    {
      "id": 17556,
      "label": "calciphylaxis cutis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        17555,
        19142
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0021070",
          "MEDGEN:900547",
          "Orphanet:280065",
          "SCTID:717043006",
          "UMLS:C4274083"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "Calciphylaxis cutis is a life-threatening syndrome characterized by progressive and painful skin ulcerations associated with media calcification of medium-size and small cutaneous arterial vessels. It affects mainly patients on dialysis or after renal transplantation."
      },
      "child_count": 0,
      "reference_id": "MONDO:0017216"
    },
    {
      "id": 17578,
      "label": "cutaneous collagenous vasculopathy",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        19142
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0012428",
          "MEDGEN:930992",
          "Orphanet:280779",
          "SCTID:718634003",
          "UMLS:C4305323",
          "icd11.foundation:878108553"
        ],
        "synonyms": [
          "CCV",
          "cutaneus colagenous vasculopathy"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "Cutaneous collagenous vasculopathy (CCV) is a primary microangiopathy confined to the skin, characterized by multiple and widespread telangiectasias."
      },
      "child_count": 0,
      "reference_id": "MONDO:0017242"
    },
    {
      "id": 18820,
      "label": "Wyburn-Mason syndrome",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5091,
        16257,
        19142,
        20682,
        23107,
        23165
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0007900",
          "MEDGEN:120534",
          "MESH:C536752",
          "MedDRA:10048661",
          "NORD:1863",
          "Orphanet:53719",
          "SCTID:6729006",
          "UMLS:C0265321"
        ],
        "synonyms": [
          "CAMS2",
          "Cerebrofacial arteriovenous metameric syndrome type 2",
          "bonnet-Dechaume-Blanc syndrome",
          "Wyburn Mason syndrome",
          "Wyburn Mason's syndrome",
          "arteriovenous aneurysm of mid-brain and retina, facial nevi and mental changes",
          "bonnet-Decaume-Blanc syndrome"
        ],
        "categories": [
          {
            "ref": "MONDO:0002022",
            "name": "disorder of orbital region"
          },
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0024458",
            "name": "disorder of visual system"
          }
        ],
        "definition": "Wyburn-Mason syndrome or Bonnet-Dechaume-Blanc syndrome is characterized by the association of arteriovenous malformations of the maxilla, retina, optic nerve, thalamus, hypothalamus and cerebral cortex."
      },
      "child_count": 0,
      "reference_id": "MONDO:0018892"
    },
    {
      "id": 18821,
      "label": "Cobb syndrome",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        3493,
        5091,
        16218,
        19142,
        23867
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0011892",
          "ICD9:239.2",
          "MEDGEN:91079",
          "MedDRA:10068841",
          "NCIT:C4485",
          "Orphanet:53721",
          "SCTID:254774003",
          "UMLS:C0346068",
          "icd11.foundation:1451924695"
        ],
        "synonyms": [
          "Cobb's syndrome",
          "SAMS 1-31",
          "cutaneomeningospinal angiomatosis",
          "spinal arteriovenous metameric syndrome"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "Cobb syndrome is defined by the association of vascular cutaneous (venous or arteriovenous), muscular (arteriovenous), osseous (arteriovenous) and medullary (arteriovenous) lesions at the same metamere or spinal segment. This segmental distribution may involve one or many of the 31 metameres present in humans. Only 16% of the medullary lesions are multiple and have a clearly metameric distribution."
      },
      "child_count": 0,
      "reference_id": "MONDO:0018893"
    },
    {
      "id": 19364,
      "label": "chilblain lupus",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3017,
        16381,
        19142
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0060386",
          "GARD:0019130",
          "MEDGEN:1632142",
          "MedDRA:10025141",
          "Orphanet:90280",
          "UMLS:C4551515"
        ],
        "synonyms": [
          "CHLE",
          "Hutchinson lupus"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ],
        "definition": "A rare, chronic cutaneous lupus erythematosus disease characterized by red or violaceous, initially pruritic (evolving to painful) papules and plaques located on acral areas (especially dorsal aspects of fingers and toes, while the nose and ear involvement is uncommon), exacerbated by cold and damp conditions, with fissuring and ulceration occasionally observed. Coexistence of discoid lupus erythematosus lesions elsewhere on the body and occasional progression to systemic lupus erythematosus may be associated. Histological examination and direct immunofluorescence studies reveal nonspecific inflammatory lupus erythematosus changes while results of cryoglobulin and cold agglutinin studies are negative."
      },
      "child_count": 3,
      "reference_id": "MONDO:0019557"
    },
    {
      "id": 19544,
      "label": "angioma serpiginosum",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4409,
        5091,
        16809,
        19142
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4028",
          "GARD:0015021",
          "MEDGEN:75528",
          "NCIT:C3926",
          "Orphanet:95429",
          "SCTID:49465005",
          "UMLS:C0263637",
          "icd11.foundation:1724787481"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "Angioma serpiginosum (AS) is a benign congenital skin disease characterized by progressive dilation of the subepidermal skin vessels manifesting as purple punctate lesions usually appearing on the lower limbs and buttocks and following the lines of Blaschko."
      },
      "child_count": 8,
      "reference_id": "MONDO:0019803"
    },
    {
      "id": 21299,
      "label": "pityriasis lichenoides",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        8030,
        8068,
        19142
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0010265",
          "MEDGEN:102482",
          "MESH:D017514",
          "NCIT:C85013",
          "SCTID:200983001",
          "UMLS:C0162853",
          "icd11.foundation:266281219"
        ],
        "synonyms": [
          "Pityriasis Lichenoides",
          "pityriasis lichenoides",
          "acute Pityriasis Lichenoides",
          "chronic Pityriasis Lichenoides",
          "Pityriasis Lichenoides chronica",
          "Pityriasis Lichenoides et Varioliformis Acuta",
          "Pityriasis Lichenoides, acute",
          "Pityriasis Lichenoides, chronic"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "A rare cutaneous disorder of unknown etiology that can present either as an acute condition, with multiple papular lesions which become vesicular and necrotic (pityriasis lichenoides et varioliformis acuta) or chronic, with small, scaling papules (pityriasis lichenoides chronica)."
      },
      "child_count": 3,
      "reference_id": "MONDO:0024249"
    },
    {
      "id": 23276,
      "label": "livedo reticularis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6988,
        19142
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0025876",
          "MEDGEN:43223",
          "MESH:D054068",
          "SCTID:238772004",
          "UMLS:C0085642"
        ],
        "synonyms": [
          "livedo reticularis",
          "livedo racemosa"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "A condition characterized by a reticular or fishnet pattern on the skin of lower extremities and other parts of the body. This red and blue pattern is due to deoxygenated blood in unstable dermal blood vessels. The condition is intensified by cold exposure and relieved by rewarming."
      },
      "child_count": 0,
      "reference_id": "MONDO:0044037"
    },
    {
      "id": 25825,
      "label": "atrophic papulosis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        19142
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0026934",
          "Orphanet:656071"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ]
      },
      "child_count": 1,
      "reference_id": "MONDO:0958110"
    }
  ],
  "roots": [
    {
      "id": 6820,
      "label": "skin disorder"
    },
    {
      "id": 7065,
      "label": "vascular disorder"
    }
  ]
}