{
  "id": 19177,
  "label": "autoimmune bullous skin disease",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0019337",
  "properties": {
    "xrefs": [
      "DOID:8502",
      "EFO:0008598",
      "GARD:0019028",
      "ICD9:694.8",
      "ICD9:694.9",
      "MEDGEN:1842418",
      "Orphanet:79669",
      "SCTID:7231009",
      "UMLS:C5681494"
    ],
    "synonyms": [
      "bullous skin disease",
      "bullous dermatosis"
    ],
    "categories": [
      {
        "ref": "MONDO:0002051",
        "name": "integumentary system disorder"
      },
      {
        "ref": "MONDO:0005046",
        "name": "immune system disorder"
      }
    ],
    "definition": "An autoimmune disease characterized by blisters on the skin."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 11,
  "parents": [
    {
      "id": 4496,
      "label": "dermatitis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6820,
        20399
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2723",
          "ICD9:692.9",
          "MEDGEN:849741",
          "MESH:D003872",
          "NCIT:C2983",
          "SCTID:43116000",
          "UMLS:C3875321"
        ],
        "synonyms": [
          "inflammation of skin",
          "inflammation of the skin",
          "inflammation of zone of skin",
          "inflammatory skin disease",
          "skin inflammation",
          "zone of skin inflammation"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ],
        "definition": "An inflammatory process affecting the skin. Signs include red rash, itching, and blister formation. Representative examples are contact dermatitis, atopic dermatitis, and seborrheic dermatitis."
      },
      "child_count": 66,
      "reference_id": "MONDO:0002406"
    },
    {
      "id": 8092,
      "label": "vesiculobullous skin disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6820
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2731",
          "EFO:1000774",
          "MEDGEN:20778",
          "MESH:D012872",
          "UMLS:C0037275"
        ],
        "synonyms": [
          "vesiculobullous skin disease",
          "Sneddon Wilkinson disease",
          "Sneddon-Wilkinson disease",
          "skin diseases, vesicular",
          "subcorneal pustular dermatoses",
          "subcorneal pustular dermatosis",
          "bullous dermatoses",
          "bullous skin disease",
          "bullous skin diseases",
          "dermatoses, bullous",
          "dermatoses, subcorneal pustular",
          "dermatoses, vesiculobullous",
          "dermatosis, subcorneal pustular",
          "pustular dermatoses, subcorneal",
          "pustular dermatosis, subcorneal",
          "skin disease, bullous",
          "skin disease, vesicular",
          "skin disease, vesiculobullous",
          "skin diseases, bullous",
          "vesicular skin disease",
          "vesicular skin diseases",
          "vesiculobullous dermatoses",
          "vesiculobullous skin diseases"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ],
        "definition": "Skin diseases characterized by local or general distributions of blisters. They are classified according to the site and mode of blister formation. Lesions can appear spontaneously or be precipitated by infection, trauma, or sunlight. Etiologies include immunologic and genetic factors. (From Scientific American Medicine, 1990)"
      },
      "child_count": 8,
      "reference_id": "MONDO:0006617"
    },
    {
      "id": 8586,
      "label": "autoimmune disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6778
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:417",
          "EFO:0005809",
          "ICD9:279.4",
          "ICD9:279.49",
          "ICD9:720",
          "MEDGEN:2135",
          "MESH:D001327",
          "NCIT:C2889",
          "OBI:1110054",
          "OMIM:109100",
          "SCTID:85828009",
          "UMLS:C0004364"
        ],
        "synonyms": [
          "autoimmune disease",
          "autoimmune disease or disorder",
          "autoimmune disorder",
          "disease, autoimmune",
          "autoimmune hypersensitivity disease",
          "hypersensitivity reaction type II disease"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ],
        "definition": "A disorder resulting from loss of function or tissue destruction of an organ or multiple organs, arising from humoral or cellular immune responses of the individual to their own tissue constituents. It may be systemic (e.g., systemic lupus erythematosus), or organ specific, (e.g., thyroiditis)."
      },
      "child_count": 47,
      "reference_id": "MONDO:0007179"
    }
  ],
  "children": [
    {
      "id": 8070,
      "label": "pemphigus",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        19177
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:9182",
          "EFO:1000749",
          "GARD:0007352",
          "ICD10CM:L10",
          "ICD10WHO:L10",
          "ICD9:694.4",
          "MEDGEN:45369",
          "MESH:D010392",
          "NANDO:1200228",
          "NCIT:C34909",
          "SCTID:65172003",
          "UMLS:C0030807",
          "Wikipedia:Pemphigus",
          "icd11.foundation:191659986"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ],
        "definition": "Pemphigus is a group of rare autoimmune diseases that cause blistering of the skin and mucous membranes (mouth, nose, throat, eyes, and genitals).This conditioncan occur at any age, but often strikes people in middle or older age. Studies have shown that some populations may be at greater risk for certain types of pemphigus. For instance, people of Jewish descent and those from India, Southeast Europe, and the Middle East are at greater risk for pemphigus vulargis, while pemphigus foliaceus is more common in North America, Turkey, and South America. Pemphigus is a chronic disease which is best controlled by early diagnosis and treatment.Treatment includes steroids to reduce inflammation,drugs that suppress the immune system responseand antibiotics to treat associated infections. There are four main types of pemphigus: Pemphigus vulgaris Pemphigus foliaceus IgA pemphigus Paraneoplastic pemphigus"
      },
      "child_count": 6,
      "reference_id": "MONDO:0006594"
    },
    {
      "id": 8089,
      "label": "subcorneal pustular dermatosis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        19177
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:8508",
          "EFO:1000771",
          "GARD:0013606",
          "ICD10CM:L13.1",
          "ICD9:694.1",
          "MEDGEN:108687",
          "MedDRA:10042342",
          "Orphanet:48377",
          "SCTID:25147002",
          "UMLS:C0600336",
          "icd11.foundation:1952122675"
        ],
        "synonyms": [
          "Sneddon-Wilkinson disease",
          "pustulosis subcornealis",
          "subcorneal pustular dermatitis",
          "subcorneal pustular dermatosis"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ],
        "definition": "A rare, benign, chronic disease characterized by sterile pustular eruption, typically involving the flexural sites of the trunk and proximal extremities."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006614"
    },
    {
      "id": 16408,
      "label": "dermatitis herpetiformis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        19177
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:8505",
          "EFO:1000684",
          "GARD:0010075",
          "ICD10CM:L13.0",
          "ICD9:694.0",
          "MEDGEN:8327",
          "MESH:D003874",
          "MedDRA:10012468",
          "NCIT:C26742",
          "Orphanet:1656",
          "SCTID:111196000",
          "UMLS:C0011608",
          "Wikipedia:Dermatitis_herpetiformis",
          "icd11.foundation:286313127"
        ],
        "synonyms": [
          "Duhring's disease",
          "Durhing-Brocq disease",
          "dermatitis herpetiformis"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ],
        "definition": "Dermatitis herpetiformis (DH) is a chronic autoimmune subepidermal bullous disease characterized by grouped pruritic lesions such as papules, urticarial plaques, erythema, and herpetiform vesiculae, with a predominantly symmetrical distribution on extensor surfaces of the elbows (90%), knees (30%), shoulders, buttocks, sacral region, and face of children and adults. Erosions, excoriations and hyperpigmentation usually follow. DH may also appear as a consequence of gluten intolerance."
      },
      "child_count": 2,
      "reference_id": "MONDO:0015614"
    },
    {
      "id": 18679,
      "label": "anti-p200 pemphigoid",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        19177
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0021892",
          "MEDGEN:1802806",
          "Orphanet:454710",
          "UMLS:C5681099"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0018688"
    },
    {
      "id": 18714,
      "label": "mucous membrane pemphigoid",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        19177
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:11656",
          "EFO:1000680",
          "GARD:0005913",
          "ICD10CM:L12.1",
          "ICD9:694.6",
          "ICD9:694.61",
          "MEDGEN:10619",
          "MedDRA:10057052",
          "NANDO:1200634",
          "NCIT:C34907",
          "Orphanet:46486",
          "SCTID:34250006",
          "SCTID:76092003",
          "UMLS:C0030804",
          "icd11.foundation:1456138933"
        ],
        "synonyms": [
          "Mucosynechial pemphigoid",
          "benign mucous Membrane pemphigoid",
          "cicatricial pemphigoid",
          "mucosal pemphigoid",
          "benign mucosal pemphigoid",
          "benign mucous membrane pemphigoid",
          "benign mucous membrane pemphigoid with ocular involvement",
          "cicatricial pemphigoid with ocular involvement",
          "ocular pemphigoid",
          "ocular pemphigus"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ],
        "definition": "Mucous membrane pemphigoid is a bullous dermatosis characterized clinically by blistering of the mucous membranes followed by scarring, and immunologically by IgG, IgA and/or C3 deposits on the epidermal basement membrane."
      },
      "child_count": 1,
      "reference_id": "MONDO:0018746"
    },
    {
      "id": 18715,
      "label": "acquired epidermolysis bullosa",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        8025,
        19177
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4313",
          "EFO:1000691",
          "GARD:0006360",
          "ICD10CM:L12.3",
          "ICD9:695.19",
          "MEDGEN:37178",
          "MESH:D016107",
          "MedDRA:10056508",
          "NANDO:1200635",
          "NCIT:C84690",
          "Orphanet:46487",
          "SCTID:2772003",
          "UMLS:C0079293",
          "icd11.foundation:2034586329"
        ],
        "synonyms": [
          "EBA",
          "acquired epidermolysis bullosa",
          "epidermolysis bullosa Aquisita",
          "epidermolysis bullosa acquisita",
          "EB acquisita"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ],
        "definition": "Epidermolysis bullosa acquisita (EBA) is a subepidermal bullous dermatosis of autoimmune origin that was named as a result of its resemblance to hereditary forms of epidermolysis bullosa (HEB), most notably dystrophic HEB."
      },
      "child_count": 0,
      "reference_id": "MONDO:0018747"
    },
    {
      "id": 18716,
      "label": "linear IgA Dermatosis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        19177
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:0009313",
          "GARD:0018834",
          "MEDGEN:473106",
          "MESH:D062027",
          "MedDRA:10024515",
          "Orphanet:46488",
          "SCTID:95330001",
          "UMLS:C0406650",
          "icd11.foundation:1802341051"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ],
        "definition": "Autoimmune disease characterized by subepidermal blisters and linear deposition of autoantibodies at the dermoepidermal junction. The accumulated autoantibodies are of immunoglobulin A and occasionally immunoglobulin G classes against epidermal basement membrane proteins. The dermatosis is sometimes associated with malignancies and use of certain drugs (e.g., vancomycin)."
      },
      "child_count": 0,
      "reference_id": "MONDO:0018748"
    },
    {
      "id": 18893,
      "label": "paraneoplastic pemphigus",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        19177,
        24661
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0080852",
          "EFO:0008602",
          "GARD:0018858",
          "ICD10CM:L10.81",
          "MEDGEN:798302",
          "MedDRA:10057056",
          "NANDO:1200231",
          "Orphanet:63455",
          "UMLS:C1112570",
          "icd11.foundation:104197957"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ],
        "definition": "Pemphigus is a group of chronic autoimmune skin diseases characterized by blisters formation on the outer layer of the skin and the mucous membranes. Three clinical forms have been characterized, of which paraneoplastic pemphigus is extremely rare."
      },
      "child_count": 0,
      "reference_id": "MONDO:0018974"
    },
    {
      "id": 18973,
      "label": "bullous pemphigoid",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        19177
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:8506",
          "EFO:0007187",
          "GARD:0005972",
          "ICD10CM:L12.0",
          "ICD9:694.5",
          "MEDGEN:10620",
          "MESH:D010391",
          "NANDO:1200632",
          "NANDO:1200633",
          "NCIT:C84389",
          "Orphanet:703",
          "SCTID:77090002",
          "UMLS:C0030805",
          "icd11.foundation:233308710"
        ],
        "synonyms": [
          "bullous pemphigoid",
          "Old Age pemphigus",
          "Parapemphigus",
          "benign pemphigus",
          "senile dermatitis herpetiformis"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ],
        "definition": "Bullous pemphigoid (BP) is the most common form of autoimmune bullous dermatosis."
      },
      "child_count": 0,
      "reference_id": "MONDO:0019082"
    },
    {
      "id": 22773,
      "label": "IgA pemphigus",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        19177
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0080851",
          "GARD:0022242",
          "MEDGEN:697519",
          "Orphanet:555905",
          "UMLS:C1274167"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0034127"
    },
    {
      "id": 25196,
      "label": "pemphigoid",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        19177
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0080841",
          "GARD:0026598",
          "ICD10CM:L12",
          "ICD10WHO:L12",
          "SCTID:86142006",
          "icd11.foundation:445309625"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ],
        "definition": "An autoimmune disease of skin and connective tissue that is characterized by subepidermal blistering especially in the lower abdomen, groin, and flexor surfaces of the extremities, creating tense blisters that do not break easily."
      },
      "child_count": 0,
      "reference_id": "MONDO:0850301"
    }
  ],
  "roots": [
    {
      "id": 4496,
      "label": "dermatitis"
    },
    {
      "id": 8092,
      "label": "vesiculobullous skin disease"
    },
    {
      "id": 8586,
      "label": "autoimmune disease"
    }
  ]
}