{
  "id": 19180,
  "label": "scleroderma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0019340",
  "properties": {
    "xrefs": [
      "DOID:419",
      "EFO:1001993",
      "GARD:0018705",
      "HP:0100324",
      "MEDGEN:3770",
      "MedDRA:10039710",
      "NCIT:C26746",
      "Orphanet:801",
      "UMLS:C0011644"
    ],
    "synonyms": [
      "scleroderma",
      "scleroderma (disease)"
    ],
    "categories": [
      {
        "ref": "MONDO:0003900",
        "name": "connective tissue disorder"
      },
      {
        "ref": "MONDO:0005046",
        "name": "immune system disorder"
      }
    ],
    "definition": "Scleroderma is a rare autoimmune connective tissue disorder characterized by abnormal hardening of the skin and, sometimes, other organs. It is classified into two main forms: localized scleroderma and systemic sclerosis (SSc), the latter comprising three subsets; diffuse cutaneous SSc (dcSSc), limited cutaneous SSc (lcSSc) and limited SSc (lSSc)."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 3,
  "parents": [
    {
      "id": 7203,
      "label": "rheumatic disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5762
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1575",
          "EFO:0005755",
          "ICD9:729.0",
          "MEDGEN:3157",
          "MESH:D012216",
          "NANDO:2100151",
          "NANDO:2100152",
          "NCIT:C27204",
          "SCTID:396332003",
          "UMLS:C0009326",
          "Wikipedia:Rheumatism"
        ],
        "synonyms": [
          "rheumatic disease",
          "rheumatologic disorder",
          "collagen disease",
          "collagen vascular disease",
          "connective tissue disease",
          "disease, rheumatic",
          "diseases, rheumatic",
          "enthesopathies",
          "enthesopathy",
          "inflammatory rheumatism",
          "musculoskeletal pain disorder",
          "rheumatism"
        ],
        "categories": [
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          }
        ],
        "definition": "Inflammatory and degenerative diseases of connective tissue structures, such as arthritis."
      },
      "child_count": 30,
      "reference_id": "MONDO:0005554"
    },
    {
      "id": 8586,
      "label": "autoimmune disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6778
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:417",
          "EFO:0005809",
          "ICD9:279.4",
          "ICD9:279.49",
          "ICD9:720",
          "MEDGEN:2135",
          "MESH:D001327",
          "NCIT:C2889",
          "OBI:1110054",
          "OMIM:109100",
          "SCTID:85828009",
          "UMLS:C0004364"
        ],
        "synonyms": [
          "autoimmune disease",
          "autoimmune disease or disorder",
          "autoimmune disorder",
          "disease, autoimmune",
          "autoimmune hypersensitivity disease",
          "hypersensitivity reaction type II disease"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ],
        "definition": "A disorder resulting from loss of function or tissue destruction of an organ or multiple organs, arising from humoral or cellular immune responses of the individual to their own tissue constituents. It may be systemic (e.g., systemic lupus erythematosus), or organ specific, (e.g., thyroiditis)."
      },
      "child_count": 47,
      "reference_id": "MONDO:0007179"
    }
  ],
  "children": [
    {
      "id": 6827,
      "label": "systemic sclerosis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6820,
        19180
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:418",
          "EFO:0000717",
          "GARD:0009748",
          "ICD10CM:M34",
          "ICD10WHO:M34",
          "ICD9:710.1",
          "MEDGEN:19897",
          "MESH:D012595",
          "MedDRA:10042953",
          "NANDO:1200277",
          "NANDO:2200429",
          "NCIT:C72070",
          "NORD:2007",
          "Orphanet:90291",
          "SCTID:89155008",
          "UMLS:C0036421",
          "icd11.foundation:1084365812"
        ],
        "synonyms": [
          "Scleroderma",
          "PSS (progressive systemic sclerosis)",
          "SSc",
          "SSc, diffuse sclerosis",
          "Scleroderma (& [systemic sclerosis])",
          "Scleroderma, diffuse",
          "Scleroderma, systemic",
          "Systemic Scleroderma",
          "diffuse Scleroderma",
          "diffuse sclerosis",
          "systemic Scleroderma",
          "systemic scleroderma",
          "systemic sclerosis"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ],
        "definition": "A chronic disorder, possibly autoimmune, marked by excessive production of collagen which results in hardening and thickening of body tissues. The two types of systemic scleroderma, limited cutaneous and diffuse cutaneous are classified with focus on the extent of affected skin. A relationship exists between the extent of skin area affected and degree of internal organ/system involvement. Systemic scleroderma can manifest itself in pulmonary fibrosis, Raynaud's syndrome, digestive system telangiectasias, renal hypertension and/or pulmonary hypertension."
      },
      "child_count": 12,
      "reference_id": "MONDO:0005100"
    },
    {
      "id": 18444,
      "label": "neonatal scleroderma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        18439,
        19180
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0021648",
          "MEDGEN:1652107",
          "Orphanet:398127",
          "UMLS:C4509425"
        ],
        "categories": [
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0018361"
    },
    {
      "id": 19369,
      "label": "localized scleroderma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        19180
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:8472",
          "EFO:1001361",
          "GARD:0007058",
          "ICD10CM:L94.0",
          "ICD9:701.0",
          "MEDGEN:48586",
          "MESH:D012594",
          "MedDRA:10039712",
          "NCIT:C72069",
          "Orphanet:90289",
          "SCTID:201048007",
          "UMLS:C0036420",
          "icd11.foundation:1430740369"
        ],
        "synonyms": [
          "circumscribed scleroderma",
          "localised fibrosing scleroderma",
          "localised scleroderma (disorder) [ambiguous]",
          "localized fibrosing scleroderma",
          "localized morphoea",
          "localized scleroderma",
          "localized scleroderma (disorder) [ambiguous]",
          "morphea",
          "Scleroderma, localised",
          "Scleroderma, localized"
        ],
        "categories": [
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ],
        "definition": "Localized scleroderma is the skin localized form of scleroderma characterized by fibrosis of the skin causing cutaneous plaques or strips."
      },
      "child_count": 2,
      "reference_id": "MONDO:0019562"
    }
  ],
  "roots": [
    {
      "id": 7203,
      "label": "rheumatic disorder"
    },
    {
      "id": 8586,
      "label": "autoimmune disease"
    }
  ]
}