{
  "id": 19203,
  "label": "complex regional pain syndrome",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0019369",
  "properties": {
    "xrefs": [
      "DOID:14022",
      "DOID:3223",
      "EFO:1001998",
      "GARD:0004647",
      "ICD10CM:M89.0",
      "MEDGEN:96846",
      "MESH:D020918",
      "MedDRA:10064332",
      "NORD:1652",
      "Orphanet:83452",
      "SCTID:128200000",
      "UMLS:C0458219",
      "icd11.foundation:1834504950"
    ],
    "synonyms": [
      "CRPS",
      "algoneurodystrophy",
      "reflex sympathetic dystrophy"
    ],
    "categories": [
      {
        "ref": "MONDO:0005071",
        "name": "nervous system disorder"
      }
    ],
    "definition": "A chronic pain syndrome characterized by a disproportionate spontaneous or stimulus-induced pain, accompanied by a variably mixed myriad of autonomic and motor disorders including symptoms such as swelling, allodynia, skin blood supply and trophic disturbances. CRPS most often affects one of the arms, legs, hands, or feet and usually occurs after an injury or trauma to that limb."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 2,
  "parents": [
    {
      "id": 21350,
      "label": "chronic pain syndrome",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        24453
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "ICD10CM:G89.4",
          "ICD9:338.4",
          "MEDGEN:720585",
          "SCTID:373621006",
          "UMLS:C1298685"
        ],
        "synonyms": [
          "chronic disorder involving pain",
          "chronic pain disease",
          "disorder involving pain, chronic"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Chronic form of disorder involving pain."
      },
      "child_count": 3,
      "reference_id": "MONDO:0024317"
    }
  ],
  "children": [
    {
      "id": 12546,
      "label": "complex regional pain syndrome type 1",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4370,
        19203
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1811",
          "EFO:1001147",
          "GARD:0016928",
          "ICD10CM:G90.5",
          "ICD9:337.2",
          "ICD9:337.20",
          "ICD9:337.21",
          "ICD9:337.29",
          "ICD9:733.7",
          "MEDGEN:11159",
          "MESH:D012019",
          "MedDRA:10038249",
          "MedDRA:10064334",
          "NCIT:C85042",
          "OMIM:604335",
          "Orphanet:99995",
          "SCTID:50642008",
          "UMLS:C0034931"
        ],
        "synonyms": [
          "Algodystrophy",
          "CRPS I",
          "CRPS1",
          "Complex regional pain syndrome I",
          "RND",
          "RSDS",
          "complex regional pain syndrome type 1",
          "reflex neurovascular dystrophy",
          "reflex sympathetic dystrophy",
          "reflex sympathetic dystrophy syndrome"
        ],
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Complex regional pain syndrome type 1 (CRPS1) is a form of complex regional pain syndrome in which the pain is disproportionate to any known inciting event and is characterized by continuous pain, allodynia, or hyperalgesia as well as edema, coloration (changes in skin blood flow), or abnormal sudomotor activity in the region of pain. Onset of CRPS1 symptoms may occur within a few days to a month after an injury or trauma to the affected limb."
      },
      "child_count": 0,
      "reference_id": "MONDO:0011441"
    },
    {
      "id": 20010,
      "label": "complex regional pain syndrome type 2",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4370,
        19203
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3222",
          "EFO:1000854",
          "GARD:0019727",
          "MEDGEN:2918",
          "MESH:D002422",
          "MedDRA:10007825",
          "MedDRA:10064335",
          "NCIT:C121572",
          "Orphanet:99994",
          "SCTID:408751001",
          "UMLS:C0007462"
        ],
        "synonyms": [
          "CRPS II",
          "Complex regional pain syndrome II",
          "causalgia"
        ],
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Complex regional pain syndrome type 2 (CRPS2), or causalgia is a form of complex regional pain syndrome that develops after damage to a peripheral nerve and is characterized by spontaneous pain, allodynia and hyperalgesia, not necessarily limited to the territory of the injured nerve, as well as at some point, edema, changes in skin blood flow or sudomotor dysfunction in the pain area."
      },
      "child_count": 0,
      "reference_id": "MONDO:0020572"
    }
  ],
  "roots": [
    {
      "id": 21350,
      "label": "chronic pain syndrome"
    }
  ]
}