{
  "id": 19214,
  "label": "acute disseminated encephalomyelitis",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0019383",
  "properties": {
    "xrefs": [
      "DOID:639",
      "EFO:0007130",
      "GARD:0008639",
      "ICD9:136.9",
      "MEDGEN:4033",
      "MESH:D004673",
      "NCIT:C34578",
      "NORD:727",
      "Orphanet:83597",
      "SCTID:83942000",
      "UMLS:C0014059",
      "icd11.foundation:1390433308"
    ],
    "synonyms": [
      "ADEM",
      "acute disseminated encephalitis",
      "acute disseminated encephalomyelitis",
      "post-infectious encephalomyelitis",
      "ADE"
    ],
    "categories": [
      {
        "ref": "MONDO:0005071",
        "name": "nervous system disorder"
      }
    ],
    "definition": "Acute disseminated encephalomyelitis (ADEM) is a demyelinating disorder of the central nervous system."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 3,
  "parents": [
    {
      "id": 4626,
      "label": "demyelinating disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7208,
        20383
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3213",
          "MEDGEN:4189",
          "MESH:D003711",
          "NCIT:C34527",
          "UMLS:C0011303"
        ],
        "synonyms": [
          "demyelinating disorder"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A broad group of disorders that affect the myelin sheaths that cover the neurons. Myelin sheathes cover neuronal axons in the central and peripheral nervous system and function to increase traveling impulse speeds. Disruption of this sheath impairs neuronal transmission and can result in disorders such as multiple sclerosis and Guillain-Barre syndrome, among others."
      },
      "child_count": 16,
      "reference_id": "MONDO:0002562"
    },
    {
      "id": 19722,
      "label": "postinfectious encephalitis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        19721,
        20718
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:10993",
          "GARD:0025152",
          "ICD9:323.6",
          "MEDGEN:581376",
          "MedDRA:10057235",
          "Orphanet:98253",
          "SCTID:192727001",
          "UMLS:C0393459"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ]
      },
      "child_count": 14,
      "reference_id": "MONDO:0020068"
    }
  ],
  "children": [
    {
      "id": 12803,
      "label": "acute hemorrhagic leukoencephalitis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5275,
        19214
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:10992",
          "EFO:0007132",
          "GARD:0008629",
          "ICD9:136.9",
          "MEDGEN:4937",
          "MESH:D004684",
          "NCIT:C84535",
          "OMIM:606752",
          "SCTID:72986009",
          "UMLS:C0014077"
        ],
        "synonyms": [
          "AHL",
          "acute hemorrhagic leukoencephalitis",
          "AHLE",
          "Ahl"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Acute hemorrhagic leukoencephalitis(AHL) is a veryrareform of acute disseminated encephalomyelitis that usuallyresults indeath. It is characterized by a brief but intense attack of inflammation in the brain and spinal cord that damages the myelin -- the protective covering of the nerve fibers. It may also cause bleeding in the brain, leading to damage of the white matter. Symptoms usually come on quickly, beginning with symptoms such as fever, neck stiffness, fatigue, headache, nausea vomiting,seizures, and coma.AHL has a very poor prognosis, with rapid deterioration and death usually occurring within days to one week after onset of symptoms because of severe inflammation in the brain. Although the exact cause is unclear,AHL usually followsaviral infection, or less often, vaccination for measles, mumps, or rubella. Some researchers think that an infection or vaccination can initiate an autoimmune process in the body thus leading to AHL."
      },
      "child_count": 0,
      "reference_id": "MONDO:0011716"
    },
    {
      "id": 22888,
      "label": "acute disseminated encephalomyelitis with anti-MOG antibodies",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        19214,
        29255
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0022378",
          "ICD10CM:G04.0",
          "MEDGEN:1842363",
          "Orphanet:592894",
          "UMLS:C5680301"
        ],
        "synonyms": [
          "ADEM with anti-MOG antibodies",
          "Acute disseminated encephalomyelitis with anti-myelin oligodendrocyte glycoprotein antibodies"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0035669"
    },
    {
      "id": 22889,
      "label": "acute disseminated encephalomyelitis without anti-MOG antibodies",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        19214
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0022379",
          "ICD10CM:G04.0",
          "MEDGEN:1843027",
          "Orphanet:592900",
          "UMLS:C5680302"
        ],
        "synonyms": [
          "Acute disseminated encephalomyelitis without anti-myelin oligodendrocyte glycoprotein antibodies"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0035670"
    }
  ],
  "roots": [
    {
      "id": 4626,
      "label": "demyelinating disease"
    },
    {
      "id": 19722,
      "label": "postinfectious encephalitis"
    }
  ]
}