{
  "id": 19223,
  "label": "idiopathic malabsorption due to bile acid synthesis defects",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0019393",
  "properties": {
    "xrefs": [
      "GARD:0019046",
      "MEDGEN:900722",
      "Orphanet:84065",
      "UMLS:C4274509"
    ],
    "synonyms": [
      "idiopathic bile acid malabsorption"
    ],
    "categories": [
      {
        "ref": "MONDO:0004335",
        "name": "digestive system disorder"
      }
    ],
    "definition": "Idiopathic malabsorption due to increased acid bile synthesis is an intestinal disease of unknown etiology characterized by an overproduction of bile acids which leads to chronic watery diarrhea."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 19085,
      "label": "inborn disorder of bile acid synthesis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        19059,
        19117,
        23517
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0018949",
          "GTR:AN0923838",
          "MEDGEN:98324",
          "NANDO:2200506",
          "NORD:854",
          "Orphanet:79168",
          "UMLS:C0400973"
        ],
        "synonyms": [
          "Bile Acid Synthesis Disorders",
          "inborn bile acid biosynthetic process disorder",
          "inborn error of bile acid biosynthetic process",
          "rare inborn error of bile acid biosynthetic process",
          "disorder of bile acid synthesis",
          "inborn errors of bile acid synthesis"
        ],
        "definition": "Anomalies of bile acid synthesis are a group of sterol metabolism disorders due to enzyme deficiencies of bile acid synthesis (BAS) in infants, children and adults, with variable manifestations that include cholestasis, neurological disease, and fat malabsorption. Nine inborn errors have been described, 7 of which lead to liver cholestasis."
      },
      "child_count": 15,
      "reference_id": "MONDO:0019218"
    },
    {
      "id": 20033,
      "label": "malabsorption syndrome",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6756
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:0009554",
          "MEDGEN:44256",
          "MESH:D008286",
          "NCIT:C3214",
          "SCTID:32230006",
          "UMLS:C0024523"
        ],
        "synonyms": [
          "malabsorption",
          "malabsorption syndrome"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "A syndrome resulting from the inadequate absorption of nutrients in the small intestine. Symptoms include abdominal pain, bloating, and diarrhea."
      },
      "child_count": 9,
      "reference_id": "MONDO:0020598"
    },
    {
      "id": 24405,
      "label": "idiopathic disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        29381
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:548250",
          "UMLS:C0277553"
        ],
        "synonyms": [
          "idiopathic disorder"
        ],
        "definition": "A disease or disorder for which the cause is of uncertain or unknown."
      },
      "child_count": 79,
      "reference_id": "MONDO:0700007"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 19085,
      "label": "inborn disorder of bile acid synthesis"
    },
    {
      "id": 20033,
      "label": "malabsorption syndrome"
    },
    {
      "id": 24405,
      "label": "idiopathic disease"
    }
  ]
}