{
  "id": 19230,
  "label": "sporadic idiopathic steroid-resistant nephrotic syndrome",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0019401",
  "properties": {
    "xrefs": [
      "GARD:0025136",
      "MEDGEN:897207",
      "Orphanet:84271",
      "SCTID:717191005",
      "UMLS:C4274017"
    ],
    "synonyms": [
      "sporadic idiopathic nephrosis"
    ],
    "categories": [
      {
        "ref": "MONDO:0002118",
        "name": "urinary system disorder"
      },
      {
        "ref": "MONDO:0002254",
        "name": "syndromic disease"
      }
    ],
    "definition": "Steroid-resistant, sporadic idiopathic nephrotic syndrome, is a heterogeneous entity. Nephrotic syndrome is characterized by marked proteinuria, with reduced plasmatic levels of albumin, and potentially with edema."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 3,
  "parents": [
    {
      "id": 18314,
      "label": "idiopathic nephrotic syndrome",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7058,
        24405
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0021539",
          "MEDGEN:501252",
          "NANDO:1200719",
          "NCIT:C122796",
          "Orphanet:357502",
          "UMLS:C3496337"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          },
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          }
        ],
        "definition": "Nephrotic syndrome for which no cause has been identified."
      },
      "child_count": 10,
      "reference_id": "MONDO:0018170"
    },
    {
      "id": 23429,
      "label": "steroid-resistant nephrotic syndrome",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7058
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0027973",
          "GTR:AN0096391",
          "GTR:AN0096395",
          "GTR:AN0200342",
          "GTR:AN0255485",
          "MEDGEN:588369",
          "NCIT:C122798",
          "SCTID:236381000",
          "UMLS:C0403397"
        ],
        "synonyms": [
          "nephrotic syndrome of childhood - steroid resistant",
          "nephrotic syndrome-steroid-resistant",
          "steroid-resistant nephrotic syndrome",
          "nephrotic syndrome, idiopathic, steroid-resistant",
          "nephrotic syndrome, steroid-resistant, autosomal recessive",
          "NPHS2",
          "SRNS - steroid-resistant nephrotic syndrome",
          "steroid-unresponsive nephrotic syndrome"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          },
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          }
        ],
        "definition": "Nephrotic syndrome, occurring in the pediatric population, in which proteinuria does not normalize with administration of steroids; this condition is unresponsive to a minimum of four weeks administration of oral corticosteroids."
      },
      "child_count": 4,
      "reference_id": "MONDO:0044765"
    }
  ],
  "children": [
    {
      "id": 19445,
      "label": "sporadic idiopathic steroid-resistant nephrotic syndrome with focal segmental hyalinosis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        19230
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "Orphanet:93218"
        ],
        "synonyms": [
          "sporadic idiopathic steroid-resistant nephrotic syndrome with focal segmental glomerulosclerosis"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          },
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0019655"
    },
    {
      "id": 19446,
      "label": "sporadic idiopathic steroid-resistant nephrotic syndrome with diffuse mesangial sclerosis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        19230
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "Orphanet:93220"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          },
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0019656"
    },
    {
      "id": 19697,
      "label": "sporadic idiopathic steroid-resistant nephrotic syndrome with collapsing glomerulopathy",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        19230
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "Orphanet:97555"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          },
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0019986"
    }
  ],
  "roots": [
    {
      "id": 18314,
      "label": "idiopathic nephrotic syndrome"
    },
    {
      "id": 23429,
      "label": "steroid-resistant nephrotic syndrome"
    }
  ]
}