{
  "id": 19233,
  "label": "perineurioma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0019404",
  "properties": {
    "xrefs": [
      "DOID:4697",
      "GARD:0012698",
      "ICD9:215.9",
      "ICDO:9571/0",
      "MEDGEN:199712",
      "NCIT:C4973",
      "Orphanet:85102",
      "SCTID:404036006",
      "UMLS:C0751691",
      "icd11.foundation:456459236"
    ],
    "synonyms": [
      "perineurioma",
      "soft tissue perineurioma"
    ],
    "categories": [
      {
        "ref": "MONDO:0005071",
        "name": "nervous system disorder"
      }
    ],
    "definition": "A usually benign perineurioma not associated with a nerve, arising from the soft tissues."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 3,
  "parents": [
    {
      "id": 4613,
      "label": "nerve sheath neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3627,
        20287
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3193",
          "GARD:0023161",
          "MEDGEN:64639",
          "MESH:D018317",
          "NCIT:C4972",
          "ONCOTREE:NST",
          "UMLS:C0206727"
        ],
        "synonyms": [
          "neoplasm of nerve sheath",
          "neoplasm of the nerve sheath",
          "nerve sheath neoplasm",
          "nerve sheath tumor",
          "tumor of nerve sheath",
          "tumour of nerve sheath"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A benign or malignant neoplasm arising from the perineural cells in the sheaths surrounding the nerves. Representative examples include neurofibroma, schwannoma, and malignant peripheral nerve sheath tumor."
      },
      "child_count": 12,
      "reference_id": "MONDO:0002547"
    },
    {
      "id": 17197,
      "label": "tumor of cranial and spinal nerves",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        20456
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0012697",
          "MEDGEN:1842705",
          "Orphanet:252057",
          "UMLS:C5679636"
        ],
        "synonyms": [
          "rare tumor of cranial and spinal nerves",
          "rare tumour of cranial and spinal nerves"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ]
      },
      "child_count": 4,
      "reference_id": "MONDO:0016749"
    }
  ],
  "children": [
    {
      "id": 16007,
      "label": "extraneural perineurioma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        19233
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0019730",
          "MEDGEN:1643216",
          "NCIT:C6912",
          "Orphanet:100002",
          "SCTID:768926005",
          "UMLS:C4708595",
          "icd11.foundation:691853283"
        ],
        "synonyms": [
          "soft tissue perineurioma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Extraneural perineurioma is a rare tumor of cranial and spinal nerves arising from peripheral nerve sheet and composed exclusively or predominantly of cells showing perineurial differentiation. It presents as a well-circumscribed, rarely encapsulated mass, not associated with a recognizable nerve, most commonly arising in the dermis and subcutis of the extremities or trunk, or, rarely, in deep soft tissue or skin (e.g., in the stomach, kidney, pancreas, maxillary sinus, mandible, bronchial tree and the face). The clinical presentation depends on the localization."
      },
      "child_count": 2,
      "reference_id": "MONDO:0015031"
    },
    {
      "id": 16008,
      "label": "intraneural perineurioma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        19233
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4696",
          "GARD:0010921",
          "MEDGEN:237162",
          "NCIT:C6911",
          "Orphanet:100003",
          "SCTID:768934004",
          "UMLS:C1370658",
          "icd11.foundation:362421359"
        ],
        "synonyms": [
          "intraneural perineurioma",
          "intraneural perineurioma (WHO grade I)"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A WHO grade I perineurioma that arises within the endoneurium. It is characterized by the formation of pseudo-onion bulbs by the proliferating perineural cells."
      },
      "child_count": 0,
      "reference_id": "MONDO:0015032"
    },
    {
      "id": 17199,
      "label": "malignant perineurioma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        19233,
        20329,
        24071
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0020741",
          "ICDO:9571/3",
          "MEDGEN:220432",
          "NCIT:C66845",
          "Orphanet:252128",
          "SCTID:761958009",
          "UMLS:C1266188",
          "icd11.foundation:986576766"
        ],
        "synonyms": [
          "malignant peripheral nerve sheath tumor with perineurial differentiation",
          "malignant peripheral nerve sheath tumour with perineurial differentiation",
          "perineurial malignant peripheral nerve sheath tumor",
          "perineurial malignant peripheral nerve sheath tumour",
          "perineurioma, malignant"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A very rare malignant tumor with morphologic features similar to those of benign perineurioma of soft tissue along with hypercellularity, nuclear atypia, hyperchromasia, and a high mitotic rate."
      },
      "child_count": 0,
      "reference_id": "MONDO:0016751"
    }
  ],
  "roots": [
    {
      "id": 4613,
      "label": "nerve sheath neoplasm"
    },
    {
      "id": 17197,
      "label": "tumor of cranial and spinal nerves"
    }
  ]
}