{
  "id": 19265,
  "label": "AL amyloidosis",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0019438",
  "properties": {
    "xrefs": [
      "DOID:0080933",
      "GARD:0005797",
      "MEDGEN:75674",
      "MESH:C531616",
      "MedDRA:10036673",
      "NANDO:1200211",
      "NCIT:C158963",
      "Orphanet:85443",
      "UMLS:C0268381",
      "icd11.foundation:1061366491",
      "icd11.foundation:113043090"
    ],
    "synonyms": [
      "Light-chain amyloidosis",
      "primary amyloidosis",
      "Light chain amyloidosis",
      "amyloidosis AL",
      "amyloidosis primary systemic",
      "primary AL amyloidosis",
      "primary systemic AL amyloidosis",
      "primary systemic amyloidosis",
      "systemic AL amyloidsis"
    ],
    "categories": [
      {
        "ref": "MONDO:0002081",
        "name": "musculoskeletal system disorder"
      },
      {
        "ref": "MONDO:0004995",
        "name": "cardiovascular disorder"
      },
      {
        "ref": "MONDO:0005071",
        "name": "nervous system disorder"
      }
    ],
    "definition": "AL Amyloidosis is a plasma cell disorder characterized by the aggregation and deposition of insoluble amyloid fibrils derived from misfolding of monoclonal immunoglobulin light chains usually produced by a plasma cell tumor. It usually presents as primary systemic amyloidosis (PSA) with multiple organ involvement and less frequently as primary localized amyloidosis (PLA) restricted to a single organ."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 2,
  "parents": [
    {
      "id": 6799,
      "label": "nervous system disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        29379
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:863",
          "EFO:0000618",
          "ICD10CM:G00-G99",
          "ICD9:349.89",
          "ICD9:349.9",
          "MEDGEN:14336",
          "MESH:D009422",
          "NCIT:C26835",
          "SCTID:118940003",
          "UMLS:C0027765",
          "Wikipedia:Nervous_system_disease"
        ],
        "synonyms": [
          "disease of nervous system",
          "disease or disorder of nervous system",
          "disorder of nervous system",
          "nervous system disease",
          "nervous system disease or disorder",
          "nervous system disorder",
          "neurologic disease",
          "neurologic disorder",
          "neurological disease",
          "neurological disorder"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A non-neoplastic or neoplastic disorder that affects the brain, spinal cord, or peripheral nerves."
      },
      "child_count": 72,
      "reference_id": "MONDO:0005071"
    },
    {
      "id": 7996,
      "label": "acquired metabolic disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6795
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0060158",
          "EFO:1000639"
        ],
        "synonyms": [
          "acquired metabolic disease"
        ],
        "definition": "An instance of metabolic disease that is acquired during the lifetime of the individual."
      },
      "child_count": 13,
      "reference_id": "MONDO:0006504"
    },
    {
      "id": 16875,
      "label": "non-familial hypertrophic cardiomyopathy",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6777
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:1843178",
          "Orphanet:217598",
          "UMLS:C5680883"
        ],
        "synonyms": [
          "acquired hypertrophic cardiomyopathy"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "An instance of hypertrophic cardiomyopathy that is acquired during the lifetime of the individual."
      },
      "child_count": 3,
      "reference_id": "MONDO:0016330"
    },
    {
      "id": 16883,
      "label": "non-familial restrictive cardiomyopathy",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6919
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0020535",
          "MEDGEN:1843079",
          "NANDO:1200294",
          "Orphanet:217720",
          "UMLS:C5680885",
          "icd11.foundation:2097520643"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ]
      },
      "child_count": 7,
      "reference_id": "MONDO:0016345"
    },
    {
      "id": 18960,
      "label": "amyloidosis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        20409
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:9120",
          "EFO:1001875",
          "GARD:0018676",
          "HP:0011034",
          "ICD10CM:E85",
          "ICD10WHO:E85",
          "ICD9:277.3",
          "ICD9:277.30",
          "MEDGEN:272",
          "MESH:D000686",
          "MedDRA:10002022",
          "NANDO:2200138",
          "NCIT:C2868",
          "ONCOTREE:MIDDA",
          "Orphanet:69",
          "SCTID:17602002",
          "UMLS:C0002726",
          "icd11.foundation:2078467774"
        ],
        "synonyms": [
          "amyloid",
          "amyloid disease",
          "amyloidoses",
          "amyloidosis",
          "amyloidosis (disease)"
        ],
        "definition": "A disorder characterized by the localized or diffuse accumulation of amyloid protein in various anatomic sites. It may be primary, due to clonal plasma cell proliferations; secondary, due to long standing infections, chronic inflammatory disorders, or malignancies; or familial. It may affect the nerves, skin, tongue, joints, heart, liver, spleen, kidneys and adrenal glands."
      },
      "child_count": 12,
      "reference_id": "MONDO:0019065"
    }
  ],
  "children": [
    {
      "id": 18037,
      "label": "primary systemic amyloidosis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        19265
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0017431",
          "MEDGEN:129028",
          "NANDO:1200209",
          "NCIT:C8299",
          "Orphanet:314701",
          "SCTID:89449005",
          "UMLS:C0281479"
        ],
        "synonyms": [
          "systemic AL amyloidosis",
          "systemic Immunoglobulin Light chain amyloidosis",
          "systemic amyloidosis"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Primary systemic amyloidosis (PSA) is a form of AL amyloidosis caused by the aggregation and deposition of insoluble amyloid fibrils derived from misfolded monoclonal immunoglobulin light chains usually produced by a plasma cell tumor and characterized by multiple organ involvement."
      },
      "child_count": 0,
      "reference_id": "MONDO:0017816"
    },
    {
      "id": 18038,
      "label": "primary localized amyloidosis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        19265
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0021387",
          "MEDGEN:107462",
          "Orphanet:314709",
          "UMLS:C0544840"
        ],
        "synonyms": [
          "localised AL amyloidosis",
          "localized AL amyloidosis"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Primary localized amyloidosis is a form of AL amyloidosis caused by the aggregation of insoluble amyloid fibrils derived from misfolded monoclonal immunoglobulin light chains usually produced by a plasma cell tumor and characterized by localized amyloid deposition with clinical manifestations restricted to the organ involved, most frequently urinary tract (bladder), eye, respiratory tract (larynx, lungs), and skin."
      },
      "child_count": 0,
      "reference_id": "MONDO:0017817"
    }
  ],
  "roots": [
    {
      "id": 6799,
      "label": "nervous system disorder"
    },
    {
      "id": 7996,
      "label": "acquired metabolic disease"
    },
    {
      "id": 16875,
      "label": "non-familial hypertrophic cardiomyopathy"
    },
    {
      "id": 16883,
      "label": "non-familial restrictive cardiomyopathy"
    },
    {
      "id": 18960,
      "label": "amyloidosis"
    }
  ]
}